高建刚 - 山东大学 - 生命科学学院

个人简介

教育背景博士 1989.9-1992.12 山东大学、北京大学发育生物学硕士 1986.9-1989.7 山东大学胚胎学本科 1982.9-1986.7 山东大学动物学工作经历 2007.10-现在山东大学生命科学学院教授, 博导，泰山学者 1999.3-2007.10 美国St Jude儿童研究医院 Lab Supervisor 1997.3-1999.2 澳大利亚昆士兰大学 Research Officer(A level) 1995.2-1997.2 中科院北京发育生物学研究所副研究员 1993.1-1995.1 中科院上海细胞生物学研究所博士后

研究领域

1. 胚胎干细胞，基因打靶和转基因动物相关的研究 2. 人类疾病动物模型的制作及发育相关基因功能的研究

近期论文

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1. Jiangang Gao, Kyeongmi Cheon , Steven Nusinowitz, Daiger, Debora B. Farber, John R. Heckenlively, Eric A. Pierce, Lori S. Sullivan and Jian Zuo. Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene. PNAS 99: 5698-5703 (2002). 2. M.Charles Liberman#, Jiangang Gao#, David Z.Z. He, Xudong Wu, Shuping Jia and Jian Zuo. Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature 419: 300-304 (2002). #Equal first authors 3. Jiangang Gao, Stéphane F. Maison, Xudong Wu , Kirko Hirose, Ildar Bayazitov, Yong Tian, Guy Mittleman, Douglas B Matthews , Stanislav S. Zakharenko, M. Charles Liberman and Jian Zuo. Orphan Glutamate Receptor 1 Subunit Required for High-Frequency Hearing. Mol Cell Biol. 27(12): 4500-12 (2007). 4. Jiangang Gao, Xiang Wang, Xudong Wu, Keiji Matsuda, Manish Patel, Jing Zheng, MaryAnn Cheatham, David Z.Z He, Peter Dallos and Jian Zuo. Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier. PNAS 104 (30): 12542-47 (2007). 5. Chen Sun, Jing Zhao, Yecheng Jin, Congzhe Hou, Wen Zong, Tingting Lu, Huashun Li and Jiangang Gao*, PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice. NeuroReport 25(3):177-83（2014）. 6. Congzhe Hou， Lingcui Ding， Yecheng Jin， Chen Sun， Zhenzu Li， Xiaoyang Sun， Huashun Li* and Jiangang Gao*, Abnormal Cerebellar Development and Purkinje Cell Defects in Lgl1-Pax2 Conditional Knockout Mice. Developmental Biology 395(1):167-81 (2014). 7. Wen Zong, Shuoyang Liu, Xiaotong Wang, Jian Zhang, Tingting Zhang, Ziyi Liu, Dongdong Wang, Aizhen Zhang, Minsheng Zhu*, Jiangang Gao*. Trio gene is required for mouse learning ability. B r a i n Re s e a r c h 1 6 0 8 : 8 2 – 9 0 ( 2 0 1 5 ). 8. Jian Zhang, Rui Yang, Ziyi Liu, Congzhe Hou, Wen Zong, Aizhen Zhang, Xiaoyang Sun and Jiangang Gao*. Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice. Human Molecular Genetics 24 (21):6174-6185(2015). 9. Jian Zhang, Ziyi Liu, Aoshuang Chang, Jie Fang, Yuqin Men, Yong Tian, Xiaomei Ouyange, Denise Yane, Aizhen Zhang, Xiaoyang Sun, Jie Tang, Xuezhong Liu* , Jian Zuo*, Jiangang Gao*，Abnormal mRNA splicing but normal auditory brainstem response (ABR) in mice with the prestin (SLC26A5) IVS2-2A > G mutation. Mutation Research 790 (2016) 1–7. 10. Yecheng Jin, Naixia Ren, Shiwei Li, Xiaoyang Sun, Yuqin Men, Zhigang Xu,Jian Zhang, Yue Xie, Ming Xia* and Jiangang Gao*, Deletion of Brg1 causes abnormal hair cell planer polarity, hair cell anchorage, and scar formation in mouse cochlea. Scientific Reports 6:27124 (2016 ).| DOI: 10.1038/srep27124.