研究领域

Asymmetrisynthesi ;β-Homoaminacid ;Chemicacarcinogenesi ;Greechemistr ;Novelipopeptides

My laboratory is engaged in two research areas: 1) the preparation of novel, amino-acid derived lipids for diverse applications including experimental antibiotics for human, animal, and plant diseases, and for imbuing lipid nanoparticles with desirable properties for drug delivery; and 2), the synthesis of perylene dyes for biophotonic and photo-harvesting applications. While investigating these topics, my group and I are intensely interested in student training at all levels.

近期论文

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Adelphe M. Mfuh; Mathew P. D. Mahindaratne; Audrey E. Yñigez-Gutierrez; Juan R. Ramos Dominguez; Jefferson T. Bedell; Carlos D. Garcia; George R. Negrete Acid-responsive nanospheres from an asparagine-derived amphiphile RSC Advances. 2015;5(12):8585-8590. 0 Mohammed J. Farooqi; Mark A. Penick; George R. Negrete; Lorenzo Brancaleon Interaction of human serum albumin with novel 3,9-disubstituted perylenes Protein Journal. 2013;32(6):493-504. 0 Djan Baffoe; Terrill D. Smith; Mark A. Penick; Mathew P. D. Mahindaratne; Lorenzo Brancaleon; George R. Negrete A Claisen rearrangement route to novel electron-rich perylene dyes Arkivoc. 2012;2012(6):112-118. 0 Karin Y. Chumbimuni-Torres; Ramon E. Coronado; Adelphe M. Mfuh; Carlos Castro-Guerrero; Maria Fernanda Silva; George R. Negrete; Rena Bizios; Carlos D. Garcia Adsorption of proteins to thin-films of PDMS and its effect on the adhesion of human endothelial cells RSC Advances. 2011;1(4):706-714. 13 John F. Fuini; Anand B. Surampudi; Mark A. Penick; Mathew P.D. Mahindaratne; George R. Negrete; Lorenzo Brancaleon The photophysical characterisation of novel 3,9-dialkyloxy- and diacyloxyperylenes Dyes and Pigments. 2011;88(2):204-211. 6 Adelphe M. Mfuh; Mathew P. D. Mahindaratne; Maritza V. Quintero; Frederick J. Lakner; Ande Bao; Beth A. Goins; William T. Phillips; George R. Negrete Novel asparagine-derived lipid enhances distearoylphosphatidylcholine bilayer resistance to acidic conditions Langmuir. 2011;27(8):4447-4455. 3 Terrill D. Smith; Mathew P. D. Mahindaratne; Mark A. Penick; George R. Negrete; Lee M. Daniels; Edward R. T. Tiekink 4,10-Diallyloxy-1,2,3,6b,7,8,9,12b-octahydroperylene Acta Crystallographica Section E: Structure Reports Online. 2010;66(1):o96. 1 Sandip K. Kundu; Mathew P. D. Mahindaratne; Brian Quinõnes; George R. Negrete; Edward R. T. Tiekink (2S,4S)-3-Acryloyl-6-oxo-2-phenylperhydropyrimidine-4-carboxylic acid Acta Crystallographica Section E: Structure Reports Online. 2010;66(1):o3. 1 Sandip K. Kundu; Mathew P. D. Mahindaratne; Maritza V. Quintero; Ande Bao; George R. Negrete One-pot reductive cyclization to antitumor quinazoline precursors Arkivoc. 2008;2008(2):33-42. 12 Mark A. Penick; Mathew P. D. Mahindaratne; Robert D. Gutierrez; Terrill D. Smith; Edward R. T. Tiekink; George R. Negrete Tandem Friedel-Crafts annulation to novel perylene analogues Journal of Organic Chemistry. 2008;73(16):6378-6381. 8 Mathew P. D. Mahindaratne; Brian A. Quiñones; Antonio Recio III; Eric A. Rodriguez; Frederick J. Lakner; George R. Negrete A fully-telescoped, aqueous, auxiliary-mediated asymmetric transformation Arkivoc. 2005;2005(6):321-328. 3 Mathew P. D. Mahindaratne; Brian A. Quiñones; Antonio Recio III; Eric A. Rodriguez; Frederick J. Lakner; George R. Negrete Salt, concentration, and temperature effects on an asparagine-based, aqueous Diels-Alder cycloaddition Tetrahedron. 2005;61(40):9495-9501. 8 Ande Bao; Beth Goins; Robert Klipper; George Negrete; William T. Phillips Direct 99mTc Labeling of Pegylated Liposomal Doxorubicin (Doxil) for Pharmacokinetic and Non-Invasive Imaging Studies Journal of Pharmacology and Experimental Therapeutics. 2004;308(2):419-425. 63 Ande Bao; Beth Goins; Robert Klipper; George Negrete; William T. Phillips 186Re-liposome labeling using 186Re-SNS/S complexes: In vitro stability, imaging, and biodistribution in rats Journal of Nuclear Medicine. 2003;44(12):1992-1999. 56 Mathew P. D. Mahindaratne; Hesham T. Y. Fahmy; Jesus A. Garcia; George R. Negrete Syntheses of cis- and trans-7-chloro-7,8,9,10-tetrahydrobenzo[a]pyren-8-ol: A remarkable solvent effect on epoxide hydrochlorination diastereoselectivity Synthetic Communications. 2003;33(8):1391-1398. 1 Ande Bao; Beth Goins; Robert Klipper; George Negrete; Mathew Mahindaratne; William T. Phillips A novel liposome radiolabeling method using 99mTc-" SNS/S" complexes: In vitro and in vivo evaluation Journal of Pharmaceutical Sciences. 2003;92(9):1893-1904. 43 Frederick J. Lakner; George R. Negrete A new and convenient chiral auxiliary for asymmetric Diels-Alder cycloadditions in environmentally benign solvents Synlett. 2002;(4):643-645. 16 Robert S. Murray; Vincent A. Boyd; Vincent M. Lynch; George R. Negrete Pyrimidinone conjugates for the assignment of the absolute configuration of α-chiral carboxylic acids by 1H-NMR Arkivoc. 2001;2001(11):58-73. 2 George R. Negrete; Manickam Bakthadoss Professor B. S. Thyagarajan: A tribute Arkivoc. 2001;2001(11):1-11. 0 Qi Song; George R. Negrete; Alan R. Wolfe; Keshi Wang; Thomas Meehan Synthesis and characterization of bay region halohydrins derived from benzo[a]pyrene diol epoxide and their role as intermediates in halide- catalyzed cis adduct formation Chemical Research in Toxicology. 1998;11(9):1057-1066.