Larionov, Oleg - University of Texas-San Antonio

个人简介

M.S. Higher Chemical College of the Russian Academy of Sciences, 2002 Ph.D. Georg-August University Gottingen, 2005 Postdoc Harvard University, 2007-2010. Max-Planck-Institut fur Kohlenforschung, Mulheim an der Ruhr, Germany, 2006-2007

研究领域

The research in my group spans methodology and complex molecule synthesis. In this context, the development of novel selective and efficient reactions will be followed by their implementation in the total synthesis of biologically active natural products and analogs, with a special focus on compounds targeting cancer. In our search for new reactions we strive to develop catalytic and generally applicable processes with potential to streamline present day synthetic approaches and solve their long-standing problems. In total synthesis we accentuate brevity, efficiency and flexibility in generation of molecular complexity.

近期论文

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Highly Regio- and Stereoselective Catalytic Synthesis of Conjugated Dienes and Polyenes. Nguyen, V. T.; Dang, H. T.; Pham, H. H.; Nguyen, V. D.; Flores-Hansen, C.; Arman, H. D.; Larionov, O. V. J. Am. Chem. Soc. 2018, 140, 8434–8438. 10.1021/jacs.8b05421 A Radical New Look for Alkene Carboboration. Jin, S.; Larionov, O. V. Chem 2018, 4, 1194–1207. 10.1016/j.chempr.2018.05.022 Efficient Synthesis of 3-Sulfolenes from Allylic Alcohols and 1,3-Dienes Enabled by Sodium Metabisulfite as a Sulfur Dioxide Equivalent. Dang, H. T.; Nguyen, V. T.; Nguyen, V. D.; Arman, H. D.; Larionov, O. V. Org. Biomol. Chem. 2018, 16, 3605–3609. 10.1039/c8ob00745d Antiviral Activity of Novel Quinoline Derivatives against Dengue Virus Serotype 2. de la Guardia, C; Stephens, D. E.; Dang, H. T.; Quijada, M.; Larionov, O. V.; Lleonart, R. Molecules 2018, 23, 672. 10.3390/molecules23030672 Photoinduced Carboborative Ring Contraction Enables Regio- and Stereoselective Synthesis of Multiply Substituted Five-Membered Carbocycles and Heterocycles. Jin, S.; Nguyen, V. T.; Dang, H. T.; Nguyen, D. P.; Arman, H. D.; Larionov, O. V. J. Am. Chem. Soc. 2017, 139, 11365–11368. (Highlighted in C&EN) 10.1021/jacs.7b07128 Transition Metal-Catalyzed C–H Functionalization of Heterocyclic N-Oxides. Stephens, D. E.; Larionov, O. V. Top. Heterocycl. Chem. 2017, 53, 59–84. 10.1007/7081_2017_1 Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-β Aggregation in Alzheimer’s Disease. Lakey-Beitia, J.; González, Y.; Doens, D.; Stephens, D. E.; Santamaría, R.;, Murillo, E.; Gutiérrez, M.; Fernández, P. L.; Rao, K. S. Larionov, O. V.; Durant-Archibold, A. A. J. Alzheimer’s Dis. 2017, DOI: 10.3233/JAD-170071. 10.3233/JAD-170071 Metal- and Additive-Free Photoinduced Borylation of Haloarenes. Mfuh, A. M.; Schneider, B. D.; Cruces, W.; Larionov, O. V. Nat. Protoc. 2017, 12, 604–610. 10.1038/nprot.2016.184 Identification of Inhibitors of CD36-Amyloid Beta Binding as Potential Agents for Alzheimer’s Disease. Doens, D.; Valiente, P. A.; Mfuh, A. M.; Vo, A. X. T.; Tristan, A.; Carreño, L.; Quijada, M.; Nguyen, V. T.; Perry, G.; Larionov, O. V.; Lleonart, R.; Fernández, P. L. ACS Chem. Neurosci. 2017, 10.1021/acschemneuro.6b00386. 10.1021/acschemneuro.6b00386 Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues. Jans, P. E.; Mfuh, A. M.; Arman, H. D.; Shaffer, C. V.; Larionov, O. V.; Mooberry, S. L. J. Nat. Prod. 2017, 80, 676–683. 10.1021/acs.jnatprod.6b00963 Organocatalytic Synthesis of Methylene-Bridged N-Heterobiaryls. Stephens, D. E.; Nguyen, V. T.; Chhetri, B.; Clark, E. R.; Arman, H. D.; Larionov, O. V. Org. Lett. 2016, 18, 5808–5811. 10.1021/acs.orglett.6b02719 Mechanistic Insights into the Potassium tert-Butoxide-Mediated Synthesis of N-Heterobiaryls. Stephens, D. E.; Lakey-Beitia, J.; Burch, J. E.; Arman, H. D.; Larionov, O. V. Chem. Commun. 2016, 52, 9945–9948. 10.1039/C6CC04816A Additive- and Metal-Free, Predictably 1,2- and 1,3-Regioselective, Photoinduced Dual C–H/C–X Borylation of Haloarenes. Mfuh, A. M.; Nguyen, V. T.; Chhetri, B.; Burch, J. E.; Doyle, J. D.; Nesterov, V. N.; Arman, H. D.; Larionov, O. V. J. Am. Chem. Soc. 2016, 138, 8408–8411. 10.1021/jacs.6b05436 Insights into the Structural Patterns of the Antileishmanial Activity of Bi- and Tricyclic N-Heterocycles. Herrera, L.; Stephens, D. E.; D’Avila, A.; George, K. A.; Arman, H. D.; Zhang, Y.; Perry, G.; Lleonart, R.; Larionov, O. V.; Fernández, P. L. Org. Biomol. Chem. 2016, 14, 7053–7060. 10.1039/C6OB01149G Scalable, Metal- and Additive-Free, Photoinduced Borylation of Haloarenes and Quaternary Arylammonium Salts. Mfuh, A. M.; Doyle, J. D.; Chhetri, B.; Arman, H. D.; Larionov, O. V. J. Am. Chem. Soc. 2016, 139, 2985–2988. 10.1021/jacs.6b01376 Recent Advances in the C–H-Functionalization of the Distal Positions in Pyridines and Quinolines. Stephens, D. E.; Larionov, O. V. Tetrahedron 2015, 71, 8683–8716. 10.1016/j.tet.2015.08.034