孙斌 - 山东大学 - 国家糖工程技术研究中心

个人简介

2001.09-2005.07，山东大学，药学院药学专业，理学学士； 2005.09-2010.07，山东大学，药学院药物化学专业，医学博士（导师：娄红祥教授）； 2008.09-2009.09，普渡大学，药学院药物化学专业，联合培养博士研究生。 2010.07-至今，山东大学国家糖工程技术研究中心，讲师，副教授； 2018年获山东大学“青年学者未来计划”人才计划支持。

研究领域

1. 抗肿瘤和抗真菌活性天然产物的合成、衍生物制备和作用机制研究； 2. 一氧化氮供体型化合物的设计、合成和抗肿瘤活性研究； 3. 抗凝血创新药物的研究与开发。

近期论文

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1. Xiaoyu Zhao#, Bin Sun#, Hongbo Zheng, Jun Liu, Xiaoning Wang*, Hongxiang Lou*, Synthesis and biological evaluation of 6-hydroxyl C-aryl glucoside derivatives as novel sodium glucose co-transporter 2 (SGLT2) inhibitors, Bioorganic & Medicinal Chemistry Letters, 2018, 28: 2201-2205. 2. Changyi Cui, Jun Liu, Hongbo Zheng, Xueyang Jin, Xiaoyu Zhao, Wenqiang Chang, Bin Sun*, Hongxiang Lou*, Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans, Bioorganic & Medicinal Chemistry Letters, 2018, 28: 1545-1549. 3. Jun Liu#, Bin Sun#, Xiaoyu Zhao, Jie Xing, Yanhui Gao, Wenqiang Chang, Jianbo Ji, Hongbo Zheng, Changyi Cui, Aiguo Ji*, Hongxiang Lou*, Discovery of potent orally active protase-activated receptor 1 (PAR1) antagonist based on andrographolide, Journal of Medicinal Chemistry, 2017, 60 (16): 7166-7185 4. Bin Sun#, Jun Liu#, Yun Gao, Hongbo Zheng, Lin Li, Qingwen Hu, Huiqing Yuan, Hongxiang Lou*, Design, synthesis, and biological evaluation of nitrogen-containing macrocyclic bisbibenzyl derivatives as potent anticancer agents by targeting the lysosome, European Journal of Medicinal Chemistry, 2017, 136:603-618 5. Bin Sun, Lin Li, Qingwen Hu, Hongbo Zheng, Hui Tang, Huanmin Niu, Huiqing Yuan, Hongxiang Lou*, Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents, European Journal of Medicinal Chemistry, 2017, 129:186-208 6. Bin Sun, Ming Zhang, Ying Li, Qingwen Hu, Hongbo Zheng, Wenqiang Chang, Hongxiang Lou*, Synthesis of riccardin D derivatives as potent antimicrobial agents, Bioorganic & Medicinal Chemistry Letters, 2016, 26 (15): 3617-3620 7. Bin Sun, Lin Li, Qingwen Hu, Fei Xie, Hongbo Zheng, Huanmin Niu, Huiqing Yuan, Hongxiang Lou*, Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors, European Journal of Medicinal Chemistry, 2016, 121: 484-499 8. Xigong Liu#, Bin Sun#, Zhiyu Xie, Xiaojun Qin, Lei Liu, Hongxiang Lou*, Manganese dioxide-methanesulfonic acid promoted direct dehydrogenative alkylation of sp3 C-H bonds adjacent to a heteroatom, Journal of Organic Chemistry, 2013, 78 (7): 3104-3112 9. Juan Jiang #, Bin Sun#, Yanyan Wang, Min Cui, Li Zhang, Changzhi Cui, Yanfeng Wang, Xigong Liu, Hongxiang Lou*, Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents, Bioorganic & Medicinal Chemistry, 2012, 20 (7): 2382-2391 10. Guangmin Xi#, Bin Sun#, HuiHui Jiang, Feng Kong, Huiqing Yuan, Hongxiang Lou*, Bisbibenzyl derivatives sensitize vincristine- resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity, Bioorganic & Medicinal Chemistry, 2010, 18 (18): 6725-6733 11. Bin Sun, Juma Hoshino, Katie Jermihov, Laura Marler, John M. Pezzuto, Andrew D. Mesecar, Mark Cushman, Synthesis, and Biological Evaluation of Resveratrol Analogues as Aromatase and Quinone Reductase 2 Inhibitors for Chemoprevention of Cancer, Bioorganic & Medicinal Chemistry, 2010, 18 (14): 5352-5366 12. Bin Sun, Huiqing Yuan, Guangmin Xi, Yudao Ma*, Hongxiang Lou*, Synthesis and multidrug resistance reversal activity of dihydroptychantol A and its novel derivatives, Bioorganic & Medicinal Chemistry, 2009, 17 (14): 4981-4989