刘现伟 - 山东大学 - 国家糖工程技术研究中心

个人简介

2009年7月至今，受聘于山东大学国家糖工程技术研究中心，从事科研教学工作。 2003年9月至2009年6月，硕博连读研究生，山东大学微生物技术国家重点实验室，微生物学专业，获理学博士学位。主要从事微生物多糖生物合成相关酶类的生化研究，以及酶法合成寡糖研究。研究生学习期间，2007年2月至2009年2月，在美国俄亥俄州立大学（The Ohio State University）生物化学和化学院交流访问。 1999年9月至2003年6月，本科生，山西大学生命科学学院，生物科学专业，获理学学士学位。

研究领域

糖化学生物学，包括糖及糖缀合物的化学酶法合成，糖及蛋白的化学标记和修饰，糖及蛋白的生物学功能及应用研究等。

近期论文

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(1) Jinfeng Ye#, Xian-wei Liu#, Peng Peng, Wen Yi, Xi Chen, Fengshan Wang, Hongzhi Cao*, Diversity-Oriented Enzymatic Modular Assembly of ABO Histo-blood Group Antigens, ACS Catalysis, 2016, 6 (12): 8140-8144 (2) Xian-wei Liu, Chengfeng Xia, Lei Li, Wan-yi Guan, Nicholas Pettit, Hou-cheng Zhang, Min Chen*, Peng George Wang, Characterization and synthetic application of a novel β1,3-galactosyltransferase from Escherichia coli O55:H7, Bioorganic & Medicinal Chemistry, 2009, 17(14): 4910-4915 (1) Wenjing Shang, Yafei Zhai, Zhongrui Ma, Gongjin Yang, Yan Ding, Donglei Han, Jiang Li, Houcheng Zhang, Jun Liu, Peng George Wang, Xian-wei Liu*, Min Chen*, Production of human blood group B antigen epitope conjugated protein in Escherichia coli and utilization of the adsorption blood group B antibody, Microbial Cell Factories, 2016, 15: 138 (2) Yafei Zhai, Donglei Han, Ying Pan, Shuaishuai Wang, Junqiang Fang, Peng Wang, Xian-wei Liu*, Enhancing GDP-fucose production in recombinant Escherichia coli by metabolic pathway engineering, Enzyme and Microbial Technology, 2015, 69: 38-45 (3) Junqiang Fang, Mengyang Xue, Guofeng Gu, Xian-wei Liu*, Peng George Wang, A chemoenzymatic route to synthesize unnatural sugar nucleotides using a novel N-acetylglucosamine-1-phosphate pyrophosphorylase from Camphylobacter jejuni NCTC 11168, Bioorganic & Medicinal Chemistry Letters, 2013, 23(15): 4303-4307 (4) Mengyang Xue, Wanyi Guan, Yang Zou, Junqiang Fang*, Xian-wei Liu*, Peng George Wang, Fengshan Wang, Investigation of the nucleotide triphosphate substrate specificity of Homo sapiens UDP-N-acetylgalactosamine pyrophosphorylase (AGX1), Bioorganic & Medicinal Chemistry Letters, 2012, 22 (12): 3957-3961 (5) Yafei Zhai, Min Liang, Junqiang Fang, Xiaoyue Wang, Wanyi Guan, Xian-wei Liu*, Peng Wang, Fengshan Wang, NahK/GlmU fusion enzyme: Characterization and one-step enzymatic synthesis of UDP-N-acetylglucosamine, Biotechnology Letters, 2012, 34(7): 1321-1326 (6) Min Liang, Min Chen, Xinying Liu, Yafei Zhai, Xian-wei Liu*, Houcheng Zhang*, Min Xiao, Peng Wang, Bioconversion of D-galactose to D-tagatose: continuous packed bed reaction with an immobilized thermostable L-arabinose isomerase and efficient purification by selective microbial degradation, Applied Microbiology and Biotechnology, 2012, 93(4): 1469-1474 (7) Junqiang Fang, Wanyi Guan, Li Cai, Guofeng Gu*, Xianwei Liu*, Peng George Wang, Systematic study on the broad nucleotide triphosphate specificity of the pyrophosphorylase domain of the N-acetylglucosamine-1-phosphate uridyltransferase from Escherichia coli K12, Bioorganic & Medicinal Chemistry Letters, 2009, 19(22): 6429-6432