祁庆生 - 山东大学 - 国家糖工程技术研究中心

个人简介

德国明斯特大学微生物系博士，2001年被聘为德国开姆尼茨工业大学生物工程系课题组负责人。2004年回国任山东大学微生物技术国家重点实验室教授，博士生导师；山东大学国家糖工程中心研究员。教育部新世纪优秀人才。《生物工程学报》编辑，生物化学学会复合糖专业委员会委员。现在主持国家自然科学基金，教育部重点项目，国家863项目, 973子项目等多项。在包括《Applied Environmental Microbiology》,《Journal of Biological Chemistry》,《FEMS Microbiology Letters》在内的国际著名学术期刊上发表SCI论文40余篇，总被引用次数250多次。获得专利2项，申请4项。

研究领域

1. 通过代谢途径的建立和改造实现生物基化学品及生物可降解聚合物的合成。通过改造微生物的代谢，在重组大肠杆菌中生产重要工业产品，主要包括聚羟基脂肪酸、琥珀酸等有机酸。2. 通过改造微生物表达系统来生产糖基化改造的人源化糖蛋白和抗体以及稀有糖类；利用代谢工程合成小分子糖药物。药物的环糊精，脂质体包裹及运输。3. 建立微生物生物合成代谢的调控方法。通过全调控实现微生物（主要是大肠杆菌和酵母）抗性的提高及表达代谢能力的提高。研究微生物代谢的机理。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Kang, Z., Wang, Q., Zhang, H., Qi, Q* (2008) Construction of a stress-induced system in Escherichia coli for efficient polyhydroxyalkanoates production, Appl. Microbiol. Biotechnol. DOI 10.1007/s00253-008-1428-z 2. Xin, F., Wang, S., Song, L., Liang, Q., Qi, Q* (2008) Molecular identification and characterization of peptide: N-glycanase from Schizosaccharomyces pombe. Biochem Biophys Res Commun, online (doi:10.1016/j.bbrc.2008.02.017) 3. Wang, Q., Li, L., Chen, M., Qi, Q. Wang, PG. (2008) Construction of a Novel Pichia pastoris Cell-Surface Display System Based on the Cell Wall Protein Pir1.Curr Microbiol. 56:352-357. 4. 信封学，王鹏，祁庆生（2008）粟酒裂殖酵母N-糖酰胺酶在大肠杆菌中的表达、纯化及活性分析，24（4）。 5. Qingjie Wang#, Lei Li#, Min Chen, Peng George Wang*, Qingsheng Qi (2007) Construction of a novel system for cell surface display of heterologous protein on Pichia pastoris Biotechnology Lett. 29:1561-1566. 6. Dawei Zhang, Peng George Wang*, Qingsheng Qi* (2007) A two-step fermentation process for efficient production of penta-N-acetyl-chitopentaose in recombinant Escherichia coli Biotechnology lett.29:1729-1733. 7. Jungang Zhou, Houcheng Zhang, Xianwei Liu, Min Chen, Peng George Wang*, Qingsheng Qi* Deficiency in N-glycan outer chain elongation accelerates cell death in Saccharomyces cerevisiae. Current Microbiology. 55:198-204. 8. Li, R., Chen, Q., Wang, P., Qi, Q*. (2007) A novel-designed Escherichia coli for the production of various polyhydroxyalkanoates from inexpensive substrate mixture. Appl. Microbiol Biotechnol. 75:1103-1109. 9. Qi,Q. Mokhtar MN., Zimmermann, W. (2007) Effect of ethanol on the synthesis of large-ring cyclodextrins by cyclodextrin glucanotransferases J Incl Phenom Macrocycl Chem 57:95–99 10. Su, Y., Zhang, H., Gu, L., Chen, M., Xiao, M., Wang, PG., Qi, Q.* (2007) Construction of engineered yeast for the hydrolysis of glycoprotein with N-glycosidase on the cell surface. Enzyme and Microbiol Technology, 40: 1496-1502. 11. Wang S, Wang PG, Qi Q.* (2007) Influence of Substrate Conformation on the Deglycosylation of Ribonuclease B by Recombinant Yeast Peptide:N-glycanase. Acta Biochim Biophys Sin (Shanghai).39(1):8-14. 12. Li, R., Zhang, H., Qi, Q.* (2007) Production of polyhydroxyalkanoates in recombinant Escherichia coli. Bioresource Technol. 98: 2313-2320. 13. Wang, Z., Qi, Q.,* Wang, P.(2006) Engineering of Cyclodextrin Glucanotransferase on the Cell Surface of Yeast for improved cyclodextrin production. Appl. Environ. Microbiol. 72: 1873-1877. 14. Zhang, H., Wang, P. Qi, Q.* (2006) Molecular effect of FadD on the regulation and metabolism of fatty acid in Escherichia coli. FEMS Microbioloy Lett. 259:249-253. 15. Chen C, Shi Y, Li S, Qi Q, Gu L, Song J, Wang PG. (2006) A glycosylated nitric oxide donor, beta-Gal-NONOate, and its site-specific antitumor activity. Arch Pharm (Weinheim). 339(7):366-71. 16. Chen, C., Shi, Y., Song, J., Qi, Q., Gu L., Wang, PG. (2006) Delivery of Nitric Oxide Released from β-Gal-NONOate Activation by β-Galactosidase and Its Activity against Escherichia coli Biological & Pharmaceutical Bulletin, 26, 1239-1241. 17. Zhang, H., Bi, J., Chen, C. Huang, G., Qi, Q., Xiao, M. and Wang, PG (2006) Immobilization of UDP- galactose 4- epimerase from Escherichia coli on the Yeast Cell Surface. Biosci. Biotechnol. Biochem. 70:2303-6.