高健 - 山东大学 - 国家糖工程技术研究中心

个人简介

教育经历： 2006.09-2012.06，山东大学，药学院，医学博士，导师：娄红祥教授 2001.09-2006.06，泰山医学院，药学系，医学学士科研与学术工作经历： 2016.04-至今，山东大学，国家糖工程技术研究中心，研究员 2012.06-2016.04，美国韦恩州立大学，化学系，博士后，导师：郭忠武教授

研究领域

1. 具有重要生物活性的复杂寡糖、糖脂和糖蛋白等分子的全合成与活性研究；2. 新型抗细菌糖疫苗研究；3. 糖化学合成方法学研究.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Y. Zhang, S. Zhou, X. Wang, H. Zhang, Z. Guo,* J. Gao.* A new method for α-specific glucosylation and its application to the one-pot synthesis of a branched α-glucan. Org. Chem. Front. 2019, DOI: 10.1039/c8qo01177j. 2. L. Shao, H. Zhang, Y. Li, G. Gu, F. Cai, Z. Guo,* J. Gao.* Chemical synthesis of the repeating unit of type II group B Streptococcus capsular polysaccharide. J. Org. Chem. 2018, 83, 5920-5930. 3. J. Gao, Z. Guo. Progress in the synthesis and biological evaluation of lipid A and its derivatives. Med. Res. Rev. 2018, 38, 556-601. 4. J. Gao, Z. Guo. Synthetic studies of GPI-anchored peptides, glycopeptides, and proteins. RSC Chemical Biology of Glycoproteins, 2017, 253-281. 5. J. Gao, Z. Zhou, J. Guo, Z. Guo. Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins. Chem. Commun. 2017, 53, 6227-6230. 6. J. Gao, Z. Guo. Chemical synthesis of the repeating unit of type V group B Streptococcus capsular polysaccharide. Org. Lett. 2016, 18, 5552-5555. 7. L. Lu,# J. Gao,# Z. Guo. Labeling cell surface GPIs and GPI-anchored proteins through cell metabolic engineering with artificial inositol derivatives. Angew. Chem. Int. Ed. 2015, 54, 9679-9682. 8. J. Gao, G. Liao, L. Wang, Z. Guo. Synthesis of a miniature lipoarabinomannan. Org. Lett. 2014, 16, 988-991. 9. J. Gao, Z. Guo. Synthesis of a tristearoyl lipomannan via preactivation-based iterative glycosylation. J. Org. Chem. 2013, 78, 12717-12725. 10. X. Zan,# J. Gao,# G. Gu, S. Liu, B. Sun, L. Liu, H. Lou. Synthesis and cytotoxic effect of pseudodiosgenyl saponins with thio-ring F. Bioorg. Med. Chem. Lett. 2014, 24, 1600-1604. 11. J. Gao, X. Li, G. Gu, S. Liu, M. Cui, H. Lou. Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities. Bioorg. Med. Chem. Lett. 2012, 22, 2396-2400. 12. J. Gao, X. Li, G. Gu, B. Sun, M. Cui, M. Ji, H. Lou. Efficient synthesis of trisaccharide saponins and their tumor cell killing effects through oncotic necrosis. Bioorg. Med. Chem. Lett. 2011, 21, 622-627. 13. Y. Wang,# J. Gao,# G. Gu, G. Li, C. Cui, B. Sun, H. Lou. In situ RBL receptor visualization and its mediated anticancer activity for solasodine rhamnosides. ChemBioChem. 2011, 12, 2418-2420.