迟连利 - 山东大学 - 国家糖工程技术研究中心

个人简介

教育经历 1995年-1999年在中国海洋大学食品科学与工程本科专业学习，获理学学士学位 1999年-2002年在中国海洋大学食品与药物研究所攻读硕士研究生，获工学硕士学位 2002年进入美国University of Iowa药学专业攻读博士学位，2003年随导师转入Rensselaer Polytechnic Institute化学与化学生物系分析化学专业，2006年12月获博士学位工作经历 2005年曾在美国新泽西葛兰素史克公司（GlaxoSmithKline）担任实习顾问，参与戒烟药的研发 2007年起在美国芝加哥雅培公司（Abbott Laboratories）担任资深科学家，主要从事疾病相关蛋白和糖链标志物的研究，参与了生殖细胞癌hCG、急性肾损伤NGAL、心血管疾病PlGF和丙肝HCV等诊断产品的研发 2010年被山东大学国家糖工程技术研究中心聘为教授、博士生导师，主要从事生物质谱新方法开发、低分子肝素等生化药物结构确证以及糖缀合物参与疾病发生发展机制等方面的研究。已发表SCI收录论文50余篇，授权国际PCT发明专利2项，国家发明专利5项

研究领域

1、生物质谱技术研究多糖和蛋白的结构与功能 2、重大疾病的蛋白组学和糖组学；诊断标志物及新药靶点研究 3、蛋白药物、糖药物和中药的应用开发研究

近期论文

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A. Sheng, Q. Chen, M. Yu, R. Xiao, T. Zhang, Z. Wang, R. J. Linhardt, X. Sun*, L. Jin*, L. Chi*, Coupling liquid chromatography and tandem mass spectrometry to electrophoresis for in-depth analysis of glycosaminoglycan drugs: heparin and the multicomponent sulodexide, Analytical Chemistry, 2021, 93, 1433-1442. （IF = 8.008） B. Zhang, L. Chi*, Chondroitin sulfate/dermatan sulfate-protein interactions and their biological functions in human diseases: implications and analytical tools, Frontiers in Cell and Developmental Biology, 2021, 9, 693563. （IF = 6.081） D. Shi, A. Sheng, L. Chi*, Glycosaminoglycan-protein interactions and their roles in human disease, Frontiers in Molecular Biosciences, 2021, 8, 639666. （IF = 6.113） H. Qiu, L. Jin, J. Chen, M. Shi, F. Shi, M. Wang, D. Li, X. Xu, X. Su, X. Yin, W. Li, X. Zhou, R. J. Linhardt, Z. Wang, L.Chi*, Q. Zhang*, Comprehensive glycomic analysis reveals that human serum albumin glycation specifically affects the pharmacokinetics and efficacy of different anticoagulant drugs in diabetes, Diabetes, 2020, 69, 760-770.（IF = 9.337） L. Ding, S. Xie, S. Zhang, H. Shen, H. Zhong, D. Li, P. Shi*, L. Chi*, Q. Zhang*, Delayed comparison and Apriori algorithm (DCAA): a tool for discovering protein-protein interactions from time-series phosphoproteomic data, Frontiers in Molecular Biosciences, 2020, 7, 606570. （IF = 6.113） X. Xu, H. Qiu, F. Shi, Z. Wang, X. Wang, L. Jin, L. Chi*, Q. Zhang*, The protein S-nitrosylation of splicing and translational machinery in vascular endothelial cells is susceptible to oxidative stress induced by oxidized low-density lipoprotein, Journal of Proteomics, 2019, 195, 11-22. （IF = 3.855） Z. Wang, T. Zhang, S. Xie, X. Liu, H. Li, R.J. Linhardt, L. Chi*, Sequencing the oligosaccharide pool in the low molecular weight heparin dalteparin with offline HPLC and ESI-MS/MS, Carbohydrate Polymers, 2018, 183, 81-90. （IF = 10.723） S. Xie, Y. Guan, P. Zhu, F. Li, M. Yu, R.J. Linhardt, L. Chi*, Lan Jin*, Preparation of low molecular weight heparins from bovine and ovine heparins using nitrous acid degradation, Carbohydrate Polymers, 2018, 197, 83-91. （IF = 10.723） Z. Wang, L. Chi*, Recent advances in mass spectrometry analysis of low molecular weight heparins, Chinese Chemical Letters, 2018, 29, 11-18. （IF = 8.455） X. Sun, Z. Guo*, M. Yu, C. Lin, A, Sheng, Z. Wang, R.J. Linhardt, L. Chi*, Hydrophilic interaction chromatography-multiple reaction monitoring mass spectrometry method for basic building block analysis of low molecular weight heparins prepared through nitrous acid depolymerization, Journal of Chromatography A, 2017, 1479, 121-128. （IF = 4.601） X. Liu, K. St Ange, X. Wang, L. Lin, F. Zhang, L. Chi*, R.J. Linhardt*, Parent heparin and daughter LMW heparin correlation analysis using LC-MS and NMR, Analytica Chimica Acta, 2017, 961, 91-99. （IF = 6.911） X. Liu, K. St Ange, L. Lin, F. Zhang, L. Chi*, R.J. Linhardt*, Top-down and bottom-up analysis of commercial enoxaparins, Journal of Chromatography A, 2017, 1480, 32-40. （IF = 4.601） X. Li, F. Shi*, L. Gong, B. Hang, D. Li, L. Chi*, Species-specific identification of collagen components in Colla Corii Asini using a nano-liquid chromatography tandem mass spectrometry proteomics approach, International Journal of Nanomedicine, 2017, 12, 4443-4454. （IF = 7.033） J. Yang, L. Chi*, Characterization of structural motifs for interactions between glycosaminoglycans and proteins, Carbohydrate Research, 2017, 452, 54-63. （IF = 2.975） X. Sun, A. Sheng, X. Liu, F. Shi, L. Jin, S. Xie, F. Zhang, R.J. Linhardt, L. Chi*, Comprehensive identification and quantitation of basic building blocks for low-molecular weight heparin, Analytical Chemistry, 2016, 88, 7738-7744. （IF = 8.008） Y. Guan, X. Xu, X. Liu, A. Sheng, L. Jin, R.J. Linhardt, L. Chi*, Comparison of low-molecular-weight heparins prepared from bovine lung heparin and porcine intestine heparin, Journal of Pharmaceutical Sciences, 2016, 105, 1843-50. （IF = 3.784） D. Li, P. Zhang, F. Li, L. Chi, D. Zhu, Q. Zhang*, L. Chi*, Recognition of N-glycoforms in human chorionic gonadotropin by monoclonal antibodies and their interaction motifs, Journal of Biological Chemistry, 2015, 290, 22715-22723. （IF = 5.486） X. Bai, D. Li, J. Zhu, Y. Guan, Q. Zhang, L. Chi*, From individual proteins to proteomic samples: characterization of O-glycosylation sites in human chorionic gonadotropin and human-plasma proteins. Analytical and Bioanalytical Chemistry, 2015, 407, 1857-1869.（IF = 4.478） X. Xu, D. Li, L. Chi, X. Du, X. Bai, L. Chi*, Fragment profiling of low molecular weight heparins using reversed phase ion pair liquid chromatography-electrospray mass spectrometry, Carbohydrate Research, 2015, 407, 26-33. （IF = 2.975） D. Li, L. Chi, L. Jin, X. Xu, X. Du, S. Ji, L. Chi*, Mapping of low molecular weight heparins using reversed phase ion pair liquid chromatography-mass spectrometry, Carbohydrate Polymers, 2014, 99, 339-344. （IF = 10.723）