Paegel, Brian - The Scripps Research Institute

研究领域

All of contemporary biology and most chemistry is compartmentalized. For example, beakers, flasks or microplate wells spatially segregate individual chemical reactions. Likewise, membranes compartmentalize individual cells and subcellular organelles, tissues and organs organize the metabolism of multi-cellular organisms, and even organisms themselves are merely the vehicles for selfishly replicating genes in a population. Reaction vessels, seemingly innocuous entities, actually play starring roles in activities ranging from drug discovery laboratory automation and technology development to natural selection and the origins of life on Earth. We are broadly interested in the rational construction of microscopic reaction vessels and the interesting chemical and biological operations that we can conduct within their confines.

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Price AK, MacConnell AB, Paegel BM (2014) Microfluidic Bead Suspension Hopper. Anal Chem 86: 5039-5044. Matosevic S, Paegel, BM (2013) Layer-by-layer cell membrane assembly. Nat Chem 5: 958-963. Matosevic S, Paegel BM (2011) Stepwise synthesis of giant unilamellar vesicles on a microfluidic assembly line. J Am Chem Soc 133:2798-2800. Paegel BM (2010) Microfluidic landscapes for evolution. Curr Opin Chem Biol 14:568-573. Paegel BM, Joyce GF (2010) Microfluidic compartmentalized directed evolution. Chem Biol 17:717-724. Paegel BM, Joyce GF (2008) Darwinian evolution on a chip. PLoS Biol 6:900-906. Paegel BM, Grover WH, Skelley AM, Mathies RA, Joyce GF (2006) Microfluidic serial dilution circuit. Anal Chem 78:7522-7527. Paegel BM, Blazej RG, Mathies RA (2003) Microfluidic devices for DNA sequencing: sample preparation and electrophoretic analysis. Curr Opin Biotechnol 14:42-50. Paegel BM, Yeung SHI, Mathies RA (2002) Microchip bioprocessor for integrated nanovolume sample purification and DNA sequencing. Anal Chem 74:5092-5098. Paegel BM, Emrich CA, Wedemayer GJ, Scherer JR, Mathies RA (2002) High throughput DNA sequencing with a microfabricated 96-lane capillary array electrophoresis bioprocessor. Proc Natl Acad Sci USA 99:574-579. Paegel BM, Hutt LD, Simpson PC, Mathies RA (2000) Turn geometry for minimizing band broadening in microfabricated capillary electrophoresis channels. Anal Chem 72:3030-3037.