Kaddoumi, Amal Khalil - University of Louisian at Monroe - Department of Basic Pharmaceutical Sciences

个人简介

2001 - 2004 Ph.D., Pharmaceutical Sciences School of Pharmaceutical Sciences Nagasaki University Nagasaki, Japan 1999 - 2001 MSc., Pharmaceutical Sciences School of Pharmaceutical Sciences Nagasaki University Nagasaki, Japan 1998 - 1999 Research Student Nagasaki University Nagasaki, Japan

研究领域

My research interest is to investigate the role of membrane transport proteins in determining drugs and endogenous molecules disposition and their role in neurological diseases, mainly Alzheimer’s disease. Investigating and understanding transport proteins is fundamental to facilitate therapeutic development and delivery. Transport proteins are widely acknowledged as important determinants governing absorption, clearance, and, in many cases, extent of entry into target organs. There is also a greater appreciation that altered transporter function, whether due to aging, genetic polymorphisms, drug interactions, or environmental factors such as dietary constituents, can result in unexpected adverse effects. Such effects are in part due to the interplay between various uptake and efflux transport proteins with overlapping functional capabilities that can appear as marked inter-individual variability in drugdisposition in vivo, and possible susceptibility to diseases.

近期论文

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Mohamed LA, Qosa H, Kaddoumi A. Age-Related Decline in Brain and Hepatic Clearance of Amyloid-beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats. ACS Chem Neurosci. 2015 Mar 17. [Epub ahead of print] Alqahtani S, Simon L, Astete CE, Alayoubi A, Sylvester PW, Nazzal S, Shen Y, Xu Z, Kaddoumi A, Sabliov CM. Cellular uptake, antioxidant and antiproliferative activity of entrapped α-tocopherol and γ-tocotrienol in poly (lactic-co-glycolic) acid (PLGA) and chitosan covered PLGA nanoparticles (PLGA-Chi). J Colloid Interface Sci. 2015;445:243-51. Gill KK, Kaddoumi A, Nazzal S. PEG-lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication. J Drug Target. 2015;23(3):222-31. Alqahtani S, Kaddoumi A. Vitamin e transporters in cancer therapy. AAPS J. 2015 ;17(2):313-22 Alqahtani S, Alayoubi A, Nazzal S, Sylvester PW, Kaddoumi A. Enhanced solubility and oral bioavailability of γ-tocotrienol using a self-emulsifying drug delivery system (SEDDS). Lipids. 2014;49(8):819-829 Qosa H, LeVine H 3rd, Keller JN, Kaddoumi A. Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model. Biochim Biophys Acta. 2014; 1842(9):1806-1815 Mohamed LA, Kaddoumi A. Tacrine Sinusoidal Uptake and Biliary Excretion in Sandwich-Cultured Primary Rat Hepatocytes. Journal of Pharmacy and Pharmaceutical Sciences. 2014; 17(3):427-438 Qosa H, Abuasal BS, Romero IA, Weksler B, Couraud PO, Keller JN, Kaddoumi A. Differences in amyloid-β clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling. Neuropharmacology. 2014;79:668-78 Kathawala RJ, Sodani K, Chen K, Patel AS, Abuznait AH, Anreddy N, Sun YL, Kaddoumi A, Ashby CR Jr, Chen ZS. Masitinib Antagonizes ATP-Binding Cassette Subfamily C Member 10-Mediated Paclitaxel Resistance: A Preclinical Study. Mol Cancer Ther. 2014 Jan 15. [Epub ahead of print]. PMID: 24431074 Alayoubi A, Alqahtani S, Kaddoumi A, Nazzal S. Effect of PEG Surface Conformation on Anticancer Activity and Blood Circulation of Nanoemulsions Loaded with Tocotrienol-Rich Fraction of Palm Oil. AAPS J. 2013;15(4):1168-79 Mohamed LA, Kaddoumi A. In vitro Investigation of Amyloid-beta Hepatobiliary Disposition in Sandwich Cultured Primary Rat Hepatocytes. Drug Metab Dispos. 2013;41(10):1787-96 Alqahtani S, Mohamed LA, Kaddoumi A. Experimental models for predicting drug absorption and metabolism. Expert Opin Drug Metab Toxicol. 2013;9(10):1241-54 Alqahtani S, Alayoubi A, Nazzal S, Sylvester PW, Kaddoumi A. Nonlinear absorption kinetics of self-emulsifying drug delivery systems (SEDDS) containing tocotrienols as lipophilic molecules: in vivo and in vitro studies. AAPS J. 2013;15(3):684-95 Abuznait AH, Qosa H, Busnena B, El Sayed KA, Kaddoumi A. Olive Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In-vitro and In-vivo Studies. ACS Chem. Neurosci. 2013; 4(6):973-82 Akl MR, Ayoub NM, Abuasal B, Kaddoumi A, Sylvester PW. Sesamin Synergistically Potentiates the Anticancer Effects of gamma-Tocotrienol in Mammary Cancer Cell Lines. Fitoterapia. 2012. Accepted Abuznait, AH, Kaddoumi, A. Role of ABC Transporters in the Pathogenesis of Alzheimer’s Disease.ACS Chem. Neurosci. 2012; 3(11):820-31 Tiwari AK, Sodani K, Dai CL, Abuznait AH, Singh S, Xiao ZJ, Patel A, Talele TT, Fu L, Kaddoumi A, Gallo JM, Chen ZS. Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models. Cancer Lett. 2012. (PMID: 23063650) Qosa H, Abuznait AH, Hill RA, Kaddoumi A. Enhanced brain amyloid-beta clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease. Journal of Alzheimer’s Disease. 2012; 31(1):151-65 Abuasal BS, Qosa H, Sylvester PW, Kaddoumi A. Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: in-vitro, in-situ, and in-vivo studies. Biopharm Drug Dispos. 2012; 33 (5):246-56 Gill KK, Kaddoumi A, Nazzal S. Mixed Micelles of PEG2000-DSPE and Vitamin-E TPGS for Concurrent Delivery of Paclitaxel and Parthenolide: Enhanced Chemosenstization and Antitumor Efficacy against Non-Small Cell Lung Cancer (NSCLC) Cell Lines. Eur J Pharm Sci. 2012; 46(1-2):64-71 Abuasal BS, Bolger MB, Walker DK, Kaddoumi A. In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate. Mol Pharm. 2012; 9(3):492-504 Abuasal BS, Lucas C, Peyton B, Alayoubi A, Nazzal S, Sylvester PW, Kaddoumi A. Enhancement of Intestinal Permeability Utilizing Solid Lipid Nanoparticles Increases γ-Tocotrienol Oral Bioavailability. Lipids. 2012 [Epub ahead of print] Ayoub N, Lucas C, Kaddoumi A. Genomics and pharmacogenomics of breast cancer: current knowledge and trends. Asian Pac J Cancer Prev. 2011; 12(5):1127-40 Abuznait AH, Qosa H, O'Connell ND, Akbarian-Tefaghi J, Sylvester PW, El Sayed KA, Kaddoumi A. Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products. Food Chem Toxicol. 2011 Nov; 49(11):2765-72 Abuznait AH, Patrick SG, Kaddoumi A. Exposure of LS-180 cells to drugs of diverse physicochemical and therapeutic properties up-regulates P-glycoprotein expression and activity. J Pharm Pharm Sci. 2011;14(2):236-48