个人简介

Doug E. Frantz was born in Kettering, OH in 1971. He obtained his B.S. in Chemistry in 1994 at Stephen F. Austin State University in Nacogdoches, Texas under the guidance of Dr. James Garrett. In 1998, he received his Ph.D. degree in organic chemistry at Texas A&M University in College Station, TX under the supervision of Dan Dr. Singleton where he worked on the synthetic and mechanistic studies of carbometalations reactions. He then moved on to do a post-doctoral fellowship with Dr. Erick Carreira at the ETH – Zürich in Zürich, Switzerland where he discovered and developed the asymmetric addition of zinc acetylides to aldehydes. He then joined the Department of Process Research at Merck & Co., Inc. in 2000 in Rahway, NJ where he worked on the development of practical and efficient syntheses to various drug candidates in Merck’s pipeline. In late 2001, he moved to a new Merck site in Wayne, PA where he continued to work in the area of pre-clinical drug development and process chemistry. With a desire to return back to Texas, late in 2005 Dr. Frantz joined the faculty in the Department of Biochemistry at the University of Texas Southwestern Medical Center at Dallas as a research assistant professor and Director of the Synthetic Chemistry Core Facility. He is currently an Assistant Professor of Chemistry at the University of Texas at San Antonio, San Antonio, TX.

研究领域

Asymmetricatalysi ;Heterocyclisynthesi ;Medicinachemistr ;Physicaorganichemistr ;Proceschemistry

The centralized theme of research in my lab involves the application and development of new synthetic methodology in organic chemistry that can provide new avenues of chemical reactivity while keeping practicality as a viable and equally important goal. Many of the reactions we develop are mediated by late-transition metals catalysts that are fine-tuned through the use of real-time quantitative techniques allowing us to rapidly screen new reactions and parameters with unparalleled efficiency in academia. Furthermore, my lab is also involved with several medicinal chemistry programs aimed at developing new small molecule probes towards studying the mechanisms of stem cell differentiation. Students in my lab learn techniques in synthetic chemistry, medicinal chemistry, analytical chemistry, physical organic chemistry and drug discovery and development.

近期论文

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Crouch, I.T.; Neff, R.K.; Frantz, D.E. "Pd-Catalyzed Asymmetric Beta-Hydride Elimination En Route to Chiral Allenes" J. Am. Chem. Soc. 2013, 135 (13), 4970–4973. Scheuermann, T.H.; Li, Q.; Ma, H.–W.; Key, J.; Zhang, L.; Chen, R.; Garcia, J.A.; Naidoo, J.; Longgood, J.; Frantz, D.E.; Tambar, U.K.; Gardner, K.H.; Bruick, R.K. "Allosteric Inhibition of Hypoxia Inducible Factor 2 with Small Molecules" Nature Chem. Bio., 2013, 9, 271–276. Rogers, J.L.; Bayeh, L.; Scheuermann, T.H.; Longgood, J.; Caldwell, C.; Key, J.; Naidoo, J.; Melito, L.; Shokri, C.; Frantz, D.E.; Bruick, R.K.; Gardner, K.H.; MacMillan, J.B.; Tambar, U.K. "Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor" J. Med. Chem., 2013, 56(4), 1739–1747. Babinksi, D.J.; Bao, X.; El Arba, M.; Chen, B.; Hrovat, D.A.; Borden, W.T.; Frantz, D.E. "Synchronized Aromaticity as an Enthalpic Driving Force for the Aromatic Cope Rearrangement" J. Am. Chem. Soc., 2012, 134, 16139. Kato, M.; Han, T.W.; Xie, S.; Shi, K.; Du, X.; Wu, L.C.; Mirzaei, H.; Goldsmith, E.J.; Longggood, J.; Pei, J.; Grishin, N.V.; Frantz, D.E.; Schneider, J.W.; Chen, S.; Li, L.; Sawaya, M.R.; Eisenberg, D.; Tycko, R.; McKnight, S.L. "Cell-free formation of RNA granules: Low complexity sequence domains form dynamic fibers within hydrogels" Cell, 2012, 149, 753-767. Zang, Q.S.; Hesham, S.; Maass, D.L.; Martinez, B.; Ma, L.; Kilgore, J.A.; Williams, N.S.; Frantz, D.E.; Wigginton, J.G.; Nwariaku, F.E.; Wolf, S.E.; Minei, J.P. "Specific Inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model" American Journal of Physiology-Heart and Circulatory Physiology, 2012, 302, H1847-H1859 Russell, J.L.; Goetsch, S.C.; Aguilar, H.R.; Coe, H.; Luo, X.; Liu, N.; van Rooij, E.; Frantz, D.E.; Schneider, J.W. "Targeting Native Adult Heart Progenitors with Cardiogenic Small Molecules" ACS Chemical Biology, 2012, 7, 1067. Russell, J.L.; Goetsch, S.C.; Aguilar, H.R.; Frantz, D.E.; Schneider, J.W. "Regulated expression of pH sensing G protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease" ACS Chemical Biology, 2012 7, 1077. Hartley, R.M.; Peng, J.; Fest, G.A.; Dakshanamurthy, S.; Frantz, D.E.; Brown, M.L.; Mooberry, S.L. "Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site" Mol. Pharm., 2012, 81, 431. Mata, M.A.; Satterly, N.; Versteeg, G.A.; Frantz, D.E.; Wei, S.; Williams, N.; Schmolke, M.; Peña-Llopis, S.; Brugarolas, J.; Forst, C.V.; White, M.A.; Garcia-Sastre, A.; Roth, M.G.; Fontoura, B.M.A. "Chemical inhibition of RNA viruses reveals REDD1 as a host defense fact" Nature Chem. Bio., 2011, 7, 712-719. Babinski, D.J.; Aguilar, H.A.; Still, R.; Frantz, D.E. "Synthesis of substituted pyrazoles via tandem cross-coupling/electrocyclization of enol triflates and diazoacetates" J. Org. Chem., 2011, 5915. (Featured Article and Highlighted by SYNFACTS Crouch, I.T.; Dreier, T.; Frantz, D.E. "Palladium-catalyzed elimination/isomerization of enol triflates into 1,3-dienes" Angew. Chem. Int. Ed., 2011, 6128-6132. (Highlighted by SYNFACTS) Wang, Y.X.; Zang, Q.S.; Liu, Z.J.; Wu, Q.; Maass, D.; Dulan, G.; Shaul, P.W.; Melito, L.; Frantz, D.E.; Kilgore, J.A.; Williams, N.S.; Terada, L.S.; Nwariaku, F.E. "Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species" Am. J. Phys. Cell Phys., 2011, 301, C695-C704. Zhang, L.; Peng, L.; Hsu, T.; Aguilar, H.R.; Frantz, D.E.; Schneider, J.W.; Bachoo, R.M.; Hsieh, J. "Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression" Differentiation, 2011, 81, 233-242. Peng, J.; Jackson, E.M.; Babinski, D.J.; Risinger, A.L.; Helms, G.; Frantz, D.E.; Mooberry, S.L. "Evelynin, a ctyotoxic benzoquinone-type retro-dihydrochalcone from Tacca chantrieri" J. Nat. Prod., 2010, 73,1590. Menzel, K.; Machrouchi, F.; Bodenstein, M.; Alorati, A.; Cowden, C.; Gibson, A.W.; Bishop, B.; Ikemoto, N.; Nelson, T.D.; Kress, M.H.; Frantz, D.E. "Process development of a potent bradykinin 1 antagonist" Org. Process Res. Dev., 2009, 13, 519. Lee, J.; Sperandio, V.; Frantz, D.E.; Longgood, J.; Camilli, A.; Phillips, M.A.; Michael, A.J. "An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae" J. Biol. Chem., 2009, 284, 9899. Schneider, J.W.; Gao, Z.; Li, S.; Farooqi, M.; Tang, T.-S.; Bezprozvanny, I.; Frantz, D.E.; Hsieh, J. "Small-molecule activation of neuronal cell fate" Nature Chem. Bio., 2008, 4, 408. Babinski, D.; Soltani, O.; Frantz, D.E. "Stereoselective synthesis of acetoacetate-derived enol triflates" Org. Lett., 2008, 10, 2901. Sadek, H.; Hannack, B.; Choe, E.; Wang, J.; Latif, S.; Garry, M.G.; Garry, D.J.; Longgood, J.; Frantz, D.E.; Olson, E.N.; Hsieh, J.; Schneider, J. W. "Cardiogenic small molecules that enhance myocardial repair by stem cells" Proc. Natl. Acad. Sci. U.S.A., 2008, 105, 6063-6068.