Marletta, Michael - The Scripps Research Institute

研究领域

Marletta's primary research interests lie at the interface of chemistry and biology with emphasis on the study of protein function and enzyme reaction mechanisms. Marletta has made fundamental discoveries concerning the biological action of nitric oxide. His studies have provided the basis for understanding at the molecular level of this unique cell signaling pathway and the function of nitric oxide in the immune system. He has uncovered several novel structure/function relationships in nitric oxide synthase and guanylate cyclase. His continued studies on NO signaling have recently led to a molecular understanding of general gas sensing mechanisms in biology.

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Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Herzik MA Jr, Jonnalagadda R, Kuriyan J, Marletta MA. Proc Natl Acad Sci USA. 2014, 111, E4156-64. A family of starch-active polysaccharide monooxygenases. Vu VV, Beeson WT, Span EA, Farquhar ER, Marletta MA. Proc Natl Acad Sci USA. 2014, 111, 13822-7. Molecular architecture of mammalian nitric oxide synthases. Campbell MG, Smith BC, Potter CS, Carragher B, Marletta MA. Proc Natl Acad Sci USA. 2014, 111, E3614-23. Nitric oxide-induced conformational changes in soluble guanylate cyclase. Underbakke ES, Iavarone AT, Chalmers MJ, Pascal BD, Novick S, Griffin PR, Marletta MA. Structure. 2014, 22, 602-11. Direct meso-alkynylation of metalloporphyrins through gold catalysis for hemoprotein engineering. Nierth A, Marletta MA. Angew Chem Int Ed Engl. 2014, 53, 2611-4. Single-particle EM reveals the higher-order domain architecture of soluble guanylate cyclase. Campbell MG, Underbakke ES, Potter CS, Carragher B, Marletta MA. Proc Natl Acad Sci USA. 2014, 111, 2960-5. Determinants of regioselective hydroxylation in the fungal polysaccharide monooxygenases. Vu VV, Beeson WT, Phillips CM, Cate JH, Marletta MA. J Am Chem Soc. 2014, 136, 562-5. Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network. Plate L, Marletta MA. Proc Natl Acad Sci USA. 2013, 26, E4648-57. Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior. Plate L, Marletta MA. Trends Biochem Sci. 2013, 38, 566-75. Weinert EE, Phillips-Piro CM, Marletta MA. Porphyrin π-stacking in a heme protein scaffold tunes gas ligand affinity. J Inorg Biochem. 2013, 127, 7-12. Smith, BC, Underbakke ES, Kulp DW, Schief WR, Marletta MA. Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation. Proc Natl Acad Sci USA. 2013, 110, E3577-E3586. Underbakke ES, Iavarone AT, Marletta MA. Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase. Proc Natl Acad Sci USA. 2013, 110, 6777-6782. Fernhoff NB, Derbyshire ER, Underbakke ES, Marletta MA. Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. J Biol Chem. 2012, 287, 43053-62. Smith BC, Marletta MA. Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling. Curr Opin Chem Biol. 2012, 16, 498-506. Li X, Beeson WT 4th, Phillips CM, Marletta MA, Cate JH. Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases. Structure. 2012, 20, 1051-61. Plate L, Marletta MA. Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network. Mol. Cell. 2012 46:449-60. Gunn A, Derbyshire ER, Marletta MA, Britt RD. Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). Biochemsitry. 2012, 51, 8384-90. Surmeli NB, Marletta MA. Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat. Chembiochem. 2012, 13(7):977-81. Derbyshire ER, Marletta MA. Structure and regulation of soluble guanylate cyclase. Annu Rev Biochem. 2012, [Epub ahead of print]. Smith BC, Fernhoff NB, Marletta MA. Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation. Biochemistry. 2012, 51(5):1028-40.