Brinsmade, Shaun - Georgetown College

个人简介

NIH Postdoctoral Fellow (2008-2013) Tufts University School of Medicine, Metabolism and Virulence in Gram-positive bacteria Ph.D. (2007) University of Wisconsin-Madison, Microbiology B.S. (2001) University of Connecticut-Storrs, Molecular and Cell Biology

研究领域

Bacterial pathogenesis; nutrient sensing

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Waters NR, Samuels DJ, Behera RK, Livny J, Rhee KY, Sadykov MR, Brinsmade SR. "A Spectrum of CodY Activities Drives Metabolic Reorganization and Virulence Gene Expression in Staphylococcus aureus.." Mol Microbiol. 101.3 (2016): 495-514. Belitsky BR, Brinsmade SR, Sonenshein AL. "Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB.." PLoS Genet. 11.10 (2015): e1005600. Sassi M, Sharma D, Brinsmade SR, Felden B, Augagneur Y.. "Genome Sequence of the Clinical Isolate Staphylococcus aureus subsp. aureus Strain UAMS-1.." Genome Announc. 3.1 (2015): e01584-14. Kriel A, Brinsmade SR, Tse JL, Tehranchi AK, Bittner AN, Sonenshein AL, Wang JD. "GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes.." J Bacteriol. 196.1 (2014): 189-201. Brinsmade SR, Alexander EL, Livny J, Stettner AI, Segrè D, Rhee KY, Sonenshein AL. "Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY.." Proc Natl Acad Sci U S A. (2014). Brinsmade SR, Sonenshein AL. "Dissecting complex metabolic integration provides direct genetic evidence for CodY activation by guanine nucleotides.." J Bacteriol. 193 (2011): 5637-5648. Lima BP, Antelmann H, Gronau K, Chi BK, Becher D, Brinsmade SR, Wolfe AJ. "Involvement of protein acetylation in glucose-induced transcription of a stress-responsive promoter.." Mol Microbiol. 81 (2011): 1190-1204. Brinsmade SR, Kleijn RJ, Sauer U, Sonenshein AL. "Regulation of CodY activity through modulation of intracellular branched-chain amino acid pools.." J Bacteriol. 192 (2010): 6357-6368. Brinsmade SR, Escalante-Semerena JC. "In vivo and in vitro analyses of single-amino acid variants of the Salmonella enterica phosphotransacetylase enzyme provide insights into the function of its N-terminal domain.." J Biol Chem. 282 (2007): 12629-12640. Kim YR, Brinsmade SR, Yang Z, Escalante-Semerena J, Fierer J. "Mutation of phosphotransacetylase but not isocitrate lyase reduces the virulence of Salmonella enterica serovar Typhimurium in mice.." Infect Immun. 74 (2006): 2498-2502. Brinsmade SR, Paldon T, Escalante-Semerena JC. "Minimal functions and physiological conditions required for growth of salmonella enterica on ethanolamine in the absence of the metabolosome.." J Bacteriol. 187 (2005): 8039-8046. Brinsmade SR, Escalante-Semerena JC. "The eutD gene of Salmonella enterica encodes a protein with phosphotransacetylase enzyme activity.." J Bacteriol. 186 (2004): 1890-1892. Silvaggi NR, Anderson JW, Brinsmade SR, Pratt RF, Kelly JA. "The crystal structure of phosphonate-inhibited D-Ala-D-Ala peptidase reveals an analogue of a tetrahedral transition state.." Biochemistry. 42 (2003): 1199-1208.