个人简介
UT Arlington College of Science Outstanding Research Award (Faculty) (2013)
FEBS Journal Top-Cited Paper Award (2012)
FEBS Journal Top (10) cited paper award (2011)
Faculty Fellow for Service Learning, UT Arlington (2009)
College of Science Research Excellence Award, UT Arlington (2008)
Howard Hughes Medical Institute (HHMI) Postdoctoral Fellow (2003)
Alberta Heritage Foundation for Medical Research Postdoctoral Fellow, Canada (1999)
Guha Research Gold Medal for the best PhD thesis, Indian Institute of Science (1998)
Indo-Hungarian Research Fellow, Hungary (1997)
CSIR Junior and Senior Research Fellowship, India (1992)
GATE-92,99.29 percentile, 5th position in India (1992)
B.Sc. (Honors in Chemistry) Midnapore College, India (1989)
M.Sc. (First Class First) Kalyani University, India (1992)
Ph.D. Indian Institute of Science (Laboratory of Santanu Bhattacharya, 1998)
Postdoctoral Fellow:
University of Alberta (Laboratory of Linda J Reha-Krantz, 1998-99)
Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey (Laboraotry of Danny Reinberg, 2000-2005)
Subhrangsu Mandal is an Associate Professor at the Deartment of Chemistry and Biochemistry, University of Texas at Arlington. He rceived his Bachelor's and Master's degrees (with first class first) in Chemistry from Midnapore College and Kalyani University. He received his PhD degree in 1998 from the Indian Institute of Science, Bangalore, where he worked on DNA damaging agents and cationic liposome-mediated gene delivery under the supervision of Professor S. Bhattacharya. He joined the laboratory of Professor L. J. Reha-Krantz as an Alberta Heritage Foundation for Medical Research (AHFMR) postdoctoral fellow at the University of Alberta, Canada. He later moved to the laboratory of Professor Danny Reinberg to research on eukaryotic transcription and gene regulation in human at the University of Medicine and Dentistry of New Jersey (UMDNJ)/Howard Hughes Medical Institute (HHMI). In 2005, he became an Assistant Professor in UTA.
Dr. Mandal is an expert in the field of biochemistry of human gene regulation, epigenetics and disease. His current research is aimed towards understanding the fundamentals of human gene transcription and steroid hormone signaling associated with cardiovascular diseases and cancer. He has published more than 60 publications in top international journals, written multiple invited review articles, applied several patents and presented seminars in various conferences and universities around the world. Research from his laboratory is featured on the cover page of FEBS Journal. Dr. Mandal's research is funded by National Institute of Health, American Heart Association, Texas Advanced Research Program and National Science Foundation. In parallel to research, Dr. Mandal enjoys teaching biochemistry and interacting with students in the university campus. In leisure time, Dr. Mandal loves gardening, trekking, photography, playing music (Sitar), soccer and spending time with his family.
研究领域
We are interested in understanding the biochemical and epigenetic mechanism of gene expression and epigenetics in human cells and in various human disease including cancer. Specifically, we are investigating the functions of Mixed Lineage Leukemia (MLL) family of histone methyl-transferases in gene activation, steroid hormone signaling, and cancer. MLLs are key players in hematpoietic stem cell differentiation, childhood myeloid and lymphoid leukemias and other types of cancers. Studies from my laboratory demonstrate that MLLs are critical players in Hox gene expression, cell cycle progression, hypoxia signaling, angiogenesis, and in tumor growth. Inhibition of MLL suppresses tumor growth in vivo (mice model). MLLs act as novel coactivators for nuclear hormone receptors that are closely associated with breast and prostate cancers. Major research areas are as follows.
Human Gene Regulation and Epigenetics: Functions of MLL histone methylases in Hox gene expression and cell cycle regulation.
Hypoxia Signaling, Angiogenesis and Cancer Biology: We are investigatting the tumor microenvironment especially the hypoxia signaling, angiogenesis and their impacts on tumor growth, chemosensivity and therapy.
Steroid Hormone Signaling and Molecular Endocrinology: MLL histone methylases in estrogen signaling, blood cholesterol and cancer.
Endocrine Disrupting Chemicals (EDC): Identification, risk assessment and epigenetic mechanism.
Gene Therapy: Develop novel targeted gene therapy (cell culture and mice model).
Drug Development: Screen small molecules, metal-complexes in apoptosis and hormonal assays (cell culture and mice model).
近期论文
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Mandal SS.*, Ansari K.I., and Grant J.D., Anti-tumor and apoptosis activities of metallo-salens, United States Patent, Number 8198322, Issued June 2012.
Recent Trends in Gene Expression” Editor: Subhrangsu S. Mandal (Nova Science Publishers), ISBN-13: 9781626186804, Available in hard copies and online 2013
Bhan A. and Mandal SS.* Long non-coding RNAs: Emerging stars in gene regulation, epigenetics and human disease, ChemMedChem, 2014, In press, Invited Review
Mandal SS, “Recent Trends in Gene Expression” An Editorial in book “Gene Expression”, 2013, edited by Nova Publishers.
Mandal SS*, Ansari KI., Hussain I. and Bhan A. Impacts of deoxynivalenol (DON) on Human cells: Oxidative Stress, Misregulation of Histone Modifying enzymes, HOX genes, and Epigenetics. Mycotoxins: Properties, Applications and Hazards, 2011. (Book Chapter, Edited by Nova Science Publishers ISBN: 978-1-62100-644-2).
Mandal SS* Metallo-salen complexes show promise towards treatment of leukemia. An editorial Leukemia Research 2011, 35, 571-572.
Mandal SS*, Mixed lineage leukemias: Versatile players in gene expression, hormone signaling and diseases, FEBS J 2010, 277, 1789-1789. Preface to the mini-review series. Dr. Mandal is the organizer of this invited mini-review series (MRS) on “Mixed lineage leukemia”.
Ansari KI and Mandal SS.*, Mixed Lineage Leukemia: roles in gene expression, hormone signaling and mRNA processing, FEBS Journal 2010, 277, 1790-1804. Review. Received FEBS Journal Top-cited paper award in 2012.
Ansari K.I., Mishra, B.M. and Mandal S.S*, MLL histone methylases in gene expression, hormone signaling and cell cycle, Frontiers in Biosciences 2009, 14, 3483-95, Review.
Sims RJa., Mandal SSa., and Reinberg D. “Recent highlights in RNAP II mediated transcription”, Current Opinion in Cell Biology 2004, 16, 263-71, Review. aContributed equally.
PhD thesis work is included in “Advanced Inorganic Chemistry” by F.A. Cotton, G Wilkinson, C.A. Murilo and M. Bochmann, 6th Edition, A Wiley inter science publication, 1999, page 828.
Bhan A. and Mandal SS.* Long non-coding RNAs: Emerging stars in gene regulation, epigenetics and human disease, ChemMedChem, 2014, In press, Invited Review
Bhan A, Hussain I., Ansari KI, Bobzean SM., Perrotti L., and Mandal SS.* Bisphenol A and diethylstilbestrol exposure induces breast cancer associated long non-coding RNA HOTAIR expression in vitro and in vivo, Journal of Steroid Biochemistry and Molecular Biology, 2014, in press
Das J., Bhan A., Mandal S.S. and Lovely C.J. Total syntheses and cytotoxicity of kealiiquinone, 2-deoxykealiiquinone and analogs, Bioorganic and Medicinal Chemistry Letters, 2013, 23, 6183-7.
Bhan A., Ansari KI., Kasiri S., Hussain I., Bashyal A., and Mandal SS* “ Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally regulated by estradiol. Journal of Molecular Biology, 2013, 2013, 425(19):3707-22, Special issue on non-coding RNA.
Kasiri S., Ansari K., Hussain I., and Mandal SS*. “Antisense oligonucleotide mediated knockdown of HOXC13 affects cell growth and induces apoptosis in tumor cells and over expression of HOXC13 induces 3D-colony formation” RSC Advances, 2013, 3(10): 3260-3269. Invited manuscript in honor of Professor H.G. Khorana.
Mandal SS, “Recent Trends in Gene Expression” An Editorial in book Gene Expression, 2013, edited by Nova Publishers.
Ansari KI, Kasiri S, Hussain I, Bobzean S, Perrotti L, and Mandal SS*,MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo, Molecular Endocrinology 2013 27, 92-105.
Ansari KI, Kasiri S., and Mandal SS.* Histone Methylase MLL1 plays critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo, Oncogene 2013, 32(28):3359-70. (Nature Press).
Shrestha B, Ansari KI., Bhan A., Kasiri S., Hussain I., and Mandal SS*., Homeodomain containing protein HOXB9 regulates expression of growth and angiogenic factors, facilitates tumor growth in vitro and is overexpressed in breast cancer tissue., FEBS Journal 2012, 279, 3315-26.
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