袁久洪 - 四川大学 - 生物治疗国家重点实验室

个人简介

1983-1989毕业于华西医科大学；1988-2000在北京协和医院泌尿外科工作；2000-2010在美国德州大学安德森癌症中心从事博士后和科研工作；于2010年起作为一层次人才被引进到华西医院工作至今。现任华西医院科技平台部负责人。获国家自然科学基金面上项目3项、省科技厅支撑项目2项，总纵向经费200多万元。研究成果主要发表于European Urology，Journal of Sexual Medicine, Cancer Research，Clinical Cancer Research等国际著名学术期刊。并获准专利多项。

研究领域

(1) 肿瘤表观遗传学;(2) 泌尿系统疾病的生物治疗；(3) 药理学。

近期论文

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(1) Lin H, Yuan J, Ruan KH, Yang W, Zhang J, Dai Y, Wang R. COX-2-10aa-PGIS Gene Therapy Improves Erectile Function in Rats after Cavernous Nerve Injury. J Sex Med. 2013;10(6):1476-87. (2) Qin F, Liu JY, Yuan JH*. Chaihu-Shugan-San, an oriental herbal preparation, for the treatment of chronic gastritis: A meta-analysis of randomized controlled trials. J Ethnopharmacol 2013; 146(2): 433-439. (3) Dong Q, Deng S, Wang R, Yuan JH*.In vitro and in vivo animal models in priapism research. J Sex Med 2011;8:347-59. (IF: 3.957 ) (4) Yuan JH, Lin H, Li P, Zhang R, Luo A, Berardinelli F, Dai Y, Wang R. Molecular Mechanisms of Vacuum Therapy in Penile Rehabilitation: A Novel Animal Study. Eur Urol 2010;58:773-80. (IF: 8.843) (5) Yuan JH, Hoang AN, Romero C, Lin HC, Dai YT, Wang R. Vacuum Therapy in Erectile Dysfunction – Science and Clinical Evidence. Int J Impot Res 2010; 4: 211-19. (6) Yuan JH, Westney OL, Wang R. Design and Application of a New Rat-Specific Vacuum Erectile Device for Penile Rehabilitation Research. J Sex Med 2009;6:3247-53. (IF: 5.393) (7) Yuan JH, Westney OL, Ruan KH, Wang R. A new strategy, SuperEnzyme gene therapy in penile rehabilitation. J Sex Med 2009; 6:328-33 (IF: 5.393) (8) Yuan JH, Luo RZ, Fujii S, Wang L, Hu W. Aberrant methylation and Silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancer. Cancer Res 2003; 63:4174-80. (IF: 8.318) (9) Fujii S, Luo RZ, Yuan JH, Kadota M, Oshimura M, Dent SR, Kondo Y, Issa JP, Bast RC Jr, Yu Y. Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. Hum Mol Genet 2003;12:1791-800. (10) Wang L., Hoque A, Luo RZ, Yuan JH, Lu Z, Nishimoto A, Liu J, Sahin AA, Lippman SM, Bast RC Jr, Yu Y. Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer. Clin Cancer Res 2003;9: 3660-6.