吴晓华 - 四川大学 - 生物治疗国家重点实验室

个人简介

1993 年毕业于泸州医学院，获医学学士学位， 2002 年考入日本京都大学医学院分子医学专业攻读博士学位， 2006 年毕业获医学博士学位，同年作为国家 “ 985 ”引进人才回国，工作于四川大学生物治疗国家重点实验室，从事天然药物、小分子化合物的抗炎、抗肿瘤药物研发和肿瘤靶向治疗研究工作.作为项目负责人承担国家“ 863” 计划专项子课题“ （ 2007 AA021810 ）肝癌细胞靶向的长循环纳米脂质体研发 ”； “ 十一五”“重大新药创制”科技重大专项课题“（ 2009ZX09102-045 ）新型 PI3Kγ 抑制剂治疗急性重症肝炎一类新药临床前研究” ；教育部留学回国人员科研启动基金课题“ （ JS20081007506765 ）自身免疫性疾病的分子靶向研究”

研究领域

细胞生物学研究；疾病的免疫调节及免疫治疗研究；抗炎和抗肿瘤药物开发研究

近期论文

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Xiaohua Wu ,Katsuya Takenaka, Eiichiro Sonoda, Helfrid Hochegger, Shosuke Kawanishi, Takuo Kawamoto, Shunichi Takeda. Critical roles for polymerase {zeta}in cellular tolerance to nitric oxide?Cinduced DNA damage. Cancer Res 2006;66(2):748?C754. Wu X , Takenaka K, Sonoda E, etal. Frontiers in Cancer Prevention Research.October30 -Nonember2, 2005 Baltimore,MD USA. Wu X , Takenaka K, Sonoda E, etal. The 5th International 3R (replication, recombination,repair) Symposium.November13-17, 2005,Awaji,Japan Wang ZL , Wu XH , Song LF , Wang YS , Hu XH , Luo YF , Chen ZZ Ke J , Peng XD , He CM , Zhang W , Chen LJ , Wei YQ . Phosphoinositide 3-kinase gamma inhibitor ameliorates concanavalin A-induced hepatic injury in mice. Biochem Biophys Res Commun. 2009 Sep 4;386(4):569-74. ） Li ZG , Zhao YL , Wu X H , Ye HY , Peng A , Cao ZX , Mao YQ , Zheng YZ , Jiang PD , Zhao X , Chen LJ , Wei YQ . Barbigerone, a natural isoflavone, induces apoptosis in murine lung-cancer cells via the mitochondrial apoptotic pathway. Cell Physiol Biochem. 2009; 24(1-2):95-104. Xiaodong Peng, Xiaohua Wu , Lijuan Chen, Yuquan Wei, etal. Protective and Therapeutic Potentials of Phosphoinositide 3-kinase γ Inhibitor in Experimental Murine Colitis. Journal of Pharmacology and Experimental Therapeutics. 2009 Oct 14 ; Yuan Qin; Xiaohua Wu; Wen Huang; Guohua Gong; Dan Li; Yang He; Yinlan Zhao. Acute toxicity and sub-chronic toxicity on liver of steroidal saponins from Dioscorea Zingiberensisin C.H.Wright in rodents. Journal of Ethnopharmacology. 2009;126(3): 543-550. Gong, Guohua; Qin, Yuan; Wu, Xiaohua; Huang, Wen; etal. Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis. European Journal of Pharmacology . In Press, Available online 19 November . Jin K , Song LF , He CM , Wang ZL , Hu XH , Wu XH . Intervention effect of PI3Kgamma inhibitor AS605240 on autoimmune myocarditis in mice. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Sep;40(5):817-20, 825