王修杰 - 四川大学 - 生物治疗国家重点实验室

个人简介

1985.9-1988.6 华西医科大学医学院肿瘤学专业硕士研究生，获硕士学位。 1990.2-1996.5 华西医科大学院肿瘤研究所任助理研究员 1996.6-2001.6 华西医科大学院肿瘤研究所任副研究员 1998.3-1999.3 日本国东京大学医学院分子病理研究室高访研修 2001.2- 至今四川大学华西临床医学院 / 医院实验肿瘤研究室、老年医学研究室任教授 2001.9-2004.6 四川大学华西临床医学院在职博士研究生，获肿瘤学博士学位

研究领域

1 肿瘤干细胞生物学分离、鉴定实体瘤的肿瘤干细胞，建立肿瘤干细胞的体内、外实验模型，研究肿瘤干细胞与其相应的肿瘤细胞、正常干细胞生物学特性的异同，以期探索靶向肿瘤干细胞的根治措施。 2 老化与肿瘤建立老化与肿瘤的动物模型，尤其是大动物模型，研究老化、肿瘤的病因学因素及发生机理，老化与肿瘤的关系及防治基础。 3 抗氧化、抗衰老、抗肿瘤新药及作用机理利用老化与肿瘤的动物模型，结合现有工作基础，研究抗氧化、抗衰老、抗肿瘤新药及作用机理

近期论文

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1. Zhang QB Gao YP, He JT, Zhang TT, Lin P, Zhang J, Wang XJ * . Establishment of a novel human esophageal squamous cell carcinoma cell line (ESC-410) and its partial biological characterization . Dis Esophagus. published online 2 SEP 2010 2. Wang J , Wang X * , Jiang S , Lin P , Zhang J , Wu Y , Xiong Z , Ren JJ , Yang H . Partial biological characterization of cancer stem-like cell Line (WJ 2 ) of human glioblastoma multiforme. Cell Mol Neurobiol. 2008 ;28(7):991-1003. 3. Liu JM , Mao BY , Hong S , Liu YH , Wang XJ * . The postoperative brain tumour stem cell (BTSC) niche and cancer recurrence . Adv Ther. 2008;25(5):389-98 . 4. Wang J, Wang X * , Jiang S, Lin P, Zhang J, Lu Y, Wang Q, Xiong Z, Wu Y, Ren J, Yang H. Cytotoxicity of fig fruit latex against human cancer cells. Food Chem Toxicol. 2008 ； 46 ： 1025-1033. 5. Wang J, Wang X * , Jiang S, Lin P, Zhang J, Wu Y, Xiong Z, Ren JJ, Yang H. Establishment of a New Human Glioblastoma Multiforme Cell Line (WJ1) and Its Partial Characterization. Cell Mol Neurobiol. 2007; 27(7): 831-843. 6. Wang J, Wang X * , Jiang S, Yuan S, Lin P, Zhang J, Lu Y, Wang Q, Xiong Z, Wu Y, Ren J, Yang H. Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J Neurooncol. 2007; 82 (1): 11-21. 7. Wang X * , Wei Y, Yuan S, Liu G, Zhang J, Wang W. Potential anticancer activity of litchi fruit pericarp extract against hepatocellular carcinoma in vitro and in vivo. Cancer Lett. 2006; 239(1): 144-150. 8. Wang X * , Yuan S, Wang J, Lin P, Liu G, Lu Y, Zhang J, Wang W, Wei Y. Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo. Toxicol Appl Pharmacol. 2006; 215(2): 168-178. 9. Wang X * , Wei Y, Yuan S, Liu G, Lu Y, Zhang J, Wang W. Potential anticancer activity of tanshinone IIA against human breast cancer . Int J Cancer. 2005; 116 (5): 799-807. 10. Wang XJ * , Yuan SL , Lu Q , Lu YR , Zhang J , Liu Y , Wang WD . Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma. World J Gastroenterol. 2004; 10(17):2478-2481. 11. Wang XJ * , Yuan SL , Li CP , Iida N , Oda H , Aiso S , Ishikawa T .Infrequent p53 gene mutation and expression in the cardia adenocarcinomas from a high-incidence area of Southwest China. World J Gastroenterol ,2000;6(5):750-753. 12. Wang X , Xu C , Wang X , Wang D , Wang Q , Zhang B . Heat shock response and mammal adaptation to high elevation (hypoxia). Sci China C Life Sci . 2006 ;49(5):500-512. 13. Lu YR , Yuan Y , Wang X , Wei LL , Chen YN , Cong C , Li SF , Long D , Tan WD , Mao YQ , Zhang J , Li YP , Cheng JQ . The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo. Cancer Biol Ther. 2008; 7(2):245-251 .