苏智广 - 四川大学 - 生物治疗国家重点实验室

个人简介

2001年在四川大学华西临床医学院获医学遗传学博士学位，并留院工作。2005年1月~ 2009年7月在美国弗吉尼亚大学（University of Virginia）和The Jackson Laboratory博士后研究工作。2013年任副研究员/副教授， 2019年任研究员/教授。近年来，以第一或通讯作者在国际专业杂志发表SCI收录学术论文30余篇。担任Physiological Genomics, Int J Obesity, Acta Pharmacologica Sinica等杂志特邀审稿人。获准863项目、国家自然科学基金、教育部资助科研项目。以负责人完成的项目“冠状动脉硬化和肥胖症脂代谢的遗传基础与临床研究”获得2010年四川省科技进步二等奖。

研究领域

（1）肥胖及糖尿病治疗药物筛选及作用机制：应用脂肪细胞及动物模型（高脂饲料诱导的或基因敲除小鼠）筛选调节脂肪细胞分化、葡萄糖生成、胰岛功能和影响肥胖、糖尿病发生等的化合物，并应用基因表达组学、高通量基因测序技术、基因功能研究等策略阐明药物作用机制。（2）肥胖与代谢分子调控：研究肥胖成因及肥胖所导致的代谢紊乱的分子机制。（3）复杂疾病候选致病基因筛查：通过基因组测序发现基因变异或突变，研究其与疾病相关性，并进行功能研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhang Y, Guan Q, Liu Y, Zhang Y, Chen Y, Chen J, Liu Y, Su Z (通讯作者). Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice. J Biol Chem. 2018; 293(20):7894-7904. 2. Liu Y, Chen Y, Zhang J, Liu Y, Zhang Y, Su Z (通讯作者). Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress. J Biol Chem. 2017; 292(34):13959-13969. 3. Liu Y, Zhang Y, Zhang Y, Zhang J, Liu Y, Feng P, Su Z (通讯作者). Obesity-induced endoplasmic reticulum stress suppresses nuclear factor-Y expression. Mol Cell Biochem. 2017; 426(1-2):47-54. 4. Yuan YM, Zhang JL, Xu SC, Ye RS, Xu D, Zhang Y, Zhang YJ, Chen YL, Liu YL, Su ZG (通讯作者). Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population. Acta Pharmacol Sin. 2016; 37(3):390-7. 5. Chen Y, Su Z (通讯作者). Reveal genes functionally associated with ACADS by a network study. Gene. 2015, 569(2):294-302 6. Shi K, Wang X, Zhu J, Cao G, Zhang K, Su Z (通讯作者). Salidroside protects retinal endothelial cells against hydrogen peroxide-induced injury via modulating oxidative status and apoptosis. Biosci Biotechnol Biochem. 2015; 79(9):1406-13. 7. Cao G, Chen Y, Zhang J, Liu Y, Zhang M, Zhang K, Su Z (通讯作者). Effects of adiponectin polymorphisms on the risk of advanced age-related macular degeneration. Biomarkers. 2015; 20(4):266-70. 8. Yuan Y, Hou X, Zhang J, Chen Y, Feng Y, Su Z (通讯作者). Genetic variations in RORα are associated with chronic obstructive pulmonary disease. J Hum Genet. 2014;59(8):430-6. 9. Kuang J, Hou X, Zhang J, Chen Y, Su Z (通讯作者). Identification of insulin as a novel retinoic acid receptor-related orphan receptor α target gene. FEBS Lett. 2014; 588(6):1071-9. 10. Zhou J, Wang D, Zhang J, Zhang M, Li G, Zhang K, Zhang M, Su Z (通讯作者). RAD51 gene is associated with advanced age-related macular degeneration in Chinese population. Clin Biochem. 2013; 46(16-17):1689-93. 11. Yuan Y, Jiang H, Kuang J, Hou X, Feng Y, Su Z (通讯作者). Genetic Variations in ADIPOQ Gene Are Associated with Chronic Obstructive Pulmonary Disease. PLoS One. 2012; 7(11):e50848. doi: 10.1371 12. Xu S, Kuang J, Liu J, Ma C, Feng Y, Su Z (通讯作者). Association between FGF7 and the risk of chronic obstructive pulmonary disease. Acta Pharmacol Sin. 2012,33(8):998-1003. 13. Su Z, Leduc MS, Korstanje R, Paigen B. Untangling HDL QTL on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes. J Lipid Res. 2010, 51(9): 2706-2713. 14. Su Z, Cox A, Shen Y, Stylianou I, Paigen B. Farp2 and Stk25 are candidate genes for the HDL cholesterol locus on mouse chromosome 1. Arterioscler Thromb Vasc Biol. 2009, 29(1):107-113. 15. Su Z, Ishimori N, Chen Y, Leiter EH, Churchill GA, Paigen B, Stylianou IM. Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene. J Lipid Res. 2009,50(10):2083-2094. 16. Su Z, Wang X, Tsaih SW, Zhang A, Cox A, Sheehan S, Paigen B. Genetic basis of HDL variation between 129/SvImJ and C57BL/6J mice: critical importance for testing HDL candidate genes in targeted mutant mice. J Lipid Res. 2009, 50(1):116-125. 17. Su Z, Tsaih SW, Szatkiewicz J, Shen Y, Paigen B. Candidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ. J Lipid Res. 2008, 49(7):1500-1510. 18. Su Z, Korstanje R, Tsaih SW, Paigen B. Candidate genes for obesity revealed from a C57BL/6J x 129S1/SvImJ intercross. Int J Obes (Lond). 2008, 32(7):1180-1189.