聂春来 - 四川大学 - 生物治疗国家重点实验室

个人简介

2004年在中国科学院生物物理研究所研究所获得理学博士学位。2004年-2007年在中国科学院动物研究所从事博士后研究工作。2007年受聘于四川大学生物治疗国家重点实验室，任教授、肿瘤细胞生物学研究室主任。实验室运用生物学，计算机辅助设计以及化学等相关手段，围绕实验室主流研究领域，研究肿瘤发生，发展的机制，探寻发现有效靶向肿瘤的新型药物，近年来，研究室发表高水平SCI文章数篇，包括Cell death&disease, JBC等著名期刊。

研究领域

1，天然药物的靶点鉴定。利用实验室的生物信息学软件分析可能的药物靶标，蛋白组技术筛选，生化和细胞生物学方法鉴定。 2，利用筛选的靶点，构建适合的抗体来作用靶点，达到靶向治疗的目的。 3，Bcl-2家族蛋白在肿瘤发生中的作用。 4，自噬系统的调控机制。自噬和肿瘤发生，肿瘤复发的关系。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Juan Zhang*, Yu Zhang, Wenshuang Wu, Fang Wang, Xinyu Liu, Guanghou Shui and Chunlai Nie(*). Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion. Cell Death Dis. 2017,8(10):e3151. 2. Hang Zhou, Wei Luo, Chao Zeng, Yu Zhang, Liyang Wang, Wenxiu Yao and Chunlai Nie(*). PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines. Oncotarget. 2017, 8(46): 80770-80789. 3. Yu Zhang, Xin Li, Shisheng Tan, Xinyu Liu, Xinyu Zhao, Zhu Yuan, Chunlai Nie(*). Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells. Oncotarget. 2017, 8(7):11042-11052. 4．Jinjing Wang, Wenhao Guo, Hang Zhou, Na Luo, Chunlai Nie(*), Xinyu Zhao, Zhu Yuan, Xinyu Liu, Yuquan Wei. Mitochondrial p53 phosphorylation induces Bak-mediated and caspase-independent cell death. Oncotarget. 2015, 6(19):17192-205. 5. Wenhao Guo, Yu Zhang, Zhihong Ling, Xinyu Liu, Xinyu Zhao, Zhu Yuan, Chunlai Nie(*),Yuquan Wei. Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner. Cell Death and Disease. 2015, 6:e1919. 6. Chunlai Nie(*), Yu Luo, Xinyu Zhao, Na Luo, Aiping Tong,Xinyu Liu, Zhu Yuan, Chunting Wang(*), Yuquan Wei. Caspase-9 mediates Puma activation in UCN-01-induced apoptosis. Cell Death Dis. 2014,5:e1495. 7. Jingjing Wang, Zhuang Yang, Jiaolin Wen, Feng Ma, Fang Wang, Kun Yu, Minghai Tang, Wenshuang Wu, Yinfeng Dong, Xia Cheng, Chunlai Nie(*), and Lijuan Chen(*).SKLB-M8 Induces Apoptosis Through the AKT/mTOR Signaling Pathway in Melanoma Models and Inhibits Angiogenesis With Decrease of ERK1/2 Phosphorylation. J Pharmacol Sci. 2014;126(3):198-207. 8. Chao Lin, Xin-yu Zhao, Lei Li, Huan-yi Liu, Kang Cao, Yang Wan, Xin-yu Liu, Chun-lai Nie(*), Lei Liu,Ai-ping Tong, Hong-xin Deng, Jiong Li, Zhu Yuan(*), Yu-quan Wei. NOXA-Induced Alterations in the Bax/Smac Axis Enhance Sensitivity of Ovarian Cancer Cells to Cisplatin. PLoS One. 2012, 7(5):e36722. 9. Zhiwei Zhao, Jingjing Wang, Jingsheng Tang, Xinyu Liu, Qian Zhong, Fang Wang, Wenbin Hu, Zhu Yuan(*), Chunlai Nie(*), Yuquan Wei. JNK and Akt-mediated Puma Expression in the Apoptosis of Cisplatin-resistant Ovarian Cancer Cells. Biochem J. 2012, 444(2):291–301. 10. Wenbin Hu, Fang Wang, Jingsheng Tang, Xinyu Liu, Zhu Yuan, Chunlai Nie(*), and Yuquan Wei. Pro-apoptotic protein, smac, mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent, at101. J Biol Chem. 2012, 287(1):68-80. 11. Zhu Yuan(*), Kang Cao, Chao Lin, Lei Li, Huan-yi Liu, Xin-yu Zhao, Lei Liu, Hong-xin Deng, Jiong Li, Chun-lai Nie(*), Yu-quan Wei. The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1. Mol Med. 2011;17(11-12):1262-74. Mol Med. 2011, 17(11-12): 1262-74. 12. Zhu Yuan, Fang Wang, Zhiwei Zhao, Xinyu Zhao, Ji Qiu, Chunlai Nie(*), Yuquan Wei. BIM-Mediated AKT Phosphorylation Is a Key Modulator of Arsenic Trioxide-I nduced Apoptosis in Cisplatin-Sensitive and -Resistant Ovarian Cancer Cells. PLoS One. 2011,6(5):e20586.