Jeon, Junha - University of Texas-Arlington - Department of Chemistry and Biochemistry

个人简介

University of Minnesota, Department of Chemistry, Robert L. Ferm Outstanding Graduate TA Award 2004-2005 and honorable mention 2003–2004. Korea Science and Engineering Foundation (KOSEF) Graduate Fellowship (2003-2005). B.S., Chemistry, Sungkyunkwan University, Korea (2000) M.S., Organic Chemistry, Sungkyunkwan University, Korea (2002) Ph.D., Organic Chemistry,  University of Minnesota (2009) [Hoye Research Laboratory] Postdoctoral Fellow: University  of Pennsylvania (2011) [Smith Research Laboratory] Junha Jeon joined the University of Texas at Arlington in fall of 2011. He completed a Bachelor’s and Master’s degrees in chemistry at the Sungkyunkwan University in Korea in the laboratory of Professor Chan-Mo Yu, where he studied catalytic asymmetric allylic transfer reactions for the enantioselective synthesis of dienyl and enynyl alcohols. His doctoral research was then conducted under the guidance of Professor Thomas R. Hoye at the University of Minnesota. Within the Hoye group, he focused on natural product synthesis and method development (Sequential Ring-Closing/Cross Metathesis strategy and Relay Ring-Closing Metathesis, RRCM). The doctoral thesis title was “New Applications and Strategies in Olefin Metathesis: A Total Synthesis of (+)-Gigantecin and a Total Synthesis of (+)-Peloruside A”. After completing his doctoral work, he joined the laboratory of Professor Amos B. Smith, III at the University of Pennsylvania as a Postdoctoral Fellow, where he continued to work on the natural product synthesis (nodulisporic acid A) utilizing metal mediated cyclization strategy. Additionally, he involved Asymmetric Anion Relay Chemistry (AARC) and rapid library synthesis of natural product-like compounds utilizing anion relay chemistry. The Jeon laboratory at UT Arlington is working on the development of highly innovative and efficient synthetic methods and their functional applications.

研究领域

Our research program involves synthetic organic chemistry and organometallic chemistry. We targets the discovery of innovative and practical synthetic methods with excellent regio-, stereo-, and chemoselectivity to permit access to biomedically important molecular architectures. In order to achieve the goal, our strategy is to rationally design transition-metal/ligand catalyst complexes, to understand the function of the catalysts, and to utilize them for developing innovative catalytic reaction methods. We are also engaged in synthesis of chemically and biologically significant molecules including natural and unnatural molecules. The target-oriented synthetic study not only provides planned synthetic target molecules, but also often reveals new, unprecedented interesting reactivity and selectivity. We hope to apply the lessons from discovery of new reaction methods and synthesis of bioactive molecules into therapeutic areas.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

“Reductive ortho-Silanolization of Aromatic Esters with Hydridosilyl Acetals,” Hua, Y.; Asgari, P.; Dakarapu, U. S.; Jeon, J. Chem. Commun. 2015, Accepted (DOI: 10.1039/C4CC09850A) “Rhodium-Catalyzed Alkene Hydrosilylation via a Hydride Shuttle Process by Diene Ligands: Dramatic Enhancement of Regio- and Diastereoselectivity,” Hua, Y; Nguyen, H.; Trog, G.; Berlin, A. S.; Jeon, J.* Eur. J. Org. Chem. 2014, 5890–5895. Ligand-Controlled, Norbornene-Mediated, Regio- and Diastereoselective Rhodium-Catalyzed Intramolecular Alkene Hydrosillation Reactions, Hua, Y.; Nguyen, H. H.; Scaggs, W. R.; Jeon, J. Org. Lett. 2013, 15, 3412-3415. “Allylmalonate as an Activator Subunit for Initiation of Relay Ring-Closing Metathesis (RRCM) Reactions,” Hoye, T. R.; Jeon, J.; Tennakoon, M. A. Angew. Chem. Int. Ed. 2011, 50, 2141–2143. “Total Synthesis of Peloruside A through Kinetic Lactonization and Relay Ring-Closing Metathesis Cyclization Reactions,” Hoye, T. R.; Jeon, J.; Kopel, L. C.; Ryba, T. D.; Tennakoon, M. A.; Wang, Y. Angew. Chem. Int. Ed. 2010, 49, 6151–6155. “Sequencing of Three-Component Olefin Metatheses: Total Synthesis of Either (+)-Gigantecin or (+)-14-Deoxy-9-oxygigantecin,”Hoye, T. R.; Eklov, B. M.; Jeon, J.; Khoroosi, M. Org. Lett. 2006, 8, 3383–3386. “Catalytic Asymmetric Allylic Transfer Reaction for the Enantioselective Synthesis of Dienyl and Enynyl Alcohol.” Yu, C.-M.; Jeon, M.; Lee, J.-Y.; Jeon, J. Eur. J. Org. Chem. 2001, 1143–1148. Hoye, T. R.; Jeon, J. “Metathesis Involving a Relay and Applications in Natural Product Synthesis. In Metathesis in Natural Product Synthesis. Strategies, Substrates and Catalysts,” Cossy, J.; Arseniyadis, S.; Meyer, C. Eds.; Wiley: Weinheim, 2010, Chapter 9."