韩俊宏 - 四川大学 - 生物治疗国家重点实验室

个人简介

于2005年在日本东京工业大学（Tokyo Institute of Technology）获得博士学位。2006年至2008年，在美国梅奥医学中心（Mayo Clinic）接受博士后训练；2009-2014年先后任职资深助理研究员（Senior Research Fellow），研究助理(Research Associate)和助理教授（Assistant Professor）。至今，已在包括 Science, Cell, Nature, Genes & Development, Molecular Cell, Nature Structure & Molecular Biology, Journal Biological Chemistry等国际权威学术期刊上发表多篇研究论文。研究工作被包括 Nature Reviews Molecular Cell Biology, Faculty 1000等著名期刊作重点评述。文章总影响因子216.3，总引用次数为1482次。此外，获1项美国专利。

研究领域

一、组蛋白修饰以及调控核小体组装的功能研究二、筛选肿瘤的表观遗传性治疗药物三、表观遗传学调控干细胞命运

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Junhong Han, Yuichi Tsukada, Eiji Hara, Naomi Kitamura, Toshiaki Tanaka. Hepatocyte Growth Factor Induces Redistribution of p21Cip1 and p27Kip1 Through Erk-dependent p16INK4a Up-regulation, Leading to Cell Cycle Arrest at G1 in HepG2 Hepatoma Cells. Journal of Biological Chemistry. 2005, 280:31548-31556. 2. Junhong Han, Hui Zhou, Bruce Horazdovsky, Kanling Zhang, Rui-Ming Xu, Zhiguo Zhang.Rtt109 Acetylates Histone H3 Lysine 56 and Functions in DNA Replication. Science 2007,315:653-655. (Highlighted by Nature Reviews Molecular Cell Biology， and by Faculty of 1000) 3. Sean R. Collins, Kyle M. Miller, Nancy L. Maas, Assen Roguev, Jeffrey Fillingham, Clement S.Chu, Maya Schuldiner, Marinella Gebbia, Judith Recht, Michael Shales, Huiming Ding, HongXu, Junhong Han, Kristin Ingvarsdottir, Benjamin Cheng, Brenda Andrews, Charles Boone,Shelley L. Berger, Phil Hieter, Zhiguo Zhang, Grant W.Brown, C. James Ingles, Andrew Emili,C. David Allis, David P. Toczyski, Jonathan S. Weissman , Jack F. Greenblatt, Nevan J.Krogan. Functional Dissection of Protein Complexes Involved in Yeast Chromosome BiologyUsing a Genetic Interaction Map. Nature 2007, 446: 806-810. (Highlighted by Faculty of 1000) 4. Junhong Han, Qing Li, Laura McCullough, Tim Formosa, Zhiguo Zhang. Ubiquitylation of FACT by the Cullin-E3 Ligase Rtt101 Connects FACT to DNA Replication. Genes & Development. 2010, July 15, 24(14):1485-1490. PMCID: PMC2904938.(Highlighted by Faculty of 1000) 5. Junhong Han, Hui Zhou, Z. Li, Rui-Ming Xu, Zhiguo Zhang. H3-K56 Acetylation Catalyzed by Rtt109 and Regulated by Asf1 is Required for Replisome Integrity. Journal of Biological Chemistry. 2007, 282:28587-28596. 6. Junhong Han, Hui Zhou, Zhizhong Li, Rui-Ming Xu, Zhiguo Zhang. The Rtt109-Vps75 Histone Acetyltransferase Complex Acetylates Non-nucleosomal Histone H3. Journal of Biological Chemistry. 2007, 282:14158-14164. 7. Chuanhe Yu*, Haiyun Gan*, Junhong Han, Zhixiong Zhou, Shaodong Jia, Andrei Chabes, Gianrico Farrugia, Tamas Ordog, Zhiguo Zhang. Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall. Molecular Cell. 2014 Nov.20, 54:551-563 (*Equal Contribution). 8. Karina B. Falbo*, Contance Alabert*, Yuki-Mori Katou*, Su Wu, Junhong Han, Tammy Wehr,Jing Xiao, Xiangwei He, Zhiguo Zhang, Yang Shi, Katsuhiko Shirahige, Philippe Pasero,Xuetong Sheng. Involvement of a Chromatin Remodeling Complex in DNA Damage Tolerance in DNA Replication. Nature Structural and Molecular Biology. 2009, 16:1167-1172 (*Equal Contribution). 9. Rebecca J. Burgess, Hui Zhou, Junhong Han, Zhiguo Zhang. Gcn5 Promotes Replication Coupled Nucleosome Assembly. Molecular Cell. 2010, Feb.26, 37(4):469-480. PMCID: PMC2954627. 10. Theodore J. Kottom, Junhong Han, Zhiguo Zhang, Andrew H. Limper. Pneumocystis cariniiexpress an Active Rtt109 Histone Acetyltransferase. American Journal of Respiratory Cell and Molecular Biology. 2011,44:768-776. PMCID: PMC3135839. 11. Hui Zhang, Junhong Han, Bin Kan and Zhiguo Zhang. Human HAT1 Preferentially Acetylates H3.1-H4 over H3.3-H4 Tetramers and Regulates Nucleosome Assembly of H3.1-H4. Journal of Biological Chemistry. 2012, 287, 6573-6581. 12. Rebecca J. Burgess, Junhong Han, Zhiguo Zhang. The Ddc1/Mec3/Rad17 Sliding Clamp Regulates Histone-histone Chaperone Interactions and DNA Replicaiton-Coupled Nucleosome Assembly in Budding Yeast. Journal of Biological Chemistry. 2014 Feb.25, 289:10518-10529. 13. Rebecca J. Burgess, Hui Zhou, Junhong Han, Zhiguo Zhang. The SCFDia2 Ubiquitin E3 Ligase Ubiquitylates Sir4 and Functions in Transcriptional Silencing. PLoS Genetics. 2012 Jul; 8(7): e1002846. 14. Jayme L. Dahlin, Rondedrick Sinville, Jonathan Solberg, Hui Zhou, Junhong Han, Subhashree Francis, Jessica M. Strasser, Kristen John, Derek J. Hook, Michael A. Walters, Zhiguo Zhang. A Cell-Free Fluorometric High-throughput Screen for Inhibitors of Rtt109 -catalyzed Histone Acetylation. PLoS One. 2013 Nov.18; 8(11):e78877. Doi:10.1371/journal.pone.0078877 15. Junhong Han, Hui Zhang, Honglian Zhang, Zhiquan Wang, Hui Zhou and Zhiguo Zhang. A Cul4 E3 Ubiquitin Ligase Regulates Histone Hand-off During Nucleosome Assembly. Cell. 2013. 155:817-829. (Highlighted by Faculty of 1000) 16. Jayme L. Dahlin, Theodore Kottom, Junhong Han, Hui Zhou, Michael A. Walters, Zhiguo Zhang and Andrew H. Limper. Pneumocystis Jirovecil PjRtt109: A Novel Drug Target for Pneumocystis Pneumonia in Immunosuprressed Humans. Antimicrobial Agents and Chemotherapy. 2014 July, 58:3650-3659. 17. Kuo Zhang, Yuan Gao, Jingjing Li, Rebecca Burgess, Junhong Han, Huanhuan Liang, Zhiguo Zhang, Yingfang Liu. A DNA Binding Winged Helix Domain in CAF-1 Functions with PCNA to Stabilize CAF-1 at Replication Forks. Nucleic Acids Research. 2016, doi:10.1093/nar/gkw106