郭刚 - 四川大学 - 生物治疗国家重点实验室

个人简介

省卫计委学术带头人后备人选，全国生化检测标准化技术委员会委员。主要从事新型医用高分子材料/纳米生物技术领域的研究工作，在新型可降解高分子药物载体的制备与改性方面已积累了较多研究基础，尤其是在智能高分子药物载体设计与制备以及纳米药物载体等方面有较好的前期积累。作为课题负责人和主研分别承担了国家科技重大专项、“863”计划、国家自然科学基金、中国博士后科学基金以及多项横向科研课题等项目的研究工作。

研究领域

1、新型生物降解高分子材料的设计、合成与应用；2、组织工程及再生医学材料；3、靶向纳米药物递送系统的设计与制备。

近期论文

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1.RangRang Fan, Lan Mei, Xiang Gao, YueLong Wang, MingLi Xiang, Yu Zheng, AiPing Tong*, XiaoNing Zhang, Bo Han, LiangXue Zhou, Peng Mi, Chao You, ZhiYong Qian, YuQuan Wei, Gang Guo*. Self-Assembled Bifunctional Peptide as Effective Drug Delivery Vector with Powerful Antitumor Activity. Adv Sci. 2017,4: 1600285. 2.Lan Mei, RangRang Fan, XiaoLing Li, YueLong Wang, Bo Han, YingChun Gu, LiangXue Zhou, Yu Zheng*, Aiping Tong, Gang Guo*. Nanofibers for improving the wound repair process: the combination of a grafted chitosan and an antioxidant agent. Polym Chem-UK. 2017, 8: 1664-1671. 3.YueLong Wang, Min Wu, Lei Gu, XiaoLing Li, Jun He, LiangXue Zhou*, Aiping Tong, Juan Shi, HongYan Zhu, JianGuo Xu, Gang Guo*. Effective improvement of the neuroprotective activity after spinal cord injury by synergistic effect of glucocorticoid with biodegradable amphipathic nanomicelles. Drug Deliv. 2017, 24(1): 391-401. 4.Lan Mei, Yuelong Wang, Aiping Tong, Gang Guo*. Facile electrospinning of an efficient drug delivery. Expert Opin Drug Deliv. 2016, 25: 1-13. 5.Rangrang Fan, Xiaoling Li, Jiaojiao Deng, Xiang Gao, Liangxue Zhou*, Yu Zheng, Aiping Tong, Xiaoning Zhang, Chao You & Gang Guo*. Dual Drug Loaded Biodegradable Nanofibrous Microsphere for Improving Anti-Colon Cancer Activity. Scientific Reports. 6:28373. 6.Xiang Gao, ShiMin Wang, BiLan Wang, SenYi Deng, XiaoXiao Liu, XiaoNing Zhang, LinLi Luo, RangRang Fan, MingLi Xiang*, Chao You, YuQuan Wei, ZhiYong Qian, Gang Guo*. Improving the anti-ovarian cancer activity of docetaxel with biodegradable self-assembly micelles through various evaluations. Biomaterials. 2015, 53: 646-658. 7.Rangrang Fan, Aiping Tong, Xiaoling Li, Xiang Gao, Lan Mei, Liangxue Zhou*, Xiaoning Zhang, Chao You, Gang Guo*. Enhanced antitumor effects by docetaxel/LL37-loaded thermosensitive hydrogel nanoparticles in peritoneal carcinomatosis of colorectal cancer. Int J Nanomedicine. 2015, 10: 7291–7305 8.Gang Guo, ShaoZhi Fu, LiangXue Zhou, Hang Liang, Min Fan, ZhiYong Qian*, YuQuan Wei. Preparation of curcumin loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) nanofibers and their in vitro antitumor activity against Glioma 9L cells. Nanoscale. 2011, 3 (9), 3825–3832. 9.Xiaoling Li, Rangrang Fan, Aiping Tong*, Meijia Yang, Jiaojiao Deng, Liangxue Zhou, Xiaoning Zhang, Gang Guo*. In situ gel-forming AP-57 peptide delivery system for cutaneous wound healing. Int J Pharm. 2015, 495(1): 560-571. 10. JiaoJiao Deng, YueLong Wang, LiangXue Zhou*, MaLing Gou, Na Luo, HaiFeng Chen, AiPing Tong, Chao You, Gang Guo*. Fabrication and in vivo chondrification of Poly(propylene carbonate)/l-lactide-grafted tetracalcium phosphate electrospun scaffold for cartilage tissue engineering. RSC Adv. 2015, 5: 42943–42954. 11. YueLong Wang, Gang Guo*, HaiFeng Chen, Xiang Gao, RangRang Fan, DongMei Zhang, LiangXue Zhou*. Preparation and characterization of polylactide/poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) hybrid fibers for potential application in bone tissue engineering. Int J Nanomedicine. 2014, 9: 1-13.