毕锋 - 四川大学 - 生物治疗国家重点实验室

个人简介

现任四川大学华西医院腹部肿瘤科主任；信号转导及分子靶向治疗研究室主任. 1984 年毕业于第一军医大学医疗系获学士学位；后在第四军医大学获医学硕士和博士学位并留校在第一附属西京医院全军消化疾病中心工作； 1998 年 ~2001 年在美国田纳西大学医学院从事博士后研究工作。 2001 年底回国后任第四军医大学全军消化系疾病研究所教授、主任医师、博士生导师及肿瘤病区负责人。 2005 年以人才引进方式来到华西医院任肿瘤化疗科主任并组建了以肿瘤前沿研究为主的信号转导与分子靶向治疗研究室。 2007 年肿瘤中心学科重组后任腹部肿瘤科主任.

研究领域

主要为肿瘤细胞异常信号传导及分子靶向治疗的基础与临床研究（ Rho-Dbl 家族原癌基因与肿瘤关系）；胃肠道肿瘤内科治疗的临床及基础研究，并在此基础上研发抗肿瘤分子靶向药物。

近期论文

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Liu M, Lang N, Qiu M, Bi F * . miR-137 targets Cdc42 expression, induces cell cycle G1 arrest, and inhibits invasion in colorectal cancer cells. International Journal of Cancer . 2010; 12(5): [PMID: 20473940 ， Article Production Number: 09-2853.R1 ] . Zhou J, Zhu Y, Zhang G, Tang Q, Liu M, Bi F * . A Distinct role of RhoB in Gastric Cancer Suppression. International Journal of Cancer. 2010. [PMID: 20473933 ， Article Production Number: 09-0540.R4 ] . Chen J ， Liu M ， Tang Q ， Bi F*. Epigenetic modification of RhoE expression in Gastric Cancer Cell Lines. Oncology Reports .2010. In press. Zhang SY, Tang QL, Chen XZ, Liu M, Zheng Y, Bi F* . RhoA Regulates G1/S Progression of Gastric Cancer Cells by Modulation of Multiple INK4 Family Tumor Suppressors. Molecular Cancer Research. 2009; 7(4): 570-80. Wang F , Xia P , Wu F , Wang D , Wang W , Ward T , Liu Y , Aikhionbare F , Guo Z , Powell M , Liu B , Bi F , Yao X . Helicobacter pylori VacA Disrupts Apical Membrane- Cytoskeletal Interac tions in Gastric Parietal Cells. Journal of Biological Chemistry . 2008; 283(39): 26714-26725. Liu N, Zhang G, Bi F *, Pan Y, Xue Y, Shi Y, Yao L, Zhao L, Zheng Y, Fan D. RhoC is essential for the metastasis of gastric cancer. Journal of Molecular Medicine . 2007; 85(10):1149-56. Xue Y, Bi F * , Zhang X, Zhang S, Pan Y, Liu N, Shi Y, Yao X, Zheng Y, Fan D. . Role of Rac1 and Cdc 42 in Hypoxia Induced p53 and von Hippel-Lindau Suppression and HIF1α Activation. International Journal of Cancer . 2006; 118(1):112-120. Cao X, Ding X, Guo Z, Zhou R, Wang F, Long F, Wu F, Bi F , Yao X. PALS1 specifies the localization of ezrin to the apical membrane of gastric parietal cells. Journal of Biological Chemistry . 2005; 280(14):13584-92. Pan YL, Bi F *, Liu N, Du JP, Jiang HP, Xue Y, Fan DM. Expression of seven main Rho family members in gastric carcinoma. Biochem Biophys Res Commun. 2004 , 12;315(3):686-91. Xue Y, Bi F *, Zhang X, Pan Y, Liu N, Zheng Y, Fan D. . Inhibition of endothelial cell proliferation by targeting Rac1 GTPase with small interference RNA in tumor cells. Biochem Biophys Res Commun . 2004 ; 320(4):1309-15. Liu N, Bi F *, Pan Y, Sun L, Xue Y, Shi Y, Yao X, Zheng Y, Fan D. The inhibition of RhoA expression and activity partially reversed the malignant phenotype of gastric cancer cells. Clinical Cancer Research . 2004; 10(18):6239-47. Bi F , Liu N, Fan D. Small interfering RNA: a new tool for gene therapy. Current Gene Therapy. 2003 , 3(5): 411-7. Himmel KL, Bi F , Shen H, Jenkins NA, Copeland NG, Zheng Y, Largaespada DA. Activation of Clg by proviral insertion at Evi24, a common integration site in B cell and myeloid Leukemia. Journal of Biological Chemistry . 2002; 277(16): 13463-72. Bi F , Debreceni B, Zhu K, Salani B, Eva A, Zheng Y. Autoinhibition Mechanism of Proto-Dbl. Molecular and Cellular Biology. 2001; 21(5): 1463-1474 . Bi F *, Fan D, Hui H, Wang C, Zhang X. . Reversion of the malignant phenotypes of gastric cancer by c-erbB-2 specific ribozymes. Cancer Gene Therapy . 2001; 8(11):835-42. Zhu K, Debreceni B, Bi F , Zheng Y. . Oligomerization of DH domain is essential for dbl-induced transformation. Molecular and Cellular Biolology . 2001; 21(2): 425-437