吴传芳 - 四川大学 - 生命科学学院

个人简介

学位简历：1996.09.01-2000.06.30 四川大学生命科学学院生物学基地班本科 2000.09.01-2003.06.30四川大学生命科学学院生物化学与分子生物学专业硕士 2003.09.01-2006.06.30 四川大学生命科学学院植物学专业博士工作简历 2006.07.01-至今四川大学生命科学学院工作

研究领域

1.肿瘤相关蛋白质的表达、纯化及与之相互作用的功能性逆转座子ncRNA的筛选、鉴定工作，阐明ncRNA与蛋白质间的作用对细胞分化和肿瘤发生发展中的调控作用等。 2.植物凝集素纯化、生物学活性与结构关系研究以及基因的克隆、序列分析和重组蛋白的表达纯化等工作。

近期论文

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Tao Liu, Lei Wu, Di Wang, Haiyang Wang, Jinwu chen, Chunlan Yang, Jinku Bao, and Chuanfang Wu. Role of reactive oxygen species mediated MAPK and NF-κB activation in Polygonatum cyrtonema lectin induced apoptosis and autophagy in human lung adenocarcinoma A549 cells. The Journal of Biochemistry. (Accepted) （通讯作者） 2. Jinwu Chen, Xiaojie Li, Dengjiao Ma, Tao Liu, Pingping Tian, Chuanfang Wu.CERS4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through NF-κB signaling pathway. Oncology Letters.（Accepted）（通讯作者） 3. wu lei; Tao Liu; Yan Xiao; Xing Li; Yanan Zhu; Yan Zhao; Jinku Bao; Chuanfang Wu Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a-3p. International Journal of Biological Macromolecules. (Accepted)（通讯作者） 4. Tao Liu,Yu Yang,Di Wang, Yan Xiao, Guangshi Du, Lei Wu, Muran Ding,Ling Li, and Chuanfang Wu. Human eukaryotic elongation factor 1A forms oligomers through specific cysteine residues. Acta Biochim Biophys Sin, 2015.47（12）：1011-1017 （通讯作者） 5. Yang Lan, Cheng-en Wang, and Chuan-Fang Wu.Crop Plant Genotyping by Real-Time PCR Analysis of Crude Extracts of Seeds. JournaL of AOAC International. 2015,98（1）：1-4（通讯作者） 6. Ziyi Zhao, Lan Wu, Huimin Shi,Chuanfang Wu. A novel polymerase chain reaction system allows for the direct amplification for crop leaf tissue without DNA isolation. Res. J.Biotechnol. 2014, 9, 32-37. （通讯作者） 7. Bangmin Lu, Bin Zhang,Wei Qi , Yanan Zhu, Jinku Bao, and Chuanfang Wu. Conformational study reveals amino acid residues essential for hemagglutinating and anti-proliferative activities of Clematis montana lectin. Acta Biochim Biophys Sin 2014, 46: 923–934(IF:2.089) （通讯作者） 8. Lei Zhang, Qing Zhang, Yu Yang, and Chuanfang Wu*. The RNA recognition motif domains of RBM5 are required for RNA binding and cancer cell proliferation inhibition. Biochemical and Biophysical Research Communications.2014. 444(3):445-50（IF:2.5）通讯作者 9. Ziyi Zhao, Lan Wu, Huimin Shi and Chuanfang Wu*.17β-Estradiol treatment inhibits breast cell proliferation, migration and invasion by decreasing MALAT-1 RNA level. Biochemical and Biophysical Research Communications。2014.445(2):388-93 通讯作者 10. Ziyi Zhao, Lan Wu, Huimin Shi and Chuanfang Wu*. p53 N‑terminal binding and stabilisation by PIAS3 inhibits MDM2‑induced p53 ubiquitination and regulates cell growth.MOLECULAR MEDICINE REPORTS. 2014;9(5):1903-8. 通讯作者 11. Wuchuanfang，Tanguanghong，Machengchuan，Liling. The Non-Coding RNA Llme23 Drives the Malignant Property of Human Melanoma Cells. Journal of Genetics and Genomics.2013. 40（4）：179-188（IF:2.076） 12. Yao Q, Wu CF(并列第一作者), Luo P, Xiang XC, Liu JJ, Mou L, Bao JK*. A new chitin-binding lectin from rhizome of Setcreasea purpurea with antifungal, antiviral and apoptosis-inducing activities. Process Biochemistry. 2010. 45(9): 1477-1485. 13. Zhao Q, Wu CF(并列第一作者), Wang WG, Yuan S, Bao JK, Chen F. In vitro plantlet regeneration system from rhizomes and mannose-binding lectin analysis of Polygonatum cyrtonema Hua. Plant Cell, Tissue and Organ Culture. 2009. 99(3): 269-275. 14. Xu XC, Wu CF, Liu C, Luo YT, Li J, Zhao XP, Damme EV, Bao JK*. Purification and Characterization of a Mannose-Binding Lectin from the Rhizomes of Aspidistra elatior Blume with Antiproliferative Activity. Acta Biochimica et Biophysica Sinica (Shanghai). 2007. 39(7): 507-519 15. An J, Liu JZ, Wu CF, Li J, Dai L, Van Damme E, Balzarini J, De Clercq E, Chen F, Bao JK*. Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua. Acta Biochimica et Biophysica Sinica (Shanghai). 2006. 38(2):70-8. 16. Wu CF, Li J, An J, Chang LQ, Chen F, Bao JK*. Purification, Biological Activities, and Molecular Cloning of a Novel Mannose-Binding Lectin from Bulbs of Zephyranthes candida Herb (Amaryllidaceae). Journal of Integrative Plant Biology. 2006. 48(2):223-231. 17. Gao S, An J, Wu CF, Gu Y, Chen F, Yu Y, Wu QQ, Bao JK*. Effect of amino acid residue and oligosaccharide chain chemical modifications on spectral and hemagglutinating activity of Millettia dielsiana Harms. ex Diels. Lectin. Acta Biochimica et Biophysica Sinica (Shanghai). 2005. 37(1): 47-54. 18. Gong M, An J, Lü HZ, Wu CF, Li YJ, Cheng JQ, Bao JK*. Effects of denaturation and amino acid modification on fluorescence spectrum and hemagglutinating activity of Hericium erinaceum Lectin. Acta Biochimica et Biophysica Sinica (Shanghai). 2004. 36(5):343-350 19. Wu CF, An J, He XJ, Deng J, Hong ZX, Liu Chao, Lu HZ, Li YJ, Wang CJ, Chen F, Bao JK*. Molecular Cloning of a Novel Mannose-binding Lectin Gene from Bulbs of Amaryllis vittata (Amaryllidaceae). Acta Botanica Sinica. 2004. 46(11):1301-1306.