曹洋 - 四川大学 - 生命科学学院

个人简介

工作经历： 2011-2014，四川大学，生命科学学院，讲师 2014-今，四川大学，生命科学学院，副教授教育经历： 2016-2017，美国密歇根大学，生物信息学，访学 2004-2010，中国科学院生物物理研究所，生物信息学，博士 2000-2004，西南交通大学，应用物理学，学士

研究领域

1）探索蛋白质的序列、结构、功能三者密切联系的奥秘 2）探索人工设计非天然蛋白质的方法，赋予其生物学特性 3）探索高效开发靶向药物的计算方法 4）探索在生物数据海洋中挖掘信息的方法

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Cao Y*, Li L., Improved protein-ligand binding affinity prediction by using a curvature dependent surface area model, Bioinformatics, 30(12):1674-80. 2014 2. Huang L#, Cao Y#, Zhou J, Qin K, Zhu W, Zhu Y, Yang L, Wang D, Wei H*, Shu Y*., A conformational restriction in influenza A virus neuraminidase binding site by R152 caused the combinational effect of I222T with H274Y on oseltamivir resistance. Antimicrob Agents Chemother. 58(3), 1639-1645, 2014 (#co-first author) 3. Cao Y, Song L, Miao Z, Hu Y, Tian L, Jiang T*. Improved side-chain modeling by coupling clash-detection guided iterative search with rotamer relaxation. Bioinformatics. 27(6): 785-790. 2011 4. Cao Y, Koh X, Dong L, Du X, Wu A, Ding X, Deng H, Shu Y, Chen J, Jiang T*. Rapid Estimation of Binding Activity of Influenza Virus Hemagglutinin to Human and Avian Receptors. PLoS One. 6(4):e18664. 2011 5. Guo J#, Cao Y#, Qin K, Zhao X, Wang D, Li Z, Xin L, Shu Y, Zhou J. Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro. Biochem Biophys Res Commun. 458(1):77-81. 2015 (#co-first author) 6. Bu C, Peng B, Cao Y, Wang X, Chen Q, Li J, Shi G. Novel and selective acetylcholinesterase inhibitors for Tetranychus cinnabarinus (Acari: Tetranychidae).Insect Biochem Mol Biol. 66:129-35. 2015 7. Miao Z, Cao Y, Jiang T. "Modeling of protein side-chain conformations with RASP", Protein Structure Prediction, 3rd Edition (Methods in Molecular Biology), Edited by D. Kihara, ISBN: 978-1-4939-0365-8 (Print) 978-1-4939-0366-5 (Online). Springer, 2014 8. Larson AM, Wang H, Cao Y, Jiang T, Chen J, Klibanov AM*. Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activity. J Pharm Sci. 101(10): 3896-905. 2012 9. Miao Z, Cao Y, Jiang T*. RASP: rapid modeling of protein side chain conformations, Bioinformatics. 27(22): 3117-22. 2011 10.Hu Y, Dong X, Wu A, Cao Y, Tian L, Jiang T*. Incorporation of local structural preference potential improves fold recognition. PLoS One. 6(2): e17215. 2011 11.Zhao Y, Zhang Y, Cao Y, Qi J, Mao L, Xue Y, Gao F, Peng H, Wang X, Gao GF, Ma Y*. Structural analysis of alkaline β-Mannanase from alkaliphilic Bacillus sp. N16-5: implications for adaptation to alkaline conditions. PLoS One. 6(1): e14608. 2011 12.Du X, Wang Z, Wu A, Song L, Cao Y, Hang H, Jiang T. Networks of genomic co-occurrence capture characteristics of human influenza A (H3N2) evolution. Genome Research, 18(1): 178–187, 2008