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个人简介

1994年西南大学本科毕业,获学士学位 1997年四川大学细胞遗传硕士毕业,同年留校任教 2002年香港中文大学做访问学者,同年破格晋升为副教授 2005年获得四川大学理学博士学位 2007.1-2008.1在University of Pittsburgh国家公派访问学者 2013.11-2014.1在University of Pittsburgh国家公派高级访问学者 2007年起任四川大学教授和博士生导师

研究领域

主要研究细胞增殖、分化以及细胞凋亡、自噬过程中,细胞命运转变的分子调控机制,并关注药物对细胞命运调控的作用机制及细胞耐药产生机制。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Dong Yang, Bin Sun, Xiaohong Zhang, Daomei Cheng, Xiaoping Yu, Lanzhen Yan, Lei Li, Sanqi An, Hua Jiang, Anna Lasorella, Antonio Iavarone, Shu Zhang, Fangdong Zou*, Xudong Zhao*, Huwe1 sustains normal ovarian epithelial cell transformation and tumor growth through the histone H1.3-H19 cascade, Cancer Research, 2017, Sept 15, 77(18):4773-4784 2. Shu Gong, Dongsheng Xu, Fangdong Zou*, Rui Peng, (−)-Curine induces cell cycle arrest and cell death in hepatocellular carcinoma cells in a p53-independent way, Biomedicine & Pharmacotherapy, 2017, 89: 894–901 3. Jingshan Tong#, Shuai Tan#, Zaneta Nikolovska-Coleska, Jian Yu, Fangdong Zou*, Lin Zhang*, FBW7-dependent Mcl-1 degradation mediates the anticancer effect of Hsp90 inhibitors, Molecular Cancer Therapeutics, 2017. Sep, 16(9):1979-1988 4. Jingshan Tong, Peng Wang, Shuai Tan, Dongshi Chen, Zaneta Nikolovska-Coleska, Fangdong Zou, Jian Yu, and Lin Zhang*, Mcl-1 degradation is required for colon cancer cell killing by targeted therapy, Cancer Research, 2017 May 1, 77(9): 2512-2521 5. Shengwei Li, Xiaoping Gao, Rui Peng, Sheng Zhang, Wei Fu, Fangdong Zou*, FISH-based analysis of clonally derived CHO cell populations reveals high probability for transgene integration in a terminal region of chromosome 1 (1q13), Plos One, 2016 DOI:10.1371/ journal.pone.0163893 6. JingShan Tong, Shuai Tan, Fangdong Zou, Jian Yu and Lin Zhang, FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation, Oncogene, 2017 February 09; 36(6): 787–796 7. Brown M, Leibowitz B, Chen D, He K, Fangdong Zou, Sobol R, Stolz D, Zhang L, Yu J*, Loss of Caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis. Cell Death & Disease, 2015 Apr 23;6:e1729. doi: 10.1038/cddis.2015.104 8. Si Li, Zhaoxuan Deng, Jingyan Fu, Caiyue Xu, Guangwei Xin, Zhige Wu, Jia Luo, Gang Wang, Shuli Zhang, Boyan Zhang, Fangdong Zou*, Qing Jiang, Chuanmao Zhang*, Spatial compartmentalization specializes function of Aurora-A and Aurora-B, Journal of Biological Chemistry, 2015. 290: 17546-17558 9. Brian Leibowitz, Wei Qiu, Monica E. Buchanan, Fangdong Zou, Philip Vernon, Mary Pat Moyer, Xiao-Ming Yin, Robert E. Schoen, Jian Yu*, and Lin Zhang*, BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs, Proc Natl Acad Sci USA, 2014 Nov 18;111(46):16520-16525 10. Dongshi Chen, Lihua Ming, Fangdong Zou, Ye Peng, Bennett Van Houten, Jian Yu, Lin Zhang, TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity, Oncotarget, 2014, 5(18): 8107-8122. 11. Rui Peng, Jingshan Tong, Hua Li, Bisong Yue, Fangdong Zou*, Jian Yu, Lin Zhang*,Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation, Cell Death and Differentiation, 2013, 20: 744-754(IF8.339,获Faculty 1000推荐) 12. Si Li, Zhu Liang, Liu Xu, Fangdong Zou*, microRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases, Molecular and Cellular Biochemistry, 2012, 360: 147-158 13. Li Ou, Xiaochen Wang and Fangdong Zou*, Is iPS cell the panacea? IUBMB Life, 2010, 62(3): 170-175 14. Peng Wang#, Fangdong Zou#(Co-first author), Xiaodong Zhang, Hua Li, Austin Dulak, Robert J. Tomko, Jr., John S. Lazo, Zhenghe Wang, Lin Zhang, and Jian Yu*, microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells, Cancer Research, 2009, 69 (20): 8157-8165 (IF 9.122) 被引用300次,据Web of Science,学术领域中最优秀的Top 1%论文 15. Yan Fan, Zan Tong, Jiefang You, Fangdong Zou*, Mingxiao Ding, Hongkui Deng, Nanog reporter system in mouse embryonic stem cells based on high efficient BAC homologous recombination, Chinese Science Bulletin, 2007, 52 (2): 2782-2788.

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