个人简介

EDUCATION Massachusetts Institute of Technology Cambridge, MA NIH Postdoctoral Research Fellow with Professor Timothy Swager 2008-2010 Columbia University, Graduate School of Arts and Sciences New York, NY Ph.D., Chemistry 2008 Doctoral Thesis: Investigating the Origin of Homochirality Doctoral Advisor: Professor Ronald Breslow M.A., Chemistry 2005 Columbia University, Columbia College New York, NY B.A., Chemistry 2003 AWARDS AND FELLOWSHIPS NIH Postdoctoral Fellowship 2008-2010 National Postdoctoral Association Travel Award 2010 Pegram Award for Excellence in Research 2008 Women Chemists Committee Eli Lilly Travel Award 2007 Novartis Graduate Fellowship in Organic Chemistry 2005-2006 RESEARCH EXPERIENCE Massachusetts Institute of Technology, Department of Chemistry, Cambridge, MA 2008-2010 NIH Postdoctoral Research Fellow with Professor Timothy Swager Developed new sensor systems for potential disease detection. Synthesized near infrared-emitting squaraine dyes, studied the energy transfer between organic polymers and the squaraine dyes in thin films, solutions, and injectable nanoparticles. Resulted in first-author publication published, book chapter accepted that incorporates this work, two oral presentations at national chemistry conferences, departmental presentation to 25 graduate students and postdoctoral fellows. Columbia University, Department of Chemistry, New York, NY 2004-2008 Graduate Research Assistant with Professor Ronald Breslow Studied the origin of homochirality on earth. Amplified enantiomeric concentrations of amino acids under credible prebiotic conditions, demonstrated partial transfer of chirality from α-methyl amino acids to proteinogenic amino acids, synthesized enantiopure α-methyl amino acids found on meteorites. Resulted in six publications in peer-reviewed journals, lecture at national chemistry conference, departmental award for excellence in research, four posters, presentation at MIT to 30 students and postdoctoral fellows, presentation 2 at Columbia University to 25 students, postdoctoral fellows, and faculty. Research publicized in popular science magazines and featured in Chemical and Engineering News. Wyeth Pharmaceutical Company, Pearl River, NY 2003 Undergraduate Intern Optimized reaction conditions for the ortho-acetylation of anilines using microwave-assisted organic synthesis. Columbia University, Department of Chemistry, New York, NY 2002 Undergraduate Research Assistant with Professor Dalibor Sames Researched the fluorescent profile of small molecule probes. Synthesized new probes and tested their reactivity with proteins. Schneider Children’s Hospital, Department of Pediatric Gastroenterology, Queens, NY 1998 Research Intern Researched trends in presentation and treatment of inflammatory bowel disease. Created and analyzed database of more than 100 patients. Resulted in two publications in peer-reviewed journals.

研究领域

Organic Chemistry

We are initiating an exciting research program in supramolecular organic chemistry. There are two main projects currently underway in our group: Dissymmetric Organic Macrocycles: The synthesis of a variety of electronically dissymetric organic macrocycles will be explored and optimized. These macrocycles, many of which will be fluorescent, will be utilized for several applications, such as organocatalysis, fluorescent sensing, self-assembly, and chiral recognition. Chiral Polyamines: A variety of chiral polyamines will be synthesized, characterized, and utilized for the intracellular delivery of DNA and siRNA.

近期论文

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Marks, P.; Radaram, B.; Levine, M. Levitsky, I.A. " Highly efficient detection of hydrogen peroxide in solution and in the vapor phase via fluorescence quenching." Chemical Communications. 2015 51, 7061-7064.[Download]< Chaudhuri, S.; Phelan, T.; Levine, M. " Cyclodextrin-promoted Diels Alder reactions of a polycyclic aromatic hydrocarbon under mild reaction conditions." Tetrahedron Letters . 2015, accepted.[Download]< Serio, N.; Chanthalyma, C.; Peters, S.; Levine, D.; Levine, M. " 2-Hydroxy propyl beta-cyclodextrin for the enhanced performance of dual function extraction and detection systems in complex oil environments." Journal of Inclusion Phenomena and Macrocyclic Chemistry . 2014, accepted.[Download]< Radaram, B.; Levine, M. " A green bromination method for the synthesis of benzylic dibromides." Tetrahedron Letters . 2014, accepted.[Download]< Serio, N.; Prignano, L.; Peters, S.; Levine, M. "Detection of Medium-Sized Polycyclic Aromatic Hydrocarbons via Fluorescence Energy Transfer." Polycyclic Aromat.Compd. 2014,accepted.[Download] Serio, N.; Chanthalyma, C.; Prignano, L.; Levine, M. "Cyclodextrin-Enhanced Extraction and Energy Transfer of Carcinogens on Complex Oil Environments." Appl. Mater. Interfaces. 2013, 5 (22), 11951-11957.[Download] Serio, N.; Chanthalyma, C.; Prignano, L.; Levine, M. "Cyclodextrin Promoted Energy Transfer for Broadly Applicable Small Molecule Detection." Supramol. Chemistry. 2013, [Download] Radaram, B.; Mako, T.K.; Levine, M. "Sensitive and selective detection of cesium via fluorescence quenching." Dalton. Trans.,. 2013, 42, 16276-16278.[Download]< Justin Gharavi, J.; Marks, P.; Moran, K.; Kingsborough,B.; Verma, R.; Chen, Y.; Deng, R.; Levine.M."Chiral cationic polyamines for chiral microcapsules and siRNA delivery."Bioorganic & Medicinal Chemistry Letters. 2013, 23, 5919-5922[Download]< Patrick, M.; Cohen, S.; Levine, M. "Highly Efficient Quenching of Nanoparticles for the Detection of Electron-Deficient Nitroaromatics." J. Polym. Sci. Part A: Polymer Chemistry. 2013, 51, 4150-4155.[Download]< Radaram, B.; Potvin, J.K.; Levine, M. "Highly efficient non-covalent energy transfer in all-organic macrocycles." Chem. Commun. 2013, 49, 8259-8261.[Download]< Mako, T.; Levine, M. "Synthesis of a Fluorescent Conjugated Polymer in the Undergraduate Organic Teaching Laboratory." J. Chem. Ed. 2013, 90, 1376-1379.[Download] Serio, N.; Miller, K.; Levine, M. "Efficient detection of polycyclic aromatic hydrocarbons and polychlorinated biphenyls via three-component energy transfer." Chem. Commun. 2013, 49, 4821-4823.[Download] Mueller, P.; Fronczek, F. R.; Smith, S. J.; Mako, T.; Levine, M. "Two polymorphs of 1,8-dichloroanthracene." Acta Cryst . C 2013, 69, 199-203.[Download] Teresa Mako, Patrick Marks, Nicole Cook and Mindy Levine. "Fluorescent Detection of Polycyclic Aromatic Hydrocarbons in Ternary Cyclodextrin Complexes" Supramolecular Chemistry 2012[Download] Patrick Marks & Mindy Levine. "Synthesis of a Near-Infrared Emitting Squaraine Dye in an Undergraduate Organic Laboratory" J. Chem. Educ. 2012 [Download] Louis Marchetti and Mindy Levine. "Biomimetic Catalysis". ACS Catal. 2011 [Download] Tahirat Nasiru, Luis Avila and Mindy Levine. "Determination of Critical Micelle Concentrations Using UV-Visible Spectroscopy". J. High School Res. 2011. [Download] Mindy Levine, Inja Song, Trisha L. Andrew, Steven E. Kool and Timothy M. Swager. "Photoluminescent Energy Transfer from Poly(phenyleneethynylene)s to Near-Infrared Emitting Fluorophores". J. Poly. Sci. A, Polymer Chem. 2010 [Download] Ronald Breslow, Mindy Levine and Zhan-Ling Cheng. "Imitating Prebiotic Homochirality on Earth". Orig Life Evol Biosph 2010 [Download]