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个人简介

1991.9-1995.6,四川大学生物系生物化学专业学士 1995.9-1998.6,四川大学生物系生物化学专业硕士 1998.9-2001.6,中国科学院化学研究所化学博士 2001.10-2005.1,美国肯塔基大学细胞与分子生物化学系博士后 2010.2-2012.9, 美国塔夫茨大学营养与衰老研究中心博士后 2005.7- 四川大学生命科学学院教授

研究领域

1. 氧化胁迫对机体的破坏以及机体的防御和应答,衰老过程中蛋白质的损伤和周转代谢以及相关信号通路。 2. 光合作用光化学反应及活性氧自由基的产生与调控。 3. 自由基生物技术在环保、健康和美容领域的应用。

近期论文

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1. Qie, B., Lyu, Z., Lyu, L., Liu, J., Gao, X., Liu, Y., Duan, W., Zhang, N., Du, L., and Liu, K. (2015) Sch9 regulates intracellular protein ubiquitination by controlling stress responses. Redox biology 5, 290-300 2. Liu, K. *, Lyu, L., Chin, D., Gao, J., Sun, X., Shang, F., Caceres, A., Chang, M. L., Rowan, S., Peng, J., Mathias, R., Kasahara, H., Jiang, S., and Taylor, A*. (2015) Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract. Proceedings of the National Academy of Sciences of the United States of America 112, 1071-1076 3. Shang, F., Wilmarth, P. A., Chang, M. L., Liu, K., David, L. L., Caceres, M. A., Wawrousek, E., and Taylor, A. (2014) Newborn mouse lens proteome and its alteration by lysine 6 mutant ubiquitin. Journal of proteome research 13, 1177-1189 4. Liu, J., Lu, L., Qie, B.-B., and Liu, K.* (2014) Regulation of The Phosphorylation of Yeast Protein Kinase Sch9 Under Environmental Changes and During Chronological Aging. Progress in Biochemistry and Biophysics 41, 192-201 5. Du, L., Miao, X., Gao, Y., Jia, H., Liu, K.*, and Liu, Y.* (2014) The protective effects of Trolox-loaded chitosan nanoparticles against hypoxia-mediated cell apoptosis. Nanomedicine : nanotechnology, biology, and medicine 10, 1411-1420 6. Liu, J., Huang, X., Withers, B. R., Blalock, E., Liu, K.*, and Dickson, R. C.* (2013) Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan. Aging Cell 12, 833-841 7. Lin, J., Yu, Y., Shigdar, S., Fang, D. Z., Du, J. R., Wei, M. Q., Danks, A., Liu, K., and Duan, W. (2012) Enhanced antitumor efficacy and reduced systemic toxicity of sulfatide-containing nanoliposomal doxorubicin in a xenograft model of colorectal cancer. PloS one 7, e49277 8. Du, L., Miao, X., Jia, H., Gao, Y., Liu, K.*, Zhang, X., and Liu, Y.* (2012) Detection of nitric oxide in macrophage cells for the assessment of the cytotoxicity of gold nanoparticles. Talanta 101, 11-16 9. 贺曾, 杜立波, 姜玉岗, 陈良兵, 王广清, 田秋, 刘科*, 杜林方, and 刘扬*. (2010) 内源性超氧阴离子自由基介导的莱茵衣藻光系统Ⅱ蛋白组分损伤. 生物物理学报 v.26, 301-308 10. 苗敏, 曹红平, 钟彦, 刘军, 王一慧, 刘昕, 张年辉, and 刘科*. (2009) 出芽酵母Saccharomyces cerevisiae转录抑制因子Rdr1负调控细胞胁迫应答. 生物化学与生物物理进展 v.36, 1544-1552 11. 曹红平, 王一慧, 钟彦, 刘昕, 苗敏, 刘科*. (2009) 过量表达蛋白激酶YPK1使酵母细胞对高盐胁迫的高度敏感依赖于雷帕霉素靶蛋白. 微生物学报 v.49;No.v.49, 1069-1074 12. Zhang, W., Smith, A., Liu, J. P., Cheung, N. S., Zhou, S., Liu, K., Li, Q. T., and Duan, W. (2009) GSK3beta modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner. Cellular signalling 21, 237-245 13. 袁瀚, 韩璐, 杜立波, 田秋, 刘科, 杜林方, 刘扬. (2008) 单细胞光合生物莱茵衣藻光系统Ⅱ产生超氧阴离子自由基的ESR研究. 生物化学与生物物理进展, 1065-1069 14. Lim, W. G., Chen, X., Liu, J. P., Tan, B. J., Zhou, S., Smith, A., Lees, N., Hou, L., Gu, F., Yu, X. Y., Du, Y., Smith, D., Verma, C., Liu, K.*, and Duan, W.* (2008) The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner. Archives of biochemistry and biophysics 479, 170-178 15. Liu, K., Zhang, X., Sumanasekera, C., Lester, R. L., and Dickson, R. C. (2005) Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae. Biochemical Society transactions 33, 1170-1173 16. Liu, K., Zhang, X., Lester, R. L., and Dickson, R. C. (2005) The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9. The Journal of biological chemistry 280, 22679-22687 17. Liu, K., Sun, J., Song, Y. G., Liu, B., Xu, Y. K., Zhang, S. X., Tian, Q., and Liu, Y. (2004) Superoxide, Hydrogen Peroxide and Hydroxyl Radical in D1/D2/cytochrome b-559 Photosystem II Reaction Center Complex. Photosynthesis research 81, 41-47 18. Xu, Y. K., Chen, Z. W., Sun, J., Liu, K., Chen, W., Shi, W., Wang, H. M., and Liu, Y. (2002) Synthesis, crystal structure, and ESR study of a novel phosphorylated lipophilic spin trap. The Journal of organic chemistry 67, 7624-7630

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