个人简介
2001- 2005 复旦大学,生命科学,本科 2005- 2012 麻省大学医学院,生化和分子制药系,博士 2012- 2014 美国辉瑞制药,药物安全研发部,博士后 2014- 2015 美国辉瑞制药,药物安全研发部,Senior Scientist 2015- 至今 四川大学生命科学学院教授 2017- 至今 兼任生命科学学院副院长
研究领域
长期从事体细胞重编程,胚胎干细胞自更新和定向分化以及非编码RNA调控机制方面的研究
近期论文
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1. Zheng Z, Hu H, Tong Y, Hu Z, Cao S, Shan C, Lin W, Yin Y, Li Z*. MiR-27b regulates podocyte survival through targeting adenosine receptor 2B in podocytes from non-human primate. Cell Death Dis. (2018) 9(11):1133. IF:6.187 2. Li Z, Rana TM. Decoding the noncoding: prospective of lncRNA-mediated innate immune regulation. RNA Biol. (2014) 11:979-85. IF:4.974 3. Li Z, Rana TM. Therapeutic Targeting of MicroRNAs: Current Status and Future Challenges. Nat Rev Drug Discov. (2014). 13:622-38. IF:57 4. Li Z(共同一作), Dang J, Rana TM. MicroRNA-mediated regulation of extracellular matrix formation modulates somatic cell reprogramming. RNA (2014). 20:1900-15. IF:4.94 5. Li Z(共同一作), Chao TC, Chang K, Lin N, Burns JC, Rana TM*. The long non-coding RNA THRIL regulates TNFα expression through its interaction with hnRNPL. Proc Natl Acad Sci USA. (2014). 111:1002-7. IF:9.661 6. Henzler CM, Li Z(共同一作), Dang J, Arcila ML, Zhou H, Liu J, Chang KY, Bassett DS, Rana TM*, Kosik KS*. Staged miRNA re-regulation patterns during reprogramming. Genome Biol. (2013). 14:R149. IF:11.908 7. Li Z, Rana,TM*. A Kinase library screen identifies small molecule activators of iPS cell Reprogramming. Nat Commun. (2012) 3:1085. IF:12.124 8. Li Z, Rana, TM*. Molecular Mechanisms of RNA-triggered Gene Silencing Machineries. Accounts Chem Res. (2012) 45: 1122-31. IF:20.955 9. Li Z, Yang,CS., Nakashima, K., Rana, TM*. Small RNA-mediated regulation of iPS cell Generation. EMBO J (2011) 30:823-34. IF:9.792