韩源平 - 四川大学 - 生命科学学院

个人简介

2.教育经历 1978-1982, 四川大学, 生物系, 主修生物化学, 学士学位 1990-1996, 西奈山医学院 (The Mount Sinai School of Medicine, New York), 主修生物医学科学（Biomedical Science）, 获博士学位，Ph.D. 导师, Dr. Ronald A. Kohanski 1996-1999, 南加大洛杉矶儿童医院Los Angeles Children’s Hospital/University of Southern California, 博士后 (1996-1999), 导师, Dr. Yun-Kai (Teddy) Fong 3.研究工作经历 1982-1985, 地质矿产部工艺研究所, 助理研究员 1985-1989, 四川抗菌素研究所, 助理研究员 1989-1990, SmithKline Pharmaceuticals (葛兰素史克, 美国, 费城), 从事新药发现研究 2000-2003, 南加州大学 University of Southern California, Keck School of Medicine, 助理研究员 2004-2011, 南加州大学 University of Southern California, Keck School of Medicine, 助理教授 (Assistant Professor at Tenure Track)。 USC Keck School of Medicine, PIBBS 博士研究生导师。 2004年-现在，南加州大学，Keck School of Medicine, 酒精肝病及胰腺疾病研究中心会员 2011-至今首都医科大学，北京佑安医院客座教授 2012-至今，Cedars-Sinai Medical Center (Los Angeles), 客座教授，项目合作。 2012-至今, 四川大学，生命科学学院，教授。

研究领域

从事肝星状细胞及肝硬化，以及脂肪肝（NASH）的机理研究。他呈经在制药领域（GSK，葛兰素史克研发总部,以及四川抗生素研究所）从事新药物的开发研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Yuan-Ping Han, Kohanski RA. “Phenylarsine oxide inhibits insulin activation of phosphatidylinositol 3'-kinase”. Biochem Biophys Res Commun 1997 Oct 9;239 (1):316-21. 2. Frankel M, Bishop SM, Ablooglu AJ, Yuan-Ping Han, Kohanski RA. “Conformational changes in the activation loop of the insulin receptor's kinase domain”. Protein Science 1999 Oct; 8(10): 2158-65. 3. Yuan-Ping Han, Tuan TL, Wu H, Hughes M, Garner WL. “TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-kappa B mediated induction of MT1-MMP”. Journal of Cell Science 2001; 114(Pt 1):131-139. 4. Yuan-Ping Han, Tai-Lan Tuan, Huayang Wu, Michael Hughes, Warren L. Garner. “TGF-beta and TNF-alpha mediated induction and proteolytic activation of MMP-9 in human skin”. Journal of Biological Chemistry. 2001, vol.276 (25); 22341-22350. 5. Yuan-Ping Han, Micheal W. Hughes, Yih-Dar Nien and Warren L. Garner. “IL-8-Stimulated Expression of Urokinase-Type Plasminogen Activator in Human Skin and Human Epidermal Cells”. Journal of Surgery Research. 2002 Aug;106(2):328. 6. Mei Chen, Fritz K. Costa, Christopher R. Lindvay, Yuan-Ping Han, and David T. Woodley. “The Recombinant Expression of Full-length Type VII Collagen and Characterization of Molecular Mechanisms Underlying Dystrophic Epidermolysis Bullosa”. Journal of Biological Chemistry. 2002, vol. 277: 2118-2124. 7. Yuan-Ping Han, Yih-Dar Nien and Warren L.Garner. “Recombinant human platelet-derived growth factor and transforming growth factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by Rho/GTPase inhibitor but not require phosphatidylinositol-3’ kinase”. Wound Repair and Regeneration. 2002, vol. 10, 169-176. 8. Yuan-Ping Han*, Yih-Dar Nien and Warren L.Garner. “TNF-alpha mediated proteolytic activation of pro-MMP-9 in human skin is controlled by down regulation of the tissue inhibitor, TIMP-1 and mediated by tissue bound chymotrypsin-like proteinase”. Journal of Biological Chemistry. 2002, 277: 27319-27327. 9. Yuan-Ping Han, Yih-Dar Nien and Warren L.Garner. “Fibrinogen inhibits fibroblast-mediated contraction of collagen”. Wound Repair and Regeneration. 2003 Sep;11(5):380-385. 10. Yuan-Ping Han*, Ling Zhou, Jiaohong Wang, Shigang Xiong, Warren L. Garner, Samuel W. French, Hidekazu Tsukamoto. “Essential role of matrix metalloproteinases in interleukin-1 induced myofibrobalstic activation of hepatic stellate cell in collagen”. Journal of Biological Chemistry. 2004, vol. 279, 4820-4828 11. Yuan-Ping Han, Downey S and Warren L.Garner. “Interleukin-1alpha-induced proteolytic activation of metalloproteinase-9 by human skin”. Surgery. 2005 Nov;138(5):932-9. 12. Yuan-Ping Han*. “Matrix metalloproteinases, the pros and cons, in liver fibrosis”. Journal of Gastroenterology & Hepatology. 2006 Oct; 21 Suppl 3:S88-91. 13. Yuan-Ping Han*, Chunli Yan, Ling Zhou, Lan Qin, and Hidekazu Tsukamoto. “A Matrix Metalloproteinase-9 Activation Cascade by Hepatic Stellate Cells in Trans-differentiation in the hree-dimensional Extracellular Matrix”. Journal of Biological Chemistry. 2007 Apr 27;282(17):12928-39 14. Goldberg MT, Han YP, Yan C, Shaw MC, Garner WL. “TNF-alpha Suppresses alpha-Smooth Muscle Actin Expression in Human Dermal Fibroblasts: An Implication for Abnormal Wound Healing”. Journal of Investigative Dermatology. 2007 May 31;127 (11):2645-55 15. Cheng JH, She H, Han YP, Wang J, Xiong S, Asahina K, Tsukamoto H. “Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis”. American Journal of Physiololy, (Gastrointest Liver Physiol) 2007, Nov 15; [Epub ahead of print] PMID: 18006602 16. Yuan-Ping Han*, Chunli Yan and Warren L Garner. “Proteolytic Activation of Matrix Metalloproteinase-9 in Skin Wound Healing Is Inhibited by alpha-1-Antichymotrypsin”. Journal of Investigative Dermatology. 2008 September; 128(9): 2334–2342. 17. Chunli Yan, Ling Zhou, and Yuan-Ping Han*. “Contribution of hepatic stellate cells and matrix metalloproteinase-9 in acute liver failure”. Liver International. 2008 May 26. [Epub ahead of print]. 18. Cheng CF, Fan J, Fedesco M, Guan S, Li Y, Bandyopadhyay B, Birght AM, Yerushalmi D, Liang M, Chen, Han YP, Woodley DT, Li W. “Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing”.