个人简介

2009-current Assistant Professor, Bioanalytical Chemistry Department of Chemistry, University of Rhode Island 2009-current Co-founder & VP Research and Development Insight Nanofluidics, Inc. 2008-2009 Postdoctoral Fellow Applied Biophysics Lab, University of British Columbia 2005-2007 NSERC Postdoctoral Fellow Max Born Institute, Berlin, Germany 2005 Doctor of Philosophy in Physical Chemistry University of Toronto Significant Awards Year Award 2013 Early Career Faculty Research Excellence Award: Life Sciences, Physical Sciences and Engineering, URI Division of Research and Economic Development 2012-2017 NSF CAREER AWARD CBET- 1150085 2005-2007 1998-2002 NSERC Postgraduate & Postdoctoral Fellowships

研究领域

Analytical/Nanoscience

Bioanalytical, materials & biophysical chemistry -powered by nanoscience Building and Using the Molecular-Scale Laboratory In the quest for molecular-level information, molecular-scale tools are a powerful and desirable scientific goal. Our research program is centered on the development of a new class of nanofabricated device based on nanopores. In its simplest form, a nanopore is nothing more than a molecular-sized hole in an insulating membrane. Yet even in this configuration, it is capable of being used to detect and manipulate single molecules. With careful device engineering, it is possible to create powerful sensors for the detection of disease biomarkers at low levels early in the onset of disease, or of trace amounts of toxins, to name but two targets. Configured differently, nanopore-based devices can be used to probe the intermolecular interactions that underpin biological function: applications range from testing new pharmaceutical drug candidates to exploring the fundamental biophysics governing processes such as antibody-antigen recognition. Our research program is focused on conceiving of, fabricating and then optimizing the nanopore devices that will make possible these challenging goals. We use the techniques and principles of nanofabrication, materials science, biophysics and analytical chemistry to design and create the molecular-scale tools that will allow us to sense and manipulate molecules one at a time.

近期论文

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J. Phys. Chem. Lett. (2013) 4, 2339. Nanofluidic cells with controlled path length and liquid flow for rapid, high-resolution in situ Imaging with Electrons. Rev. Sci. Instrumen. (2013) 84, 036101. An environmental cell for transient spectroscopy on solid samples in controlled atmospheres. J. Phys. Chem. C (2012) 116, 23315. Conductance-Based Determination of Solid-State Nanopore Size and Shape: An Exploration of Performance Limits. J. Phys. Chem. A (2011) 115, 13149. QTAIM investigation of the electronic structure and large Raman scattering intensity of Bicyclo-[1.1.1]-pentane. ACS Nano (2009) 3, 3009. Single-molecule bonds characterized by solid-state nanopore force spectroscopy. Chem. Phys. (2009) 357, 36. Ultrafast dynamics of N-H and O-H stretching excitations in hydrated DNA oligomers. J. Phys. Chem. B. (2008) 112, 11194. Ultrafast vibrational dynamics of adenine-thymine base pairs in DNA oligomers. Springer Series in Chemical Physics, Ultrafast Phenomena XVI (2008). Ultrafast vibrational dynamics of adenine-thymine base pairs in hydrated DNA. Chem. Phys. (2007) 341, 175. Ultrafast vibrational dynamics and anharmonic couplings of hydrogen-bonded dimers in solution. J. Mod. Opt. (2007) 54, 923. Experimental basics for femtosecond electron diffraction studies. J. Mod. Opt. (2007) 54, 905. Femtosecond electron diffraction: An atomic perspective of condensed phase dynamics. Springer Series in Chemical Physics, Ultrafast Phenomena XV (2007) 88, 335. 2D-IR photon echo spectroscopy of liquid H2O—Combination of novel nanofluidics and diffractive optics deciphers ultrafast structural dynamics. Chem. Phys. Lett. (2006) 432, 146. Ultrafast dynamics of vibrational N-H stretching excitations in the 7-azaindole dimer. Phil. Trans. Roy. Soc. A (2006) 364, 741. Femtosecond electron diffraction: “Making the molecular movie”. Nature (2005) 434, 199. Ultrafast memory loss and energy redistribution in the hydrogen bond network of liquid H2O. Springer Series in Chemical Physics, Ultrafast Phenomena XIV (2005) 79, 144. Femtosecond electron diffraction: Towards making the “molecular movie”. Chem. Phys. (2004) 299, 285. Femtosecond electron diffraction studies of strongly driven structural phase transitions. Science (2003) 302, 1382. An atomic level view of melting using femtosecond electron diffraction. Springer Series in Chemical Physics, Ultrafast Phenomena XIII (2003) 322. Ultrafast electron optics: Propagation dynamics and measurement of femtosecond electron packets. J. Appl. Phys. (2003) 94, 807. Response to “Comment on `Ultrafast electron optics: Propagation dynamics of femtosecond electron packets’”.