Krishnamurthy, Ramanarayanan - The Scripps Research Institute

研究领域

Origins of Life Studies: We utilize the tools of synthetic organic chemistry and methodology to try and understand the chemical process of life: its origins, its evolution and its current state. Molecular Bio-mimicry and Chemical Biology: We are interested in expanding the repertoire of artificial informational polymers with a goal to relate the structural variation with the expression of emergent properties. Chemical Therapeutics: The alternative targets and intermediates produced in the above endeavors provide a new, and rich, source of structurally and functionally wide-ranging molecules that would be useful from a medicinal chemistry viewpoint. We are working closely with groups at TSRI to screen and evaluate the biological activity of these novel compounds and intermediates synthesized in our laboratories.

近期论文

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Nucleobases in Meteorites to Nucleobases in RNA and DNA? Krishnamurthy, R.; Goldman, A.D.; Liberies, D. A.; Rogers, K. L.; Tor, Y. J. Mol. Evol. 2022. https://doi.org/10.1007/s00239-022-10069-x Prebiotic Synthesis of α-amino acids orotate from α-ketoacids potentiates a transition to extant metabolic pathways. Pulletikurti, S.; Yadav, M.; Springsteen, G.; Krishnamurthy, R. Nat. Chem. 2022. https://www.nature.com/articles/s41557-022-00999-w Frontiers in Prebiotic Chemistry and Early Earth Environments. Müller, U.F.; Elsila, J.; Trail, D.; DasGupta, S.; Giese, C-C.; Watlon, C. R.; Cohen, Z. R.; Stolar, T.; Krishnamurthy, R.; Lyons, T.; Rogers, K. L.; Williams, L.D. Orig. Life Evol. Biosph. 2022. Synthesis and Hydrolytic Stability of Cyclic Phosphatidic Acids: Implications for Synthetic- and Proto-cell Studies. Egas, V. O; Pulletikurti, S.; Kollery, V. S.; Krishnamurthy. Chem. Commun. 2022, 58, 6231-6234. This article is part of the themed collection: 2021 CRSI Medal Winners Collection Cyanide as a primordial reductant enables a protometabolic reductive glyoxylate pathway. Yadav, M.; Pulletikurti, S.; Yerabolu, J. R.; Krishnamurthy, R. Nat. Chem. 2022, 14, 170-178. A Plausible Prebiotic One-Pot Synthesis of Orotate and Pyruvate Suggestive of Common Protometabolic Pathways. Clay, A. P.; Cooke, R. E.; Kumar, R.; Yadav, M.; Krishnamurthy, R.; Springsteen, G. Angew. Chemie. Int. Ed. 2022, e202112572. Concurrent Prebiotic Formation of Nucleoside-Amidophosphates and Nucleoside-Triphosphates Potentiates Transition from Abiotic to Biotic Polymerization. Lin, H.; Jiménez, E. I.; Arriola, J. T.; Müller, U.; Krishnamurthy, R. Angew. Chemie. Int. Ed. 2022, 61, e202113625. Depsipeptide Nucleic Acids: Prebiotic Formation, Oligomerization, and Self-Assembly of a New Proto-Nucleic Acid Candidate. Fialho, D. M.; Karunakaran, S. C.; Greeson, K. W.; Martinéz, I.; Schuster, G. B.; Krishnamurthy, R.; Hud, V. J. Am. Chem. Soc. 2021, 143, 13525-13537. Towards an understanding of the molecular mechanisms of variable unnatural base pair behavior—A biophysical analysis of dNaM-dTPT3. Karadeema, R. J.; Morris, S. E., Lairson, L. L.; Krishnamurthy, R. Chem. Eur. J. 2021, 27, 13991-13997. Separations of Carbohydrates with Noncovalent Shift Reagents by Frequency-Modulated Ion Mobility-Orbitrap Mass Spectrometry. McKenna, K. R.; Clowers, B. H.; Krishnamurthy, R.; Liotta, C. L.; Fernández, F. M. J. Am. Soc. Mass Spectrom. 2021, 32, 9, 2472–2480 Diamidophosphate (DAP) – A Plausible Prebiotic Phosphorylating Reagent with a Chem to BioChem Potential? Osumah, A.; Krishnamurthy, R. ChemBioChem, 2021, 22, 3001-3009. (Open Access) Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II. Oh. J.; Shin, J.; Unarta, C. I.; Wang, W.; Feldman, A. W.; Karadeema, R. J.; Xu, L.; Xu, J.; Chong, J.; Krishnamurthy, R.; Huang, X.; Romesberg, F. E.; Wang, D. Nat. Chem. Biol. 2021, 17, 906-914 Prebiotic Phosphorylation and Concomitant Oligomerization of Deoxynucleosides to form DNA. Jiménez, E. I.; Gibard, C.; Krishnamurthy, R. Angew. Chemie. Int. Ed. 2021, 60, 10775-10783 Figure.png Noncovalent Helicene Structure between Nucleic Acids and Cyanuric Acid. Alenaizan, A.; Fauche, K.; Krishnamurthy, R.; Sherril., D. C. Chem. Eur. J. 2021, 27, 4043-4052. The Unexpected Base‐pairing Behavior of Cyanuric Acid in RNA and Ribose versus Cyanuric Acid Induced Helicene Assembly of Nucleic Acids: Implications for the pre‐RNA Paradigm. Anderson, B.; Fauche, K.; Karunakaran, S.; Yerabolu, J.; Hud, N.; Krishnamurthy, R. Chem. Eur. J. 2021, 27, 4033-4042. Prebiotically plausible RNA activation compatible with ribozyme-catalyzed ligation. Song, E. Y.; Jiménez, E. I.; Lin, H.; Lay, K. V.; Krishnamurthy, R.; Mutschler, H. Angew. Chemie. 2020, 60, 2952-2957. Systems Chemistry in the Chemical Origins of Life: The 18th Camel Paradigm. Krishnamurthy, R. J. Systems Chem. 2020, 8, 40-62 (Special Issue Dedicated to Günter von Kiedrowski). OPEN ACCESS A Plausible Metal-Free Ancestral Analogue of the Krebs Cycle Composed Entirely of alpha-ketoacids. Stubbs, R.T.; Yadav, M.; Krishnamurthy, R.; Springsteen, G. Nat. Chem. 2020. 12, 1016-1022 Organic Acid Shift Reagents for the Discrimination of Carbohydrate Isobars by Ion Mobility-Mass Spectrometry. McKenna, K. R.; Krishnamurthy, R.; Liotta, C.; Fernandez, F. Analyst, 2020 145, 8008-8015 A Sensitive Quantitative Analysis of Abiotically Synthesized Short Homopeptides using Ultraperformance Liquid Chromatography and Time-of-Flight Mass Spectrometry. Parker, E. T.; Karki, M.; Glavin, D. P.; Dworkin, J. P.; Krishnamurthy, R. J. Chrom. A 2020, 1630, 461509