徐亮 - 四川大学 - 华西药学院

个人简介

1993～1997 华西医科大学药学院获理学学士学位 1997～2000 华西医科大学药学院获药物化学硕士学位 2000～2003 四川大学华西药学院获药物化学博士学位, 师从王锋鹏教授 2003～2005 中科院上海有机化学研究所博士后, 师从林国强院士 2005～2007 美国科罗拉多州立大学化学系博士后, 师从史一安教授 2007～ 2015 四川大学华西药学院副教授 2015～至今四川大学华西药学院教授

研究领域

1. 不对称合成新方法学及其在天然药物分子合成中的应用 2. 活性天然含氮有机物的全合成研究

近期论文

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1. Dai-Hui Tang, Ding Ma, Hang Cheng, Yong-Li Li, and Liang Xu*, A bio-inspired synthetic route to the core ring systems of Spiraea atisine-type diterpenoid alkaloids and related diterpenes, Org. Biomol. Chem. 2016, 14, 2716–2722. 2. Min-Li Jiang, Yin-Juan Meng, Wei-Yan Xiong, Liang Xu*, Construction of functionalized ABEF ring system of C20-diterpenoid alkaloid racemulosine, Tetrahedron Lett. 2016, 57, 1610–1612. 3. Hang Cheng, Fan-Hao Zeng, Xue Yang, Yin-Juan Meng, Liang Xu*, and Feng-Peng Wang，Collective Total Syntheses of Atisane-Type Diterpenes and Atisine-Type Diterpenoid Alkaloids: (±)-Spiramilactone B, (±)-Spiraminol, (±)-Dihydroajaconine, and (±)-Spiramines C and D, Angew. Chem. Int. Ed. 2016, 55, 392 –396. (Highlighted by Chin. J. Org. Chem. 2016, 36, 437; Synfacts 2016, 12, 0119). 4. Jie Li, Liang Xu*, Novel C2-symmetric six-membered NHCs for asymmetric copper-catalysed conjugate addition of Grignard reagents to 3-methylhexenone, Tetrahedron 2015, 71, 2858−2862. 5. Ding Ma, Hang Cheng, Chunmei Huang, Liang Xu*, Synthesis of the azatricyclic ACD ring system of calyciphylline A-type Daphniphyllum alkaloids via a nonstabilized azomethine ylide generated by desilylation, Tetrahedron Lett. 2015, 56, 2492–2495. 6. Wei Zhang, Hang Cheng, Yongli Li, Chunmei Huang, Liang Xu*, A new approach toward the bicyclo[3.2.1]octenes via a carbocation-based cyclization from unusually functionalized seven-membered ring precursors, Tetrahedron 2015, 71, 4967−4973. 7. Hang Cheng, Fan-HaoZeng, Ding Ma, Min-Li Jiang, Liang Xu*, and Feng-Peng Wang, Expedient Construction of the ABEF Azatetracyclic Ring Systems of Lycoctonine-Type and 7,17-seco-Type C19-Diterpenoid Alkaloids, Org. Lett. 2014, 16, 2299−2301. 8. Ru-Huai Mei, Zhi-Gang Liu, Hang Cheng, Liang Xu*, and Feng-Peng Wang, Synthesis of the 10-Azatricyclo[3.3.2.04,8]decane Core of C20-Diterpenoid Alkaloid Racemulsonine via Iodine(III) Promoted Transannular Aziridination Reaction, Org. Lett. 2013, 15, 2206−2309. 9. Zhi-Gang Liu, Hang Cheng, Meng-Jia Ge, Liang Xu*, Feng-Peng Wang PIDA-promoted intramolecular transannular aziridination to synthesize bridged azatricyclic amines related to methyllycaconitine, Tetrahedron 2013, 69, 5431-5437. 10. Zhi-Gang Liu, Liang Xu*, Qiao-Hong Chen, Feng-Peng Wang, Construction of A/E/F ring systems of C19-diterpenoid alkaloids with both C-1and C-6 oxygen functions Tetrahedron 2012, 68, 159−165. 11. Hang Cheng, Liang Xu*, De-Lin Chen, Qiao-Hong Chen, Feng-Peng Wang, Construc-tion of functionalized B/C/D ring system of C19-diterpenoid alkaloids via intramolecularDielseAlder reaction followed by Wagner-Meerwein rearrangement Tetrahedron 2012, 68, 1171−1176. 12. Jie Li, Liang Xu*, Feng-Peng Wang, New cytotoxic Myrsinane_typediterpenes from Euphorbia prolifera, Helv. Chim. Acta. 2010, 93, 746.