何勤 - 四川大学 - 华西药学院

个人简介

1989年6月毕业于华西医科大学药学院药化专业获理学学士学位，1997年6月华西医科大学药学院药剂学专业获理学硕士学位，2003年四川大学华西药学院药剂学专业获理学博士学位； 2004～2005 韩国 Kolmar株式会社中心研究院研究员。2002-2007年，四川大学华西药学院副教授，硕士生导师；2007年至今任四川大学华西药学院药剂学教授，博士生导师。

研究领域

1.药物新剂型与新制剂研究: 新型注射剂，缓控释制剂，速释制剂的研究 2.肿瘤靶向递药系统的研究：构建新型纳米递药系统靶向肿瘤, 改善肿瘤微环境，抗肿瘤转移 3.脑靶向递药系统的研究:着力于提高治疗脑部疾病药物的递送效率

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1．Yang Long, Zhengze Lu, Ling Mei, Man Li, Kebai Ren, Xuhui Wang, Jiajing Tang, Zhirong Zhang, and Qin He*. Enhanced Melanoma-Targeted Therapy by “Fru-Blocked” Phenyboronic Acid-Modified Multiphase Antimetastatic Micellar Nanoparticles. Advanced Science, 2018, 1800229. 2．Yang Wang, Kairong Shi, Li Zhang, Guanlian Hu, Jingyu Wan, Jiajing Tang, Sheng Yin, Jiandong Duan, Ming Qin, Neng Wang, Dandan Xie, Xinle Gao, Huile Gao, Zhirong Zhang, and Qin He*. Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin. Autophagy,2016, 12(6):1-14. 3.Yang Wang, Yue Qiu, Sheng Yin, Li Zhang, Kairong Shi, Huile Gao, Zhirong Zhang, and Qin He*. A functional nanocarrier that copenetrates extracellular matrix and multiple layers of tumor cells for sequential and deep tumor autophagy inhibitor and chemotherapeutic delivery. Autophagy, 2017, 13(2), 359-370. 4.Qianyu Zhang, Rui Ran,Li Zhang,Yayuan Liu, Ling Mei, Zhirong Zhang, Huile Gao, Qin He*.Simultaneous delivery of therapeutic antagomirs with paclitaxel for the management of metastatic tumors by a pH-responsive anti-microbial peptide-mediated liposomal delivery system. Journal of Controlled Release, 2015, 197: 208-218. 5.Shaobo Ruan, Mingqing Yuan, Li Zhang, Guanlian Hu, Jiantao Chen, Xingli Cun, Qianyu Zhang, Qin He* and Huile Gao*. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials, 2015,37:425-435. 6.Yang Wang, Xiaowei Tai, Li Zhang, Yayuan Liu, Huile Gao, Jiantao Chen, Kairong Shi, Qianyu Zhang, Zhirong Zhang, Qin He*. A novel antitumour strategy using bidirectional autophagic vesicles accumulation via initiative induction and the terminal restraint of autophagic flux. Journal of Controlled Release, 2015,199:17-28. 7.Kairong Shi , Jianping Li , Zhonglian Cao , Ping Yang , Yue Qiu , Bo Yang, YangWang , Yang Long,Yayuan Liu , Qianyu Zhang , Jun Qian , Zhirong Zhang , Huile Gao , Qin He*.A pH-responsive cell-penetrating peptide-modified liposomes withactive recognizing of integrin αvβ3 for the treatment of melanoma. Journal of Controlled Release ,2015,217:138–150. 8.Yayuan Liu, Rui Ran, Jiantao Chen, Qifang Kuang, Jie Tang, Ling Mei, Qianyu Zhang, Huile Gao, Zhirong Zhang, Qin He*.Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting. Biomaterials,2014,35:4835-4847. 9. Ling Mei, Yayuan Liu, Qianyu Zhang, Huile Gao, Zhirong Zhang, Qin He*. Enhanced antitumor and anti-metastasis efficiency via combined treatment with CXCR4 antagonist and liposomal doxorubicin. Journal of Controlled Release. 2014, 196: 324-331. 10.Qianyu Zhang, Jie Tang, Ling Fu, Rui Ran, Yayuan Liu, Mingqing Yuan, Qin He*. A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system. Biomaterials,2013,34(32):7980-7993.