黄园 - 四川大学 - 华西药学院

个人简介

1989-1993 华西医科大学药学院，获理学学士学位 1993-1996 华西医科大学药学院，获药剂学硕士学位 2000-2003 四川大学华西药学院，获药剂学博士学位 1996- 四川大学华西药学院药剂系任助教、讲师、副教授、教授 2001-2002 美国马里兰大学药学院药剂学教研室访问学者

研究领域

1、靶向给药系统的构建及其作用机制研究：包括口服胃肠道定位释药系统的研究；口服蛋白多肽类药物给药系统的研究；肿瘤靶向给药系统的研究 2、药物新剂型、新制剂的研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Wei Shan, Xi Zhu, Min Liu, Lian Li, Jiaju Zhong, Wei Sun, Zhirong Zhang and Yuan Huang*. Overcoming the Diffusion Barrier of Mucus and Absorption Barrier of Epithelium by Self-Assembled Nanoparticles for Oral Delivery of Insulin. ACS nano. DOI: 10.1021/acsnano.5b00028 2.Yang Qingqing, Yang Yang, Li Lian, Sun Wei, Zhu Xi, Huang Yuan*. Polymeric Nanomedicine for Tumor-Targeted Combination Therapy to Elicit Synergistic Genotoxicity against Prostate Cancer. ACS Applied Materials & Interfaces. DOI: 10.1021/am509204u 3.Chun Hui Chen, Xi Zhu, Yan Feng Dou, Jian Zhang, Ting Ting Fan, Zhi Rong Zhang, Yuan Huang*, Jun Rong Du, Ke Liu, Yi Hong Deng, Li Yan Zhao. Exendin-4 loaded SLNs with mixed solid lipid shell and incorporated micelles: Optimization, characterization and pharmacodynamics. J. Biomed. Nanotechnol. 2015;11:865-876. 4.Zhou Zhou, Lian Li, Yang Yang, Xiuli Xu and Yuan Huang*. Tumor targeting by enhanced cross-linked N-(2-hydroxypropyl) methacrylamide Copolymer Micelles with pH-sensitivity and Biodegradability. Biomaterials. 2014;35(24):6622-35. 5.Lian Li, Qingqing Yang, Zhou Zhou, Jiaju Zhong, Yuan Huang*. A tumor extracellular acidity-triggered charge-reversible system based on HPMA copolymers for improved doxorubicin delivery: a strategy for overcoming the folate dilemma. Biomaterials. 2014;35: 5171-5187 6.Tingting Fan, Chunhui Chen, Han Guo, Juan Xu, Jian Zhang, Xi Zhu, Yang Yang, Zhou zhou, Lian Li, Yuan Huang*. Design and evaluation of solid lipid nanoparticles modified with peptide ligand for oral delivery of protein drugs. European J. Pharm. & Biopharm. 2014,88(2):518-28 7.Yang Yang, Lian Li, Zhou Zhou, Qingqing Yang, Chong Liu, Yuan Huang*. Targeting of G3-C12-modified N-(2-hydroxypropyl) methacrylamide copolymers to prostate carcinoma. Molecular Pharmaceutics. 2014;11(10):3251-60 8.Jian Zhang, Xi Zhu, Yun Jin, Wei Shan, Yuan Huang*. Mechanism Study of Cellular Uptake and Tight Junction Opening Mediated by Goblet Cell-Specific Trimethyl Chitosan nanoparticles. Molecular Pharmaceutics. 2014;11(5):1520-32. 9.Xi Zhu, Wei Shan, Peiwen Zhang, Yun Jin, Tingting Fan, Yang Yang, Zhou Zhou, Yuan Huang*. Penetration derivative-based nanocomplexes for insulin oral delivery: enhanced mucosal permeation and the mechanism. Molecular Pharmaceutics. 2014, 11 (1), 317–328 10.Chunhui Chen , Tingting Fan , Yun Jina, Zhou zhou, Yang Yang, Xi Zhu, Zhi-rong Zhang, Qiang Zhang, Yuan Huang*. Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle–double emulsion method via the combined use of different solid lipids. Nanomedicine. 2013; 8(7):1085-100 11.Yang Yang, Zhou Zhou, Shuang He, Tingting Fan, Yun Jin, Xi Zhu, Chunhui Chen, Zhi-rong Zhang, Yuan Huang*. Treatment of prostate carcinoma with (Galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates. Biomaterials. 2012;33:2260-2271 12.Yun Jin, Yupin Song, Xi Zhu, Dan zhou, Chunhui Chen, Zhirong Zhang, Yuan Huang*. Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport. Biomaterials. 2012；33：1573-1582.