个人简介

Education B.S. in Chemistry, 1988, Nanjing Normal University M.S. in Chemistry, 1993, Shanghai Institute of Materia Medica Ph.D. in Chemistry, 2000, North Carolina State University Postdoctoral Fellowship in Chemistry, 2001, University of Arizona

研究领域

Catalysis Chemical Biology and Biochemistry Organic Chemistry Pharmaceutical Chemistry

Our laboratory is interested in developing innovative chemical technologies and strategies to solve chemical and biological problems. Currently we are working on three areas: organocatalysis; molecular imaging and recognition; and chemical biology and medicinal chemistry.

近期论文

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Wang, J.; Li, H.; Zu, L.-S.; Jiang, W.; Xie, H.-X.; Duan, W.-H.; Wang, W.* “Enantioselective Organocatalytic Conjugate Additions to Enones” J. Am. Chem. Soc., 2006, 128, in press. Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Organocatalytic Michael Addition of N-Heterocycles to Nitroolefins” Synthesis, 2007, invited to contribute to Practical Synthetic Procedures (PDS-Articles in Synthesis. Zu, L.-S.; Wang, J.; Li, H.; Yu, X-H.; Wang, W.* “A Recyclable Fluorous (S)-Pyrrolidine Sulfonamide Promoted Direct, Highly Enantioselective Michael Addition of Ketones and Aldehydes to Nitroolefins in Water” Org. Lett., 2006, 8, 3077-3079. (This work has been highlighted in http://www.organic-chemistry.org/abstracts/lit1/320.shtm). Liu, S.-Y.; Fan, Y.-P.; Peng, X.-X.; Wang, W.;* Hua, W.-Y.; Akber, H.; Liao, L.-X.* “A Concise and Enantioselective Approach to the Total Synthesis of (-)-Lasubine I” Tetrahedron Lett., 2006, in press. Wang, J.; Heikkinen, L. D.; Li, H.; Zu, L.-S.; Jiang, W.; Wang, W.* “Quinine-Catalyzed Enantioselective Michael Addition of Diphenyl Phosphite to Nitroolefins: Synthesis of Chiral Precursors of a-Substituted b-Amino Phosphonates” Submitted to Adv. Synth. Catal.. Wang, W.;* Li, H.; Wang, J.; Zu, L.-S.; “Enantioselective Organocatalytic Tandem Michael-Aldol Reactions: One-Pot Synthesis of Chiral Thiochromenes” J. Am. Chem. Soc., 2006, 128, 10354-10355. Wang, J.; Li, H.; Zu, L.; Jiang, W.; Wang, W.* “Organocatalytic, Enantioselective Conjugate Addition of Nitroalkanes to Nitroolefins” Adv. Synth. Catal., 2006, in press. Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Enantioselective Organocatalytic Michael Addition Reactions between N-Heterocycles and Nitroolefins” Org. Lett., 2006, 8, 1391-1394. Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Highly Enantioselective Organocatalytic Michael Addition Reactions of Ketones with Chalcones” Adv. Synth. Catal., 2006, 348, 425-428. Zu, L.-S.; Wang, J.; Li, H.; Yu, X-H.; Wang, W.* “Highly Enantioselective Aldehyde-Nitroolefin Michael Addition Reactions Catalyzed by Recyclable Fluorous (S) Diphenylpyrrolinol Silyl Ether” Tetrahedron Lett., 2006, 47, 5131-5134. Zhang, S.-L.; Duan, W.-H.;* Wang, W.* “Efficient, Enantioselective Organocatalytic Synthesis of Trichostatin A” Adv. Synth. Catal., 2006, 348, 1228-1234. Li, H.; Wang, J.; Zu, L.-S.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to b-Nitrostyrenes” Tetrahedron Lett., 2006, 47, 2585-2589. Li, H.; Zu, L.-S.; Wang, J.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to Enones” Tetrahedron Lett., 2006, 47, 3145-3148. Mei, Y.; Bentley, P. A.; Wang, W. “A Selective and Sensitive Chemosensor for Cu2+ Based on 8-Hydroxyquinoline” Tetrahedron Lett., 2006, 47, 2447-2449. Wang, J.; Li, H.; Lou, B.; Zu, L.-S.; Guo, H.; Wang, W.* “Enantio- and Diastereoselective Michael Addition Reactions of Unmodified Aldehydes and Ketones with Nitroolefins Catalyzed by a Pyrrolidine Sulfonamid” Eur. J. Chem., 2006, 12, 4321-4332. Wang, J.; Li, H.; Yu, X.-H.; Zu, L-S.; Wang, W.* “Chiral Binaphthyl-Derived Amine-Thiourea Organocatalyst Promoted Asymmetric Morita-Baylis-Hillman Reaction” Org. Lett., 2005, 7, 4293-4296. (This work has been recognized as Org. Lett. Hot Paper) Wang, J.; Li, H.; Duan, W.-H.; Zu, L-S.; Wang, W.* “Organocatalytic Asymmetric Michael Addition of 2,4-Pentandione to Nitroolefins” Org. Lett., 2005, 7, 4713-4716. (This work has been recognized as Org. Lett. Hot Paper) Wang, J.; Li, H.; Mei, Y.; Lou, B.; Xu, D.; Xie, D.; Guo, H.; and Wang, W.* “Direct, Facile Aldehyde and Ketone a-Selenenylation Reactions Promoted by L-Prolinamide and Pyrrolidine Sulfonamide Organocatalysts” J. Org. Chem. 2005, 70, 5678-5687. Wang, W.;* Li, H.; Wang, J. “Pyrrolidine Sulfonamide Promoted Direct, Enantioselective Aldol Reactions of a, a-Dialkyl Aldehydes: Synthesis of Quaternary Carbon-Containing b-Hydroxy Carbonyl Compounds” Tetrahedron Lett., 2005, 46, 5077-5079. Wang, W.;* Li, H.; Wang, J. “Enantioselective, Organocatalytic Mukaiyama-Michael Addition of Silyl Ethers to a, b-Unsaturated Aldehydes” Org. Lett., 2005, 7, 1637-1639.