何菱 - 四川大学 - 华西药学院

个人简介

1980.9～1984.7 四川医学院药学系药物化学专业学士。 1989.9～1992.6 华西医科大学药学院药物化学专业（与中国科学院上海有机化学研究所联合培养）硕士。 1992.9～1993.7 中国科学院上海有机化学研究所合成一室进修。 1996.10～1997.10 美国堪萨斯大学医学中心药学系药物发展实验室访问学者。 1997.10～1999.3 美国德克萨斯理工大学化学及生物化学系访问学者。 2002.9～2003.9 香港大学化学系研究。 2004.9～2008.6 四川大学化学学院有机化学专业获博士学位 1984.12～华西医科大学药学院有机化学教研室；化学实验II教研室；药物化学教研室助教、讲师、副教授、教授。

研究领域

1.多功能氮源的转移反应性研究及其在药物合成中的应用 2.简单金属盐及配合物参与的区域选择性反应与绿色制药技术 3.基于神经网络的肿瘤靶向微波热疗增敏剂的构效关系研究

近期论文

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1. Nan Liu, Bo-Yang Tang, Yue Chen, Li-Juan Chen, Ling He*. Catalyzed Imidation of Tertiaryamine by Simple Copper Salt. Europing Journal of Organic Chemistry 2009, 2059~2062. 2. Yan Jiang, Guo-Chuan Zhou, Guang-Li He, Ling He*, Ju-Lian Li, Shi-Long Zheng. Ruthenium (II) Porphyrin-Catalyzed Selective N-Imidation of Aromatic Nitrogen Heterocycles. Synthesis, 2007, 10, 1459~1464. 3. Zhuan Fang, Guo-Chuan Zhou, Shi-Long Zheng, Guang-Li He, Ju-Lian Li, Ling He*, Di Bei. Lithium chloride-catalyzed selective demethylation of aryl methyl ethers under microwave irradiation. Journal of Molecular catalysis A:Chemical. 2007, 274, 16~23. 4. Ling He, Jing Yu, Ji Zhang, Xiao-Qi Yu*. Catalyzed Amidation of Cyclic Ethers by Simple Copper Salt and Preparation of Aminoalcohols. Organic Letters, 2007. 9（12）2277~2280. 5. Ling He, Qin Wang, Guo-Chuan Zhou, Lei Guo, Xiao-Qi Yu*. Copper-Catalyzed Cleavage of Benzyl Ethers with DiacetoxyiodoBenzene and p-Toluenesulfonamide. Arkivoc, 2008；xii：103-108. 6. Ling He，Philip Wai Hong, Wai-Man Tsui, Wing-Yiu, and Chi-Ming Che*. Ruthenium (II)Prophyrin-Catalyzed Amidation of Aromatic Heterocyclic. Organic Letters, 2004, 6 (14), 2405~2408. 7. Ling He*，Ju-lian Li, Jian-Jun Zhang, Pu Su and Shi-Long Zheng. Microwave assisted synthesis of melatonin. Synthetic Communications, 2003，33，741. 8. Ling He*, He Xi Chang, Ting Chao Chou,Niramol Savaraj,C. C. Cheng*. Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern -synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives. European Journal of Medicinal Chemistry, 2003, 38,101-107. 9. Yu Jing, Zhang Wen Wen,Li Ying Hong,Li Sheng Nan, He Ling*. Asymmetric Synthesis of Nebivolol. Chinese Journal of Organic Chemistry 2008; 28 (3): 511-514. 10. Xiao-Ai Wu, Ping Ying, Jun-Yang Liu, Heng-Shui Shen, Yue Chen, Ling He*. Lithium chloride-catalyzed selective 'hydrolysis' of methyl esters under microwave rradiation. Synthetic Communications, 2009，in press 11. Xin-Feng Luo, Ling He*, Hai-Bin Yin, Hu Zheng, Di Bei, Jin-Jin Deng, Wen-Cai Huangc*. Efficient Acylation and One-Pot Synthesis of Dehydroandrographolide Succinate on a Large Scale Assisted with Microwave Radiation. Synthetic Communications, 2009，in press. 12. Zhi Yu Liu*, Ling He, Hu Zheng. Highly Enantioselective synthesis of (+) and (-) Endo-Tricyclo[5,2,1,02,6] Deca-4,8-dien-3-one and (-)-4-t-Butyldimethyl silyloxycyclopentenone by Enzyme-catalyzed Acetylation. Tetrahedron: Asymmetry 1993, 4, 2277-2278. 13. Zhi Yu Liu*, Ling He, Hu Zheng. Natural Products Synthesis by Retro Diels-Alder Reactions IV: Total Synthesis of invictolide and 6-Epiinvictolide. SYNLETT , 1993, 191-192. 14. W.David Nes*, Ling He, Anil T. Mangla. 4,4,14α-Trimethyl 9β,19-cyclo-5α-26-Homoch- olesta-24,26-Dien-3β-ol:A Potent Mechanism-Based Inactivator of △24(25) To △25(27) Sterol Methyl Tran- sferase. Bioorganic & Medicinal Chemistry Letters 1998, 8, 3449-3452. 15. Xiaohong Ou, Tianzhi Tan, Ling He, Yunchun Li,Julian Li,Anren Kuang. Antitumor effects of radioiodinated antisense oligonuclide mediated by VIP receptor. Cancer gene therapy 2005, 12(3), 313-20. 16. Yue Chen*, Zhan Wen Huang, Ling He, Shi Long Zheng, Ju Lian Li, Da Lian Qin. Synthesis and evaluation of a technetium-99m-labeled diethylene triaminepentaacetate- deoxyglucose complex ([99mTc]-DTPA-DG) as a potential imaging modality for tumors. Applied Radiation and Isotopes 2006, 64(3), 342-347. 17. Yue Chen*, Zhan Wen Huang, Ling He, Ju Lian Li, Da Lian Qin. Synthesis and Characterization of 99mTc-DTPA-DG for Tumor Detection. European Journal of Nuclear Medicine and Molecular Imaging 2005, Vol.32.771. 18. Zhi Yu Liu*,Xin Jie Chu, Ling He, Yi Long Xie, Natural Products Synthesis by Retro Diels-Alder Reaction (Review), Organic Chemistry, 1997,17(1), 62-65. 19. W. David Nes*,Julie A.Marshall,Wen Zhou, Ling He, Allen L. Dennis. Mechanism-Based Active Site Modification of Sterol Methyl Transferase by Tritium-Labeled 26-Homocholesta-8,14,24-Trien-26-yn-3β-ol. Tetrahedron letters, 1998, 39: 8575~8578. 20. W.David Nes*,Brian S. McCourt,Julie A. Marshall,Jian Zhong Ma,Allen L. Dennis,Monica Lopez,Hao Xia Li, Ling He. Site-Directed Mutagenesis of Sterol Methyl Transferase Active Site From Saccharomyces Cersvisiae Results in Formation of Novel-Ethyl Sterols. J.Org.Chem. 1999, 64(5), 1535-1542.