郭丽 - 四川大学 - 华西药学院

个人简介

1983年毕业于四川医学院药物化学专业, 获学士学位；1990年毕业于华西医科大学药物化学专业, 获理学硕士学位；1994年毕业于华西医科大学药物化学专业, 获理学博士学位；1995年在四川大学化工学院晋升副教授；2000-2001 德国Tuebingen大学有机化学研究所,博士后工作；2003年在四川大学华西药学院晋升教授, 2004年聘为博士生导师；2007～至今华西药学院药物化学系主任。四川省学术和技术带头人后备人选，四川省卫生厅学术和技术带头人，四川大学教学名师培养对象。国家科技奖励评审专家，国家自然科学基金同行评审专家等。

研究领域

1．靶向药物及聚集型多肽药物的研究 2．树枝状化合物在药物研究中的应用

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Novel Dendritic Naproxen Prodrugs with Poly(aspartic acid) Oligopeptide: Synthesis and Hydroxyapatite Binding In Vitro, Synthetic Communications,2012,42,3441-3451 2.Synthesis and preliminary evaluation of novel amphiphilic Janus dendrimers for bone-targeted drug delivery，Tetrahedron,2012,68,2943-2949 3.Synthesis, antibacterial activity and cytotoxicity of novel Janus peptide dendrimers, synlett，2012, 23,1937-1940 4.Dual-targeting delivery system for bone cancer: synthesis and preliminary biological evaluation, Drug Delivery，2012,19(7),317-326 5.Design and synthesis of novel Janus dendrimers as lipophilized antioxidants，synlett. 2013,24(8), 1011-1015 6.Dual-targeting Janus dendrimer based peptides for bone cancer: synthesis and preliminary biological evaluation, Letters in Organic Chemistry，2013,10(8),594-601 7.Design, synthesis and biological evaluation of enzymatically cleavable NSAIDs prodrugs derived from self-immolative dendritic scaffolds for the treatment of inflammatory diseases，Bioorganic Medicinal Chemistry，2013,21(14),4192-4200 8.Molecular Docking, QSAR and Molecular Dynamics Simulation on Spiro-oxindoles as MDM2 Inhibitors，Acta Chimica Sinica，2013,71,1396-1403 9.Multicomplex-Based Pharmacophore and QSAR of Aryl-sulfamides as Pyruvate Kinase M2 Activators, Acta Physico-Chimica Sinica,2013.29,1793-1803 10.Synthesis of cis or trans 4-heteroaromatic substituted furano and pyrano[3,2-c] tetra- hydroquinolines by onepot imino diels-alder reactions, Heterocycles, 2013, 87(12),2495- 2500 11.Synthesis and Intestinal Absorption Evaluation Of oligopeptide Prodrugs Based On PepT1, West China J.Pharm.Sci., 2013,28(3),223-225 12.Preparation and Characterization of Glycyrrhetinic Acid-Modified Poloxamer 188/Chitosan Nanoparticles. NANO: Brief Reports and Reviews, 2013, 8(4), 1350042-1-8 13.Cell-penetrable lysine dendrimers for anti-cancer drug delivery: synthesis and preliminary biological evaluation，Archiv der Pharmazie, 2014, 347, 469-477 14.Dimer and Tetramer of Gallic Acid: Facile Synthesis, Antioxidant and Antiproliferative Activities，Letters in Drug Design & Discovery, 2014, 11, 27-32 15.Diastereoselective，Three-component ，Reaction of Chiral Nickel(II)， Glycinate for Convenient Synthesis of Novel α-amino-β-substituted-γ,γ-disubstituted butyric Acid, Molecules,2014,19,826-845 16.Discovery and in Vivo Evaluation of Novel RGD-Modified Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery, Int. J. Mol. Sci., 2014,15, 17565-17576 17.Design, synthesis and biological evaluation of brain targeting L-ascorbic acid prodrugs of ibuprofen with “lock-in” function, European Journal of Medicinal Chemistry, 2014,82,314-323 18.Efficient Synthesis of Substances Related to Cinacalcet Hydrochloride via Heck Coupling，Synthetic Communications，2014，44，2879-2885 19.A novel and convenient route for the construction of 5-((1H-1,2,4-triazol-1-yl)methyl) -1H-indoles and its application in the synthesis of Rizatriptan, Tetrahedron Letters, 2014,55,3938-3941 20.Preparation and characterization of glycyrrhetinic acid-modified poly(ethylene glycol)-poly(β-benzyl-L-asparate) nanoparticles as liver- targeted delivery system, Colloid Polym Sci. ,2015,293,319-328