马志强 - 华南理工大学 - 化学与化工学院

个人简介

Working experience 2016-Present Professor of School of Chemistry and Chemical Engineering, South China University of Technology 2007-2015 Postdoctoral fellow with Prof. Chuo Chen at UT Southwestern Medical Center Education 2001-2007 Ph.D. in Shanghai Institute of organic chemistry, Chinese Academy of Sciences，advisor Hongbin Zhai (翟宏斌) 1997-2001 B.S.in Lanzhou University/College of Chemistry

研究领域

We are interested in natural product synthesis, target-oriented methodology development and medicinal chemistry. In particular, we are working on biologically active alkaloids and terpenes containing quaternary carbon centers. We seek to apply cycloaddition, radical cyclization, and developed cascade reactions to rapidly assemble structurally challenging architectures. We have completed asymmetric synthesis of ergostane-type steroids dankasterones A and B and periconiastone A, divergent synthesis of skeletally distinct Monoterpenoid indole alkaloids arboridinine and arborisidine , and 14-step synthesis of Myrioneuron alkaloid myrioneurinol.

近期论文

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Asymmetric Synthesis of ArboduridineYang, R.†; Zhou, Z.†; Jiang, H.;Kam,T.-S.; Chen, K.; Ma, Z.*(†equal contribution)Angew. Chem. Int. Ed. 2023, 61,e202316016. Formal Total Synthesis of Dankasterone BDeng, S.; Xu, H.; Jiang, H.;Ma, Z.*Org. Chem.Front., 2022, 9,3961. Formal Synthesis of Arboridinine Enabled by a Double-Mannich ReactionWu, J.; Jiang, H.;Ma, Z.*J. Org. Chem. 2022, 87, 8223. ConciseSynthesis of (±)-Myrioneurinol Enabled by Sequential[2+2]Cycloaddition/Retro-Mannich Fragmentation/Mannich ReactionZhang, N.; Jiang, H.;Ma, Z.*Angew. Chem. Int. Ed. 2022, 61,e202200085. Divergent Synthesis of Skeletally Distinct Arboridinine and Arborisidine Wang, C.†;PangY.†;Wu,Y.; Zhang,N.;Yang,R.;Li,Y.;Chen,P.;Jiang,H.;Xu,X.-T.;Kam,T.-S.;Fan,T.;Ma, Z.*(†equal contribution)Angew. Chem. Int. Ed. 2021, 60, 26978. Asymmetric Total Synthesis of Dankasterones A and B and Periconiastone A Through Radical CyclizationChen, P.†;Wang, C.†;Yang, R.;Xu, H.;Wu, J.;Jiang, H.;Chen, Kai.; Ma, Z.*Angew. Chem. Int. Ed.2021, 60, 5512. Metal-hydride hydrogen atom transfer (MHAT) reactions in natural product synthesis Wu, J.; Ma, Z.*Org. Chem.Front., 2021, 8,7050. Synthetic Progress of Natural Products Gracilioethers and Hippolachnin AWu, J.; Wang, C.; Chen, P.; Ma, Z.* Chin. J. Org. Chem. 2020, 40, 3289. Ir-Catalyzed Reactions in Natural Product Synthesis Chen, P.;Wu,Y.; Zhu,S.;Jiang,H.;Ma, Z.*Org. Chem. Front., 2018, 5, 132. Palladium-Catalyzed Intermolecular Oxidative Cyclization of Allyltosylamides with AcOH: Assembly of 3 Pyrrolin-2-onesHuang,J.;Zheng,J.;Wu,W.;Li,J.;Ma, Z.*; Ren,Y.;Jiang,H.* J. Org. Chem. 2017, 82, 8191. Natural Products as Inspiration for the Development of New Synthetic Methods Ma, Z.; Chen, C.*J. Chin. Chem. Soc.2018, 1, 43. Stereocontrolled Formation of a [4.4]Heterospiro Ring System with Unexpected Inversion of Configuration at the SpirocenterMa, Z.; You, L.; Chen, C.*J. Org. Chem.2017, 82, 731. Asymmetric Synthesis of Axinellamines A and BMa, Z.; Wang,X.;Ma,Y.;Chen,C.* Angew. Chem. Int. Ed. 2016, 55, 4763. Asymmetric Syntheses of Sceptrin and Massadine and Evidence for Biosynthetic EnantiodivergenceMa, Z.†; Wang,X.†;Wang,X.;Rodrigo,A.;Rodriguez, C.;Moore.;Gao,S.;Tan,X.;Ma,Y.;Rheingold,A.;Baran,P.;Chen, Chuo.* (†equal contribution)Science2014, 346, 219. Synthetic Studies toward HarringtonolideMa, Z.; Cheng,B.;Zhai, H.*Asian J. Org. Chem.2014, 3, 1097. Dimeric pyrrole-imidazole alkaloids: Synthetic approaches and biosynthetic hypothesesWang, X.; Ma, Z.;Wang, X.; De, S.; Ma,Y.;Chen, C.*Chem. Commun.2014, 50, 8628. Asymmetric Synthesis of AgeliferinWang,X.;Ma, Z.;Lu, J.;Tan,X.;Chen, Chuo.*J. Am. Chem. Soc. 2011, 133, 15350. Revisiting the Kinnel−Scheuer hypothesis for the biosynthesis of palau'amine Ma, Z.;Lu, J.;Wang, X;.Chen,Chuo.*Chem. Commun.2011, 47, 427. Structure/Activity Relationship Studies of Small-Molecule Inhibitors of Wnt Response Lu, J.; Ma, Z.;Hsieh, J.; Fan, C.; Chen, B.; Longgood, J.; Williams, N.; Amatruda, J.; Lum, L.; Chen,Chuo.*Bioorg. Med. Chem. Lett.2009, 19, 3825. Concise Formal Syntheses of (-)-Aphanorphine and Unnatural (+)-Aphanorphine from (2S,4R)-4-HydroxyprolineMa, Z.;Hu, H.; Xiong,W.; Zhai, H.* Tetrahedron2007, 63,7523. Concise Formal Synthesis of Unnatural (+)-Aphanorphine from (2S,4R)-4-HydroxyprolineMa, Z.;Zhai, H.*Synlett 2007, 161