个人简介
Professional Experience
2019.04-Present Tenure-Track Assistant Professor, School of Pharmaceutical Sciences, Peking University Principal Investigator, State Key Laboratory of Natural and Biomimetic Drugs
2016-2019 Postdoc in Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany (Advisor: Professor Herbert Waldmann)
2009-2011 Research Assistant in Chemistry Center, National Institute of Biological Sciences, Beijing, China (Advisor: Professor Xiaoguang Lei)
Education
2011-2016 Ph.D. in Organic Chemistry, University of Geneva, Geneva, Switzerland (Advisor: Professor Clément Mazet)
2006-2009 M.S. in Chemical Biology, Peking University, Beijing, China (Advisor: Professor Xin-Shan Ye)
2002-2006 B.S. in Pharmaceutical Sciences, Peking University, Beijing, China
Awards
2022 Thieme Chemistry Journals Award
2016-2018 Swiss National Science Foundation (SNSF) Early Postdoc. Mobility fellowship
2016 The Reaxys PhD Prize Shortlist
2013 Travel Award from the Schmidheiny Foundation
近期论文
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Enantioselective Synthesis of Five-Membered-Ring Atropisomers with a Chiral Rh(III) Complex Saad Shaaban, Houhua Li, Felix Otte, Carsten Strohmann, Andrey P. Antonchick*, and Herbert Waldmann*, Org. Lett. 2020, 22, 9199-9202.
Syntheses of Skeletally Diverse Tetracyclic Isodon Diterpenoid Scaffolds Guided by Dienyne...Weilong Liu, Zongwei Yue, Zhen Wang, Houhua Li, Xiaoguang Lei* Org. Lett. 2020, 22, 7991-7996.
Enantioselective Formal C(sp3)−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone..Houhua Li, Rajesh Gontla, Jana Flegel, Christian Merten, Slava Ziegler, Andrey P. Antonchick,* Herbert Waldmann* Angew. Chem. Int. Ed. 2019, 58, 307-311.
C−H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway..Gang Shan, Jana Flegel, Houhua Li, Christian Merten, Slava Ziegler, Andrey P. Antonchick,* Herbert Waldmann* Angew. Chem. Int. Ed. 2018, 57, 14250-14254.
ent-Jungermannenone C Triggers Reactive Oxygen Species-Dependent Cell Differentiation...Zongwei Yue, Xinhua Xiao, Jinbao Wu, Xiaozhou Zhou, Weilong Liu, Yaxi Liu, Houhua Li, Guoqiang Chen, Yingli Wu,* Xiaoguang Lei* J. Nat. Prod. 2018, 81, 298-306.
Fawcettimine-Type Lycopodium Alkaloids as a Driving Force for Discoveries in Organic Synthesis Houhua Li, Xiaoguang Lei* Chem. Rec. 2018, 18, 543-554.
Divergent Total Syntheses of (−)-Huperzine Q, (+)-Lycopladine B, (+)-Lycopladine C, and...Benke Hong, Dachao Hu, Jinbao Wu, Jing Zhang, Houhua Li, Yingming Pan, Xiaoguang Lei* Chem. Asian J. 2017, 12, 1557-1567 (Selected as a Very Important Paper).
Exploring Site Selectivity of Iridium Hydride Insertion into Allylic Alcohols: Serendipitous...Houhua Li†, Daniele Fiorito†(†co-first author), Clément Mazet* ACS Catal. 2017, 7, 1554-1562.
Iridium-Catalyzed Selective Isomerization of Primary Allylic Alcohols Houhua Li, Clément Mazet* Acc. Chem. Res. 2016, 49, 1232-1241.
Scalable Total Synthesis of rac-Jungermannenones B and C Weilong Liu†, Houhua Li†(†co-first author), Peijun Cai, Zhen Wang, Zhi-Xiang Yu, Xiaoguang Lei* Angew. Chem. Int. Ed. 2016, 55, 3112-3116 (Highlighted in Synfacts 2016, 12, 332).
Pd2Au36(SR)24 cluster: structure studies† B. Zhang, S. Kaziz, H. Li, D. Wodka, S. Malola, O. Safonova, M. Nachtegaal, C. Mazet, I. Dolamic, J. Llorca, E. Kalenius, L. M. L. Daku, H. Hakkinen, T. Bürgi,* N. Barrabés* Nanoscale 2015, 7, 17.
Enantioselective Total Synthesis of (−)-Incarviatone A B. Hong, C. Li, Z. Wang, J. Chen, H. Li,* X. Lei* J. Am. Chem. Soc. 2015, 137, 11946-11949.
Catalyst-Directed Diastereoselective Isomerization of Allylic Alcohols for the Stereoselective..Houhua Li, Clément Mazet* J. Am. Chem. Soc. 2015, 137, 10720-10727 (Highlighted in Synform 2016, A21-A24).
Modulation of Active Sites in Supported Au38(SC2H4Ph)24 Cluster Catalysts:...Bei Zhang, Sameh Kaziz, Houhua Li, Miguel González Hevia, Dawid Wodka, Clément Mazet, Thomas Bürgi,* Noelia Barrabés*, J. Phys. Chem. C 2015, 119, 11193-11199.
Total Syntheses of (−)-Huperzine Q and (+)-Lycopladines B and C Benke Hong†, Houhua Li†(†co-first author), Jinbao Wu, Jing Zhang, Xiaoguang Lei* Angew. Chem. Int. Ed. 2015, 54, 1011-1015.
Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group...Jing Zhang, Jinbao Wu, Benke Hong, Wenying Ai, Xiaoming Wang, Houhua Li, Xiaoguang Lei*,Nat. Commun. 2014, 5, 4614.
Well-defined transition metal hydrides in catalytic isomerizations Evgeny Larionov, Houhua Li, Clément Mazet* Chem. Commun. 2014, 50, 9816-9826.
Steric Parameters in the Ir-Catalyzed Regio- and Diastereoselective Isomerization of Primary...Houhua Li, Clément Mazet* Org. Lett. 2013, 15, 6170-6173.
Challenges and Strategies to the Total Syntheses of Fawcettimine-Type and Serratinine-Type...Xiaoming Wang, Houhua Li, Xiaoguang Lei* Synlett 2013, 24, 1032-1043 (Invited Synpacts Article).
Collective Synthesis of Lycopodium Alkaloids and Tautomer Locking Strategy for the Total...Houhua Li†, Xiaoming Wang†(†co-first author), Benke Hong, Xiaoguang Lei* J. Org. Chem. 2013, 78, 800-821 (Selected as the Featured and Cover Article).
Selective Alkene Metathesis in the Total Synthesis of Complex Natural Product Xiaogaung Lei*, Houhua Li Stereoselective Alkene Synthesis (Ed. Jianbo Wang), Top. Curr. Chem. Springer-Verlag, Heidelberg, 2012, 327, 163-196.
Total Syntheses of Lycopodium Alkaloids (+)-Fawcettimine, (+)-Fawcettidine, and...i Houhua Li, Xiaoming Wang, Xiaoguang Lei* Angew. Chem. Int. Ed. 2012, 51, 491-495 (Highlighted in Chin. J. Org. Chem. 2012, 32, 639).
Efficient Generation of ortho-Quinone Methide: Application to the Biomimetic Syntheses of ...f Daohong Liao, Houhua Li, Xiaoguang Lei* Org. Lett. 2012, 14, 18-21.
Regio- and stereo-selective synthesis of aryl 2-deoxy-C-glycopyranosides by palladium-catalyzed...Hou-Hua Li, Xin-Shan Ye* Org. Biomol. Chem. 2009, 7, 3855-3861.
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