李祥 - 香港大学

个人简介

Honors and Awards NSFC Excellent Young Scientists Award (Hong Kong and Macau), 2019 CAPA Distinguished Faculty Award from Chinese-American Chemistry & Chemical Biology Professors Association (CAPA), USA, 2018 The Distinguished Lectureship Award from The Chemical Society of Japan, 2018 Outstanding Young Researcher Award 2015/16, The University of Hong Kong 2016 Early Career Award from the Hong Kong Research Grant Council (RGC), 2013 Li Ka Shing Prize at The University of Hong Kong, 2009. C. H. Li Memorial Scholar Fund Postdoctoral Fellowship at The Rockefeller University, 2008. Roche Creative Chemistry Award at Roche R&D center in Shanghai, 2007. Best Poster Presentation Award in the MGH-HKU-Nature China Forum, 2007. Best Oral Presentation Award in The Twelfth Symposium on Chemistry Postgraduate Research in Hong Kong, 2005. Outstanding Graduate Student Award at Fudan University, 2003. First Prize of Kodak Scholarship at Fudan University, 2002. First Prize of National Chemistry Olympic Contest, 1999.

研究领域

1. Chemical Epigenetics: To explore the biological significance of novel histone PTMs. i. To identify the ‘readers’ and regulating enzymes of histone PTMs. ii. To study the effects of histone PTMs on chromatin compaction. 2. To develop new tools for studying protein-protein interactions. 3. To develop chemical reporters for PTMs.

近期论文

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Jing Y, Ding D, Tian G, Kwan K C J, Liu Z, Ishibashi T, Li XD, Semisynthesis of site-specifically succinylated histone reveals that succinylation regulates nucleosome unwrapping rate and DNA accessibility, Nucleic Acids Research, doi.org/10.1093/nar/gkaa663. Wang J, Xiong Z, Liu M, Li XM, Zheng J, Zhan X, Ding W, Chen J, Li X, Li XD, Tang J, Rational Design of Reversible Redox Shuttle for Highly Efficient Light-Driven Microswimmer, ACS Nano 2020, 14, 3, 3272–3280 Bao X, Liu Z, Zhang W, Gladysz K, Fung YME, Tian G, Xiong Y, Wong JWH, Yuen KWY, Li XD.Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics. Mol Cell. 2019 Nov 21;76(4):660-675.e9. Li X, Wu Y, Tian G, Jiang Y, Liu Z, Meng X, Bao X, Feng L, Sun H, Deng H, Li XD. Chemical Proteomic Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells. J. Am. Chem. Soc., 2019, 141(29), 11497-11505. Miao R, Lung SC, Li X, Li XD, Chye ML. Thermodynamic insights into an interaction between ACYL-COA-BINDING PROTEIN2 and LYSOPHOSPHOLIPASE2 in Arabidopsis. J. Biol. Chem., 2019, doi: 10.1074/jbc. Zhou Y, Li C, Peng J, Xie L, Meng L, Li Q, Zhang J, Li XD, Li X, Huang X, Li X. DNA-Encoded Dynamic Chemical Library and Its Applications in Ligand Discovery. J. Am. Chem. Soc., 2018, 140(46), 15859-15867. Li X, Li XM, Jiang Y, Liu Z, Cui Y, Fung KY, van der Beelen SHE, Tian G, Wan L, Shi X, Allis CD, Li H, Li Y, Li XD. Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking. Nat. Chem. Biol., 2018, 14, 1140-1149. Bao X, Xiong Y, Li X, Li XD. A chemical reporter facilitates the detection and identification of lysine HMGylation on histones. Chem. Sci., 2018, 9, 7797-7801. Jing Y, Liu Z, Tian G, Bao X, Ishibashi T, Li XD. Site-Specific Installation of Succinyl Lysine Analog into Histones Reveals the Effect of H2BK34 Succinylation on Nucleosome Dynamics. Cell Chem. Biol., 2018, 25(2), 166-174. Andolina G, Wei R, Liu H, Zhang Q, Yang X, Cao H, Chen S, Yan A, Li XD, Li X. Metabolic Labeling of Pseudaminic Acid-Containing Glycans on Bacterial Surfaces. ACS Chem. Biol., 2018, 13(10), 3030-3037. Li XM, Li XD. Interrogating Interactions and Modifications of Histones in Live Cells. Cell Chem. Biol., 2018,18;25(1):1-3. Lin J, Li XD. Peptide-based approaches to identify and characterize proteins that recognize histone post-translational modifications. Chin. Chem. Lett. 2018, 29(07), 1051-1057. Chen Y, Li TL, Lin X, Li X, Li XD, Guo Z. Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate-binding mode. J. Biol. Chem., 2017, 292, 12296-12310. Xie X, Li XM, Qin F, Lin J, Zhang G, Zhao J, Bao X, Zhu R, Song H, Li XD, Chen PR. Genetically Encoded Photoaffinity Histone Marks. J. Am. Chem. Soc., 2017, 139, 6522–6525. Cui Y, Li X, Lin J, Hao Q, Li XD. Histone Ketoamide Adduction by 4-Oxo-2-nonenal Is a Reversible Posttranslational Modification Regulated by Sirt2. ACS Chem. Biol., 2017, 12, 47-51. Yang T, Li XM, Bao X, Fung YME, Li XD. Photo-lysine Captures Proteins that Bind Lysine Post-translational Modifications. Nat. Chem. Biol., 2016, 12, 70-72. Yang T, Liu Z, Li XD. Developing Diazirine-based Chemical Probes to Identify Histone Modification ‘Readers’ and ‘Erasers’. Chem. Sci., 2015, 6, 1011-1017. Liu Z, Yang T, Li X, Peng T, Hang HC, Li XD. Integrative Chemical Biology Approaches for Identification and Characterization of “Erasers” for Fatty-Acid-Acylated Lysine Residues within Proteins. Angew. Chem. Int. Edit., 2015, 54, 1149-1152. Li X; Li XD. Chemical proteomics approaches to examine novel histone posttranslational modifications. Curr. Opin. Chem. Biol., 2015, 24, 80-90. Bao X, Wang Y, Li X, Li XM, Yang T, Wong CF, Zhang J, Hao Q, Li XD. Identification of ‘Erasers’ for Lysine Crotonylated Histone Marks Using a Chemical Proteomics Approach. eLife. 2014, 3, e02999.