黄重行 - 香港大学

个人简介

Zhongxing was born and raised in Shanghai, China. He obtained his B.Sc. degree from Peking University in 2012 under the supervision of Professor Jianbo Wang and Yan Zhang. He conducted his graduate study in the laboratory of Professor Guangbin Dong at the University of Texas, Austin (2012-2016), and University of Chicago (2016-2017). His research in the Dong group focused on the development of a new palladium-catalyzed redox cascade for the direct β-functionalization of ketones. Upon the completion of his Ph.D. thesis, he joined the laboratory of Professor Barry M. Trost at Stanford University as a postdoctoral fellow and studied the cycloaddition reactions involving Pd-heteroallyl intermediates. August 2019 Assistant Professor, Department of Chemistry, University of Hong Kong 2017 - 2019 Postdoctoral Fellow, Department of Chemistry, Stanford University 2016 - 2017 Ph.D. University of Chicago 2012 - 2016 Research Assistant, Department of Chemistry,University of Texas at Austin 2008 - 2012 B.Sc. Peking University

研究领域

Research efforts in our laboratory will be dedicated to developing new and innovative organic transformations that address challenges in organic synthesis and have broad implications in multiple areas, including environmental and medicinal chemistry. Design of novel catalysts that enable efficient and sustainable catalysis will be the center of our research program. Major research topics include: (a) Development of new strategies or paradigms of catalysis for enantioselective synthesis of bioactive molecules and useful synthetic building blocks. (b) Identifying new transition metal or main group catalysts to enable efficient bond forming reactions that avoid the generation of hazardous waste. (c) Catalytic and chemoselective conversion of biomass derivatives to fine chemicals with high atom economy.

近期论文

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Cobalt-Catalyzed Desymmetrization of Malononitriles via Enantioselective Borohydride Reduction Zheng, Yin;^ Yang, T.;^ Chan, K. F.; Lin, Z.*; Huang, Z.*, Nat. Chem. 2024, 16 Modular and Diverse Synthesis of Amino Acids via Asymmetric Decarboxylative Protonation of Aminomalonic Acids Zheng, Wei-Feng; Chen, J. (UG); Qi, X.*; Huang, Z.*, Nat. Chem. 2023. Zinc-Catalyzed Desymmetric Hydrosilylation of Monosubstituted Malonic Esters Zhang, Yixiao; Xu, P.; Zhao, Q.; Wang, J. ; Huang, Z.*, Org. Chem. Front. 2023, 10, 1675. Diverse Synthesis of α-Tertiary Amines and Tertiary Alcohols via Desymmetric Reduction of Malonic Esters Liu, Haichao; Lau, H. M.; Xu, P.; Chan, T. H. (UG); Huang, Z.*, Nat. Commun. 2022, 13, 4759. Desymmetric Cyanosilylation of Acyclic 1,3-Diketones Xu, Pan; Shen, C.; Xu, A.; Low, K.-H.; Huang, Z.*, Angew. Chem. Int. Ed. 2022, 61. e202208443. Desymmetric Partial Reduction of Malonic EstersXu, Pengwei; Liu, S.; Huang, Z.*, J. Am. Chem. Soc. 2022, 144, 6918-6927. A Unified and Desymmetric Approach to Chiral Tertiary Alkyl Halides Zheng, Yin; Zhang, S. (UG); Low, K.-H.; Zi, W.; Huang, Z.*, J. Am. Chem. Soc. 2022, 144, 1951-1961. Sewing Molecules Together with Light Xu, Pan; Huang, Z.*, Trends Chem. 2022, 4, 169-171 Catalytic Reductive Desymmetrization of Malonic Esters Xu, Pengwei; Huang, Z.*, Nat. Chem. 2021, 13, 634-642. Selected Publications before HKU Total Synthesis of Bryostatin 3 Trost, B. M.*; Wang, Y.; Buckl, A. K.; Huang, Z.; Nguyen, M. H.; Kuzmina, O., Science 2020, 368, 1007. Catalytic (3+2) Palladium‐Aminoallyl Cycloaddition with Conjugated Dienes Trost, B. M.; Huang, Z., Angew. Chem. Int. Ed. 2019, early view. [Link] Catalytic Palladium-Oxyallyl Cycloaddition Trost, B. M.; Huang, Z.; Murhade, G. M., Science 2018, 362, 564. Palladium-Catalyzed Redox Cascade for Direct β-Arylation of Ketones Huang, Z.; Dong, G., Tetrahedron 2018, 74, 3253. Site-Selectivity Control in Organic Reactions: A Quest to Differentiate Reactivity among the Same Kind of Functional Groups Huang, Z.; Dong, G., Acc. Chem. Res. 2017, 50, 465. A Hydrazone-Based Directing Group Strategy for β-C−H Oxidation of Aliphatic Amines Huang, Z.; Wang, C.; Dong, G., Angew. Chem. Int. Ed. 2016, 55, 5209. Transition Metal-Catalyzed Ketone-Directed or Mediated C−H Functionalization Huang, Z.; Lim, H. N.; Mo, F.; Young, M.; Dong, G., Chem. Soc. Rev. 2015, 44, 7764. Palladium-Catalyzed Direct β-Arylation of Ketones with Diaryliodonium Salts: a Stoichiometric Heavy Metal-Free and User-Friendly Approach Huang, Z.; Sam, Q. P.; Dong, G., Chem. Sci. 2015, 6, 5491. Catalytic C−C Bond Forming Transformations via Direct β-C−H Functionalization of Carbonyl Compounds Huang, Z.; Dong, G., Tetrahedron Lett. 2014, 55, 5869. Catalytic Direct β-Arylation of Simple Ketones with Aryl Iodides Huang, Z.; Dong, G., J. Am. Chem. Soc. 2013, 135, 17747. Auto-Tandem Catalysis: Synthesis of Acridines by Pd-Catalyzed C=C Bond Formation and C(sp2)−N Cross-Coupling Huang, Z.; Yang, Y.; Xiao, Q.; Zhang, Y.; Wang, J., Eur. J. Org. Chem. 2012, 6586.