何健 - 香港大学

个人简介

EDUCATION California Institute of Technology Postdoctoral Fellow (2016–2019)Advisor: J. C. Peters The Scripps Research Institute Ph.D. in Chemistry (2011–2016)Advisor: J.-Q. Yu Zhejiang University B.S. in Chemistry (2007–2011)Advisor: S. Ma BIOSKETCH Jian received his B.Sc. degree in Chemistry with highest honors from Zhejiang University, where he conducted research under the direction of Prof. Shengming Ma. In 2011, he moved to the Scripps Research Institute to pursue his graduate studies under the supervision of Prof. Jin-Quan Yu. After completing a two-year appointment as a Postdoctoral Fellow with Prof. Jonas C. Peters at Caltech, Jian joined the faculty at The University of Hong Kong in August of 2019. His research interests lie at the interface of organometallic chemistry, organic synthesis, catalysis, synthetic biology, and materials science. Outside of the lab, Jian enjoys eating delicious food, watching movies, and travelling with his wife and parents.

研究领域

The development of heterogeneous catalysts with high activity, selectivity, and stability is essential for rendering catalytic organic reactions practically useful, since they provide highly recyclable, scalable, and efficient setups in many large-scale chemical processes. Additionally, these catalysts may be utilized in continuous flow systems, which facilitates facile automation and improves product quality through easy separation. While numerous organic transformations have been achieved in homogeneous catalytic systems, the needs for addressing their synthetic limitations, such as high catalyst loadings, poor selectivity, and employment of toxic and expensive reagents, represent challenges and opportunities for the coming generation of chemists. Designing novel catalysts that marry the benefits of heterogeneous catalysis with those of homogeneous catalysis to solve the long-standing problems in organic synthesis is compelling and highly desirable.

近期论文

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Wen, S.; Zhang, C.; Liu, L.-J.; Wang, Z.; Sun, D.;* He, J.* Stable and Recyclable Copper Nanoclusters with Exposed Active Sites for Broad-Scope Protosilylation in Open Air. Angew. Chem. Int. Ed. 2024, 63, e202416851. Sun, M.-Y.; Cheung, S. C.; Wang, X.-Z.; Jin, J.-K.; Guo, J.; Li, D.;* He, J.* Structural Reassignment of Covalent Organic Framework-Supported Palladium Species: Heterogenized Palladacycles as Efficient Catalysts for Sustainable C–H Activation. ACS Cent. Sci. 2024, 10, 1848−1860. This cover depicts that palladacycle complexes embedded in two-dimensional covalent organic framework supports promote C2-selective C–H arylation of indole and pyrrole derivatives with diaryliodonium salts. Ahmad, M.; Nawaz, T.; Eddahani, Y.; Hussain, I.;* Chen, X.; Low, K. H.; He, J.;* Zhang, K.* Strategic Fabrication of Au4Cu2 NC/ZIF-8 Composite Via In Situ Integration Technique for Enhanced Energy Storage Applications. Adv. Funct. Mater. 2024, 2407059. Liu, L.-J.; Zhang M.-M.; Deng, Z.; Yan, L.-L.; Lin, Y.; Phillips, D. L.; Yam, V. W.-W.; He, J.* NIR-II Emissive Anionic Copper Nanoclusters with Intrinsic Photoredox Activity in Single-Electron Transfer. Nat. Commun. 2024, 15, 4688. Du, X.; Zhang, Y.; Yang, T.;* Xiao, Y.; He, J.; Chung, L. W.; Chen, G.-Q.;* Zhang, X.* A Versatile Cobalt Catalyst for Highly Enantioselective Hydrogenation of Carbonyl Compounds. Chem Catal. 2024, 4, 100999. Guo, J.; Xia, Q.; Tang, W. Y.; Li, Z.; Wu, X.; Liu, L.-J.; To, W.-P.; Shu, H.-X.; Low, K.-H.; Chow, P. C. Y.; Lo, T. W. B.; He, J.* Visible Light-Mediated Intermolecular Crossed [2+2] Cycloadditions Using a MOF-Supported Copper Triplet Photosensitizer. Nat. Catal. 2024, 7, 307–320. Zhou, Y.; Gu, W.; Wang, R.; Zhu, W.; Hu, Z.; Fei, W.; Zhuang, S.; Li, J.; Deng, H.; Xia, N.;* He, J.;* Wu, Z.* Controlled Sequential Doping of Metal Nanocluster. Nano Lett. 2024, 24, 2226–2233. Wang, J.; Shen, X.; Chen, X.; Bao, Y.; He, J.; Lu, Z.* Cobalt-Catalyzed Enantioconvergent Negishi Cross-Coupling of α-Bromoketones. J. Am. Chem. Soc. 2023, 145, 24958–24964. Zhuang, S.-L.; Chen, D.; Ng, W.-P.; Liu, L.-J.; Sun, M.-Y.; Liu, D.; Nawaz, T.; Xia, Q.; Wu, X.; Huang, Y.-L.; Lee, S.; Yang, J.;* Yang, J.;* He, J.* Phosphine-Triggered Structural Defects in Au44 Homologues Boost Electrocatalytic CO2 Reduction. Angew. Chem. Int. Ed. 2023, 62, e202306696. Nawaz, T.; Ahmad, M.; Ansari, M. Z.; Hussain, I.; Chen, X.; Liu, L.-J.; Walia, R.; Low, K.-H.; Zhuang, S.-L.; Zhang, K.;* He, J.* Structural Study of Atomically Precise Doped Au38−xAgx NCs@ZIF-8 Electrode Material for Energy Storage Application. Chem. Eng. J. 2023, 468, 143575. Liu, L.-J.; Alkan, F.; Zhuang, S.-L.; Liu, D.; Nawaz, T.; Guo, J.; Luo, X.; He, J.* Atomically Precise Gold Nanoclusters at the Molecular-to-Metallic Transition with Intrinsic Chirality from Surface Layers. Nat. Commun. 2023, 14, 2397. Ma, B.; Xia, Q.; Wang, D.; Jin, J.-K.; Li, Z.; Liang, Q.-J.; Sun, M.-Y.; Liu, D.; Liu, L.-J.; Shu, H.-X.; Yang, J.; Li, D.;* He, J.* Metal–Organic Framework Supported Copper Photoredox Catalysts for Iminyl Radical-Mediated Reactions. Angew. Chem. Int. Ed. 2023, e202300233. Zhu, W.; Zhang, S.; Fan, W.; Yang, Y.; Zhao, H.; Fei, W.; Bi, H.; He, J.; Li, M.-B.;* Wu, Z.* Atomically Precise Metal Nanoclusters as Single Electron Transferers for Hydroborylation. Precis. Chem. DOI: 10.1021/prechem.3c00003. Zhuang, S.-L.; Chen, D.; NG, W.-P.; Liu, D.; Liu, L.-J.; Sun, M.-Y.; Nawaz, T.; Wu, X.; Zhang, Y.; Li, Z.; Huang, Y.-L.; Yang, J.;* Yang, J.;* He, J.* Phosphinous Acid–Phosphinito Tetra-Icosahedral Au52 Nanocluster for Electrocatalytic Oxygen Reduction. JACS Au 2022, 2, 2617–2626. Wu, X.; Xiong, X.; Li, J.-L.; Luo, D.; Wu, K.; Wei, Y.-B.; Liu, X.-Y.; Lu, W.;* Li, D.; He, J.* An Adenine-Based Biological Metal-Organic Framework as an Efficient Luminescent Sensor for Tetracycline Detection. Eur. J. Inorg. Chem. 2022, e202200278. (VIP) Jin, J.-K.; Wu, K.; Liu, X.-Y.; Huang, G.-Q.; Huang, Y.-L.; Luo, D.; Xie, M.; Zhao, Y.; Lu, W.;* Zhou, X.-P.;* He, J.;* Li, D.* Building a Pyrazole–Benzothiadiazole–Pyrazole Photosensitizer into Metal–Organic Frameworks for Photocatalytic Aerobic Oxidation. J. Am. Chem. Soc. 2021, 143, 21340–21349. Wu, Q.-F.; Chen, G.; He, J.; Yu, J.-Q. Catalytic, Enantioselective, C–H Functionalization to Form Carbon–Carbon Bonds. Org. React. 2019, 100, 671−748. He, J.; Chen, C.; Fu, G. C.; Peters, J. C. Visible-Light-Induced, Copper-Catalyzed Three-Component Coupling of Alkyl Halides, Olefins, and Trifluoromethylthiolate to Generate Trifluoromethyl Thioethers. ACS Catal. 2018, 8, 11741–11748. Shao, Q.; Wu, Q.; He, J.; Yu, J.-Q. Enantioselective γ-C(sp3)–H Activation of Alkyl Amines via Pd(II)/Pd(0) Catalysis. J. Am. Chem. Soc. 2018, 140, 5322–5325. He, J.; Wasa, M.; Chan, K. S. L.; Shao, Q.; Yu, J.-Q. Palladium-Catalyzed Transformations of Alkyl C–H Bonds. Chem. Rev. 2017, 117, 8754–8786. Shao, Q.; He, J.; Wu, Q.; Yu, J.-Q. Ligand-Enabled γ-C(sp3)–H Cross-Coupling of Nosyl-Protected Amines with Aryl- and Alkylboron Reagents. ACS Catal. 2017, 7, 7777–7782. Wang, H.-W.; Lu, Y.; Zhang, B.; He, J.; Xu, H.-J.; Kang, Y.-S.; Sun, W.-Y.; Yu, J.-Q. Ligand-Promoted Rhodium(III)-Catalyzed ortho-C–H Amination of Benzamides with Free Amines. Angew. Chem. Int. Ed. 2017, 56, 7449–7453. Pei, Q.-L.; Che, G.-D.; Zhu, R.-Y.; He, J.; Yu, J.-Q. An Epoxide-Mediated Deprotection Method for Acidic Amide Auxiliary. Org. Lett. 2017, 19, 5860–5863. Zhu, R.-Y.; Saint-Denis, T. G.; Shao, Y.; He, J.; Sieber, J. D.; Senanayake, C. H.; Yu, J.-Q. Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)–H Bonds. J. Am. Chem. Soc. 2017, 139, 5724–5727. Hoyt, C. B.; Lee, L.-C.; He, J.; Yu, J.-Q.; Jones, C. W. Selective C(sp3)–H Monoarylation Catalyzed by a Covalently Cross-Linked Reverse Micelle-Supported Palladium Catalyst. Adv. Synth. Catal. 2017, 359, 3611–3617. He, J.; Shao, Q.; Wu, Q.; Yu, J.-Q. Pd(II)-Catalyzed Enantioselective C(sp3)–H Borylation. J. Am. Chem. Soc. 2017, 139, 3344–3347. Fu, H.; Shen, P.-X.; He, J.; Zhang, F.; Li, S.; Wang, P.; Liu, T.; Yu, J.-Q. Ligand-Enabled Alkynylation of C(sp3)–H Bonds with Pd(II) Catalysts. Angew. Chem. Int. Ed. 2017, 56, 1873–1876. Wu, Q.-F.; Shen, P.-X.; He, J.; Wang, X.-B.; Zhang, F.; Shao, Q.; Zhu, R.-Y.; Mapelli, C.; Qiao, J. X.; Poss, M. A.; Yu, J.-Q. Formation of α-Chiral Centers by Asymmetric β-C(sp3)–H Arylation, Alkenylation, and Alkynylation. Science 2017, 355, 499–503. Wang, P.; Li, G.-C.; Jain, P.; Farmer, M.; He, J.; Shen, P.-X.; Yu, J.-Q. Ligand-Promoted Meta-C–H Amination and Alkynylation. J. Am. Chem. Soc. 2016, 138, 14092–14099. Lee, L.-C.; He, J.; Yu, J.-Q.; Jones, C. W. Functionalized Polymer-Supported Pyridine Ligands for Palladium-Catalyzed C(sp3)–H Arylation. ACS Catal. 2016, 6, 5245–5250. Jiang, H.;† He, J.;† Liu, T.; Yu, J.-Q. Ligand-Enabled γ-C(sp3)–H Olefination of Amines: En Route to Pyrrolidines. J. Am. Chem. Soc. 2016, 138, 2055–2059. He, J.; Jiang, H.; Takise, R.; Zhu, R.-Y.; Chen, G.; Dai, H.-X.; Dhar, T. G. M.; Shi, J.; Zhang, H.; Cheng, P. T. W.; Yu, J.-Q. Ligand-Promoted Borylation of C(sp3)−H Bonds with Pd(II) Catalysts. Angew. Chem. Int. Ed. 2016, 55, 785–789. Zhu, R.-Y.; Tanaka, K.; Li, G.-C.; He, J.; Fu, H.-Y.; Li, S.-H.; Yu, J.-Q. Ligand-Enabled Stereoselective β-C(sp3)−H Fluorination: Synthesis of Unnatural Enantiopure anti-β-Fluoro-α-Amino Acids. J. Am. Chem. Soc. 2015, 137, 7067–7070. He, J.; Takise, R.; Fu, H.; Yu, J.-Q. Ligand-Enabled Cross-Coupling of C(sp3)–H Bonds with Arylsilanes. J. Am. Chem. Soc. 2015, 137, 4618–4621. He, J.; Shigenari, T.; Yu, J.-Q. Palladium(0)/PAr3-Catalyzed Intermolecular Amination of C(sp3)–H Bonds: Synthesis of β-Amino Acids. Angew. Chem. Int. Ed. 2015, 54, 6545–6549. Chen, G.; Shigenari, T.; Jain, P.; Zhang, Z.; Jin, Z.; He, J.; Li, S.; Mapelli, C.; Miller, M. M.; Poss, M. A.; Scola, P. M.; Yeung, K.-S.; Yu, J.-Q. Ligand-Enabled β-C–H Arylation of α-Amino Acids Using a Simple and Practical Auxiliary. J. Am. Chem. Soc. 2015, 137, 3338–3351. Zhu, D.; Yang, G.; He, J.; Chu, L.; Chen, G.; Gong, W.; Chen, K.; Eastgate, M.; Yu, J.-Q. Ligand-Promoted Ortho-C–H Amination with Pd Catalysts. Angew. Chem. Int. Ed. 2015, 54, 2497–2500. Zhu, R.-Y.; He, J.; Wang, X.-C.; Yu, J.-Q. Ligand-Promoted Alkylation of C(sp3)–H and C(sp2)–H Bonds. J. Am. Chem. Soc. 2014, 136, 13194–13197. Deng, Y.; Gong, W.; He, J.; Yu, J.-Q. Ligand-Enabled Triple C–H Activation Reactions: One-Pot Synthesis of Diverse 4-Aryl-2-Quinolinones from Propionamide. Angew. Chem. Int. Ed. 2014, 53, 6692–6695. He, J.; Li, S.; Deng, Y.; Fu, H.; Laforteza, B. N.; Spangler, J. E.; Homs, A.; Yu, J.-Q. Ligand-Controlled C(sp3)–H Arylation and Olefination in Synthesis of Unnatural Chiral α-Amino Acids. Science 2014, 343, 1216–1220. He, J.; Wasa, M.; Chan, K. S. L.; Yu, J.-Q. Palladium(0)-Catalyzed Alkynylation of C(sp3)–H Bonds. J. Am. Chem. Soc. 2013, 135, 3387–3390. Wasa, M.; Chan, K. S. L.; Zhang, X.-G.; He, J.; Miura, M.; Yu, J.-Q. Ligand-Enabled Methylene C(sp3)–H Bond Activation with a Pd(II) Catalyst. J. Am. Chem. Soc. 2012, 134, 18570–18572. He, J.; Lu, Z.; Chai, G.; Fu, C.; Ma, S. CuCl-Catalyzed Stereoselective Conjugate Addition of Grignard Regents to 2,3-Allenoates. Tetrahedron 2012, 68, 2719–2724.