Rice, Nancy - Western Kentucky University

个人简介

Post-doctoral Fellow University of Colorado B.S. in Recombinant Genetics, Western Kentucky University Ph.D. in Biochemistry, University of Tennessee Health Science Center

研究领域

Investigations in my laboratory focus on understanding the molecular mechanisms that lead to the high prevalence of essential hypertension (EH) in rural Kenya. We are currently testing the hypothesis that salt-sensitive EH is prevalent in Kasigau, Kenya as a result of polymorphic and/or epigenetic modifications of the renin-angiotensin gene system, the key hormonal pathway that regulates blood volume and pressure. To test this hypothesis, we are currently conducting a community-based participatory study that to assess six villages in Kasigau, Kenya with regard to the prevalence and current management of hypertension as well as the frequency of common environmental risk behaviors associated with it. Polymorphic variation in the ACE, AGT, AT1, and HSD11B2, genes known to be correlated with salt-sensitive hypertension, are also being examined from genomic DNA isolated from hypertensive participants. Lastly, global methylation patterns are being analyzed from hypertensive versus normotensive participants I order to correlate epigentic changes with salt-sensitive hypertension. These studies are aimed at providing key epidemiological and genetic information regarding mechanisms that will be directly translatable into prevention, treatment, and control of hypertension. Long-term, we hope to use our results to impact the development and implementation of cost-effective therapeutic interventions and that will have broad application for lowering the CNCD burden in Kenya and other developing countries.

近期论文

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Chavarria-Smith, J. §, Cooper, N.and Rice, N.A. A mutation in the coding region of Phka1 results in transcriptional repression of all phosphorylase kinase genes in the I/LnJ mouse. J. Cellular Biochemistry. In preparation. Sharma, B.V., Rowland, N.S., Faughn, J., Eastes, A. N., Walch, E.M. and Rice, N.A. (2014) Pulmonary proto-myofibroblast differentiation increases endothelial nitric oxide synthase expression and cell survival. J. of Cellular Biochemistry. In preparation Sharma, B.V., Rowland, N.S., Clouse, M.M., § and Rice, N.A. (2014) An improved bioassay for measuring low levels of nitric oxide in cultured pulmonary myofibroblasts. Advances in Biological Chemistry,4, 214-221. Mefford, A.M. , Ayers, C.C., Rowland, N.S. and Rice, NA. (2013) The phka1 deficient I/LnJ mouse exhibits endurance exercise deficiency with no compensatory changes in glycolytic gene expression. Open Journal of Molecular and Integrative Physiology, 3, 87-94. doi: 10.4236/ojmip.2013.32014 Kang, H. et al. (2012) Gender differences in student performance in large lecture classrooms using personal response systems (“clickers”) with case studies. Learning, Media and Technology 37:1, 53-76. (Large pedagogical work from NSF CCLI grant– listed as Associate Author due to journal limitation of author number) Wolter, B. et al (2011) Students’ perceptions of using personal response systems (“clickers”) with cases in science. J. College Science in Teaching. 40:4, 14-19. (Large pedagogical work from NSF CCLI grant– listed as Associate Author due to journal limitation of author number) Lundeberg, M.A., Kang, H., Wolter, B., delMas, R., Armstrong, N., Borsari, B., Boury, N., Brickman, P., Hannam, K., Heinz, C., Horvath, T., Knabb, M., Platt, T., Rice, N., Rogers, B., Sharp, J., Ribbens, E., Maier, K.S., Deschryver, M., Hagley, R., Goulet, T. , and Herreid, C.F. (2011) Context matters: increasing understanding with interactive clicker case studies. Education Tech Research Dev 59:645–671. Winchester, J. S., Rouchka, E.C., and Rice, N.A. (2007) In silico characterization of phosphorylase kinase: evidence for an alternate intronic polyadenylation site in PHKG1. Mol. Genet. Metab. 92: 234-242. Archila, S., King, M.A.§, Carlson, G.M. and Rice, N.A. (2006) The cytoskeletal organizing protein Cdc42- interacting protein 4 associates with phosphorylase kinase in skeletal muscle. Biochem. Biophys. Res. Comm. 345, 1592-1599. Rice, N.A. and Leinwand, L.A. (2003) Skeletal Myosin Heavy Chain Function in Cultured Lung Myofibroblasts J. Cell Biol. 163: 119-129.