Jacobshagen, Sigrid - Western Kentucky University

个人简介

Ph.D. 1988 Plant Biochemistry, Free University of Berlin, Germany M.S. 1985 Biology, Justus-Liebig-University of Giessen, Germany

研究领域

Research in my lab is concerned with the circadian clock. We are using the unicellular green alga Chlamydomonas as a model organism to study the circadian clock, because we can measure its daily rhythm of swimming towards light in an automated fashion. The rhythm is very similar to the daily sleep/wake cycle in humans. Projects in the lab center on the photoreceptor proteins that are able to reset the circadian clock using physiological, molecular, biochemical and cell biological techniques. We are also interested in understanding how the circadian clock regulates genes so that they show a circadian rhythm in their expression. A third interest is the use of mathematical equations to model the circadian clock.

近期论文

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Forbes-Stovall J., Howton J., Young M., Davis G., Chandler T., Kessler B., Rinehart C.A., and Jacobshagen S. (2014) Chlamydomonas reinhardtii strain CC-124 is highly sensitive to blue light in addition to green and red light in resetting its circadian clock, with the blue-light photoreceptor plant cryptochrome likely acting as negative modulator. Plant Physiology and Biochemistry 75, 14-23. Gaskill C., Forbes-Stovall J., Young M., Kessler B., Rinehart C.A., and Jacobshagen S. (2010) Improved automated monitoring and new analysis algorithm for circadian phototaxis rhythms in Chlamydomonas. Plant Physiology and Biochemistry 48, 239-246. Jacobshagen S., Kessler B., and Rinehart C.A. (2008) At least four distinct circadian regulatory mechanisms are required for all phases of rhythms in mRNA amount. Journal of Biological Rhythms 23, 511-524.