个人简介

Education B.S. in Chemistry, 1973, Texas A&M University Ph.D. in Chemistry, 1975, Texas A&M University NIH Postdoctoral Fellow 1977-79, University of Wisconsin

研究领域

Catalysis Chemical Biology and Biochemistry Organic Chemistry

Molecular and Biological Diversity Biological Catalysis Mining Genomes for Novel Chemicals and Catalysts Drug Targeting and Design Enzyme Folding and Dynamics Enzyme Engineering for Biofuel Biosynthesis and Pollutant Degradation Chemienzymatic Organic Synthesis

近期论文

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Oxaloacetate hydrolase: The C-C bond lyase of oxalate secreting fungi. Han Y, Joosten HJ, Niu W, Zhao Z, Mariano PS, McCalman MT, van Kan JA, Schaap PJ, Dunaway-Mariano D. (2007) J. Biol. Chem. 282 (13): 9581-9590. Rational Redesign of the 4-Chlorobenzoate Binding Site of 4-Chlorobenzoate: Coenzyme A Ligase for Expanded Substrate Range. Wu R, Reger AS, Cao J, Gulick AM, Dunaway-Mariano D. (2007) Biochemistry 46: 14487-14499. Swiveling Domain Mechanism in Pyruvate Phosphate Dikinase. Lim K, Read RJ, Chen CC, Tempczyk A, Wei M, Ye D, Wu C, Dunaway-Mariano D, Herzberg O. (2007) Biochemistry 46: 14845-14853. Identification of fungal oxaloacetate hydrolyase within the isocitrate lyase/PEP mutase enzyme superfamily using a sequence marker-based method. Joosten HJ, Han Y, Niu W, Vervoort J, Dunaway-Mariano D, Schaap PJ. (2008) Proteins. 70(1):157-166. The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function. Peisach E, Wang L, Burroughs AM, Aravind L, Dunaway-Mariano D, Allen KN. (2008) Proteins. 70(1): 197-207. Structure and Function of PA4872 from Pseudomonas aeruginosa, a Novel Class of Oxaloacetate Decarboxylase from the PEP Mutase/Isocitrate Lyase Superfamily. Narayanan BC, Niu W, Han Y, Zou J, Mariano PS, Dunaway-Mariano D, Herzberg O. (2008) Biochemistry 47: 167-182. Inactivation of Microbial Arginine Deiminases by l-Canavanine. Li L, Li Z, Chen D, Lu X, Feng X, Wright EC, Solberg NO, Dunaway-Mariano D, Mariano PS, Galkin A, Kulakova L, Herzberg O, Green-Church KB, Zhang L. (2008) J. Am. Chem. Soc., 130(6): 1918-1931. Divergence of function in the hot dog fold enzyme superfamily: the bacterial thioesterase YciA. Zhuang Z, Song F, Zhao H, Li L, Cao J, Eisenstein E, Herzberg O, Dunaway-Mariano D. (2008) Biochemistry 47: 2789-2796. Structure of YciA from Haemophilus influenzae (HI0827), a hexameric broad specificity acyl-coenzyme A thioesterase. Willis MA, Zhuang Z, Song F, Howard A, Dunaway-Mariano D, Herzberg O. (2008) Biochemistry 47: 2797-2805. The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state. Lu Z, Dunaway-Mariano D, Allen KN. (2008) PNAS 105: 5687-5692. The Electrostatic Driving Force for Nucleophilic Catalysis in l-Arginine Deiminase: A Combined Experimental and Theoretical Study. Li L, Li Z, Wang C, Xu D, Mariano PS, Guo H, Dunaway-Mariano D. (2008) Biochemistry 47: 4721-4732. Structural characterization of a 140 degrees domain movement in the two-step reaction catalyzed by 4-chlorobenzoate:CoA ligase. Reger AS, Wu R, Dunaway-Mariano D, Gulick AM. (2008) Biochemistry 47: 8016-8025. Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis. Wu R, Cao J, Lu X, Reger AS, Gulick AM, Dunaway-Mariano D. (2008) Biochemistry 47: 8026-8039. Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN). Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D. (2008) Chem Biol. 2008 Sep 22;15(9):893-7. Enzyme function discovery. Dunaway-Mariano D. Structure 2008 Nov 12;16(11):1599-600. Structure-function analysis of 2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphatase defines specificity elements in type C0 haloalkanoate dehalogenase family members. Lu Z, Wang L, Dunaway-Mariano D, Allen KN. J Biol Chem. 2009 Jan 9;284(2):1224-33. In vitro kinetic analysis of substrate specificity in enterobactin biosynthetic lower pathway enzymes provides insight into the biochemical function of the hot dog-fold thioesterase EntH. Chen D, Wu R, Bryan TL, Dunaway-Mariano D. Biochemistry. 2009 Jan 27;48(3):511-3. Structure and Function of 2,3-Dimethylmalate Lyase, a PEP Mutase/Isocitrate Lyase Superfamily Member. Narayanan B, Niu W, Joosten HJ, Li Z, Kuipers RK, Schaap PJ, Dunaway-Mariano D, Herzberg O. J Mol Biol. 2009 Feb 20;386(2):486-503. Analysis of the Structural Determinants Underlying Discrimination between Substrate and Solvent in -Phosphoglucomutase Catalysis. Allen K, Dunaway-Mariano D. Biochemistry. 2009 Jan 20. [Epub ahead of print] The Mechanisms of Human Hotdog-fold Thioesterase 2 (hTHEM2) Substrate Recognition and Catalysis Illuminated by a Structure and Function Based Analysis. Cao J, Xu H, Zhao H, Gong W, Dunaway-Mariano D. Biochemistry. 2009 Jan 26. [Epub ahead of print]