Harries, Phillip A - Pittsburg State Universit

个人简介

Dr. Harries was honored with the 2015 Robert K. Ratzlaff Outstanding Faculty Award by the Student Government Association from student nominees of faculty that demonstrate excellence in instruction and service to students on campus. Read about the 2015 Recipients and the Faculty Award.

研究领域

Virus infections pose a serious health threat to both plants and animals. In order for such infections to exert their negative effects, however, viruses must be able to move from cell-to-cell and spread within their hosts. My research examines the methods by which viruses hijack plant cells to facilitate their movement. In particular, I am interested in the potential role of the host cell cytoskeleton in this process. The cytoskeleton can serve as tracks along which cellular cargo, including invading viruses, can travel. Tomato bushy stunt virus (TBSV) has been shown to require the host cytoskeleton for its cell-to-cell spread but the mechanism underlying this requirement is unknown. I am currently studying the potential association of TBSV proteins with various components of the plant cell cytoskeleton using both microscopy and biochemical techniques. A greater understanding of the mechanisms of virus movement may lead to methods for slowing or stopping virus spread in important crop plants.

近期论文

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Schoelz, J.E., Harries, P.A., Nelson, R.S. (2011) Intracellular Transport of Plant Viruses: Finding the Door out of the Cell. Molecular Plant,4(5):813-31 Harries, P.A., Ding, B. (2011) Cellular factors in plant virus movement: At the leading edge of macromolecular trafficking in plants. Virology 411, 237-243 (Co-corresponding author on this paper) Harries, P.A.,Schoelz, J.E., Nelson, R.S. (2010) Intracellular Transport of Viruses and Their Components: Utilizing the Cytoskeleton and Membrane Highways. Molecular Plant-Microbe Interactions 23, 1381-1393 (one of most downloaded articles for this journal) Harries, P.A.,Park, J.-W., Sasaki, N., Ballard, K.D., Maule, A.J., Nelson, R.S. (2009) Differing requirements for actin and myosin by plant viruses for intercellular movement. Proc. Nat. Acad. Sci. 13;106:17594-9 Harries, P.A.,Schoelz, J.E., Nelson, R.S. (2009) Covering common ground: F-actin dependent transport of plant viral protein inclusions reveals a novel mechanism for movement utilized by unrelated viral proteins. Plant Signal Behav. 2009 May;4(5):454-6 Harries, P.A., Palanichelvam, K., Yu, W., Schoelz, J.E., Nelson, R.S. (2009) The Cauliflower mosaic virus protein P6 forms motile inclusions that traffic along actin microfilaments and stabilize microtubules. Plant Physiology 149, 1005-1016 Harries, P.A., Nelson, R.S. (2008) Movement of Viruses in Plants. Encyclopedia of Virology, 3rd Edition. pp. 348-355. Elsevier Press Harries, P.A., Karuppaiah, P., Bhat, S., Nelson, R.S. (2008) Tobacco mosaic virus 126-kDa protein increases the susceptibility of Nicotiana tabacum to other viruses and its dosage affects virus-induced gene silencing. Molecular Plant-Microbe Interactions 21, 1539-1548 Harries, P.A., Pan, A., Quatrano, R.S. (2005) Actin-related protein 2/3 complex component ARPC1 is required for proper cell morphogenesis and polarized cell growth in Physcomitrella patens. Plant Cell 17, 2327-2339 Cove, D.J., Bezanilla, M.B., Harries, P.A., Quatrano, R.S. (2005) Mosses as model systems for the study of metabolism and development. Annual Review of Plant Biology 57, 497-520