Wright, Sterling N - Murray State University

个人简介

BS, Texas Tech University; MS, Texas Tech University; PhD, University of Texas at Austin. The research in our laboratory examines the pharmacology and biophysics of voltage-dependent sodium channels. We investigate the influence of local anesthetic agents and naturally occurring neurotoxins on the gating kinetics of the channels.

研究领域

The research in my laboratory involves the investigation of ion channel pharmacology and biophysics. Voltage-dependent sodium channels, which are responsible for generating action potentials in muscle (cardiac and skeletal muscle) and neurons, are susceptible to block or modification by numerous naturally occurring neurotoxins and synthetic agents. My research has focused on the modification of sodium channel kinetics by Site 2 neurotoxins such as aconitine, lappaconitine, and batrachotoxin, as well as the block of sodium channels by a variety of local anesthetics and aminoglycosides.

近期论文

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*Godwin, S.A. Cox, J.R. and Wright, S.N. (2005) Modeling of benzocaine analog interactions with the D4S6 segment of NaV4.1 voltage-gated sodium channels. Biophysical Chemistry 113:1-7 *graduate student author *Yeiser, A.J., Cox, J.R. and Wright, S.N. (2004) Voltage-dependent inhibition of rat skeletal muscle sodium channels by aminoglycoside antibiotics Pflügers Archiv, European Journal of Physiology 448:204-213 *undergraduate student author Wright, S.N. (2003) Cardiotoxic and antiarrhythmic tertiary amine local anesthetics: sodium channel affinity vs. sodium channel gating. Current Vascular Pharmacology 1:239-242 Wright, S.N. (2002) Comparison of aconitine-modified human heart (hH1) and rat skeletal (m1) muscle Na+channels: an important role for external Na+ ions. Journal of Physiology (London) 583:759-771 Wright, S.N. (2001) Irreversible block of human heart (hH1) sodium channels by the plant alkaloid, lappaconitine. Molecular Pharmacology 59:183-192