Nakamura, Suguru - Murray State University

研究领域

Dr. Nakamura’s research is focused on the physiological studies of acid-base balance and ion transports in the kidney. His studies include the characterization of the signal transduction pathway involved in stimulation of a potassium-dependent acid secretion transporter (H+-K+-ATPase) and a potassium-independent acid secretion transporter (H+-ATPase) in response to changes in many animal models, such as diabetes and hypertension. Recently, his laboratory demonstrated an essential link between these acid secretion transporters and the glycolysis metabolic pathway. This link may be crucial in understanding the pathophysiological mechanism of diabetes and the metabolism of cancer cells, and the ability of cells to survive during an interruption in blood flow. The majority of his laboratory research utilizes in vitro microperfusion of isolated single kidney tubule in animal models that include transgenic mice. Advanced techniques used in Dr. Nakamura’s laboratory include fluorescent ratio imaging, imaging analysis, cell membrane potential, and bicarbonate or ammonia flux measurements. Undergraduate and graduate students working in this laboratory will have an opportunity to apply many advanced methods in physiology, biochemistry, and recombinant DNA to understanding cellular regulation and molecular cell biology.

近期论文

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1 Tyler Downing, Amy Mangla, Michael Banta, Suguru Nakamura. Enzymatic Activity of Renal H-K-ATPase in the Outer Medullary Collecting Duct of Transgenic Mice. International Journal of Clinical Medicine. Vol.5 No.20: 1239-1247, 2014. 2 Guojun, Wei, J. Ravellette, S. Nakamura. Potassium Depletion Stimulates Beta Subunit of Colonic H+-K+-ATPase in Mice. International Journal of Clinical Medicine Vol.4 No.5: 244-250, 2013. 3 Guojun Wei, Sakura Higashi and Suguru Nakamura. Gastric H+/K+ATPase beta subunit in the colonic H+/K+ATPase knockout mice. FASEB J. (Federation of American Societies for Experimental Biology Journal) April, 24, 607.2, 2010. 4 Xu, J, P. Song, S. Nakamura, M. Miller, S. Barone, SL. Alper, B. Riederer, J. Bonhagen, LJ. Arend, H. Amlal, U. Seidler, M. Soleimani. Deletion of the chloride transporter Slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. Journal of Biological Chemistry 284(43):29470-29479, 2009. 5 Zac Elmore, Christopher Muncie, Sakura Higashi, Guojun Wei, Xuelian Chen, and Suguru Nakamura. Immnoprecipitation of Gastric H+/K+ATPase Beta Subunit in Hyperglycemic Mice. FASEB J. (Federation of American Societies for Experimental Biology Journal) April, 23, 798.4, 2009. 6 Amy Mangla, D. Crabtree, T. Downing, V. Ingland, and S. Nakamura. Enzymatic activity of renal H-K-ATPase in the OMCD of transgenic mice. Journal of Experimental Biology: 116, 2006. 7 Nakamura, Suguru. H+-ATPase activity in selective disruption of H+-K+-ATPase alpha 1 gene of mice under normal and K-depleted conditions. Journal of Laboratory and Clinical Medicine 147: 45-51, 2006. 8 Chen Wan Chun and S. Nakamura. Determining Enzymatic Activity of H+-K+-ATPase in Renal Outer Medullary Collecting Duct (OMCD). Chrysalis, MSU Undergraduate Research Journal. Vol. 2: 6-10, 2006. 9 Nakamura, Suguru. Glucose activates H(+)-ATPase in kidney epithelial cells. American Journal of Physiology 287 (Cell Physiology): C97-105, 2004. 10 Zhou, Xiaoming, S. Nakamura, SL. Xia, and CS. Wingo. Increased CO2 stimulates K/Rb reabsorption mediated by H-K-ATPase in CCD of potassium-restricted rabbit. Am. J. Physiol. 281 (Renal Physiol.): F366-373, 2001. 11 Nakamura, Suguru, H. Amlal, M. Soleimani, and J. Galla. Pathways for HCO3- reabsorption in mouse medullary collecting duct segments. J Lab Clin Med. 136: 218-23, 2000. 12 Nakamura, Suguru, H. Amlal, J. Galla, and M. Soleimani. NH4+ secretion in inner medullary collecting duct in potassium deprivation: Role of colonic H+-K+-ATPase. Kidney Int. 56: 2160-2167, 1999. 13 Nakamura, Suguru, H. Amlal, PJ Schultheis, J. Galla, GE Shull and M. Soleimani. HCO3-reabsorption in renal collecting duct of NHE-3 deficient mouse: a compensatory response. Am. J. Physiol. 276 (Renal Physiol. 6): F914-921, 1999. 14 Nakamura, Suguru, H. Amlal, J. Galla, and M. Soleimani. Colonic H+ -K+ -ATPase is induced and mediates increased HCO3- reabsorption in inner medullary collecting duct in potassium depletion. Kidney Int. 54: 1233-1239, 1998. 15 Nakamura, Suguru, Z. Wang, J. Galla, and M. Soleimani. K+ depletion increases HCO3-reabsorption in OMCD by activation of colonic H+ -K+ -ATPase. Am. J. Physiol. 274 (Renal Physiol. 43): F687-692, 1998.