Ghadiri, M.Reza - The Scripps Research Institute

研究领域

Organic, Bioorganic, and Materials Chemistry Our group is involved in a multidisciplinary research effort that uses disciplines ranging from synthetic organic and inorganic chemistry to materials science and recombinant DNA technology to develop novel methods for the rational design and construction of functional biomaterial-based structures. Our goal is to provide novel applications in the field of molecular and system engineering as well as advance our fundamental understanding of living chemical processes. Currently, research projects in our laboratory deal with various aspects of peptide and protein architecture and folding, design of synthetic receptors and enzymes, fabrication of novel biosensor arrays, self-replicating molecular systems, and self-organized nonlinear autocatalytic chemical networks and ecosystems. selected references

近期论文

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Zhao, Y., Black, A. S., Bonnet, D. J., Maryanoff, B. E., Curtiss, L. K., Leman, L. J., and Ghadiri, M. R. "In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I." J. Lipid Res. 2014, 55, 2053-2063. Leman, L. J., Maryanoff, B. E., and Ghadiri, M. R. "Molecules That Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis." J. Med. Chem. 2014, 57, 2169-2196. Zhao, Y., Imura, T., Leman, L. J., Curtiss, L. K., Maryanoff, B. E., and Ghadiri, M. R. "Mimicry of High-Density Lipoprotein: Functional Peptide-Lipid Nanoparticles Based on Multivalent Peptide Constructs." J. Am. Chem. Soc. 2013, 135, 13414-13424. Montenegro, J., Ghadiri, M. R., and Granja, J. R. "Ion Channel Models Based on Self-Assembling Cyclic Peptide Nanotubes." Acc. Chem. Res. 2013, 46, 2955-2965. Vickers, C. J., Olsen, C. A., Leman, L. J., and Ghadiri, M. R. "Discovery of HDAC inhibitors that lack an active site Zn2+-binding functional group." ACS Med. Chem. Lett. 2012, 3, 505-508. Olsen, C. A., Montero, A., Leman, L. J., and Ghadiri, M. R. "Macrocyclic peptoid-peptide hybrids as inhibitors of class I histone deacetylases." ACS Med. Chem. Lett. 2012, 3, 749-753. Montero, A., Gastaminza, P., Law, M., Cheng, G., Chisari, F. V., and Ghadiri, M. R. "Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus." Chem. Biol. 2011, 18, 1453-1462. Hutt, D. M., Olsen, C. A., Vickers, C. J., Herman, D., Chalfant, M. A., Montero, A., Leman, L. J., Burkle, R., Maryanoff, B. E., Balch, W. E., et al. "Potential agents for treating cystic fibrosis: Cyclic tetrapeptides that restore trafficking and activity of ΔF508-CFTR." ACS Med. Chem. Lett. 2011, 2, 703-707. Chu, J., Gonzalez-Lopez, M., Cockroft, S., Amorin, M., Ghadiri, M. R. "Real-Time Monitoring of DNA Polymerase Function and Stepwise Single-Nucleotide DNA Strand Translocation through a Protein Nanopore." Angew. Chem., Int. Ed. 2010, 49, 10106-10109. Olsen, C. A., and Ghadiri, M. R. "Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha-3-beta-tetrapeptides." J. Med. Chem. 2009, 52, 7836-7846. Ura, Y., Al-Sayah, M., Montenegro, J., Beierle, J. M., Leman, L. J., and Ghadiri, M. R. "Dynamic polythioesters via ring-opening polymerization of 1,4-thiazine-2,5-diones." Org. Biomol. Chem. 2009, 7, 2878-2884. Ura, Y., Beierle, J. M., Leman, L. J., Orgel, L. E., and Ghadiri, M. R. "Self-assembling sequence-adaptive peptide nucleic acids." Science 2009, 325, 73-77. Motiei, L., Rahimipour, S., Thayer, D. A., Wong, C.-H., and Ghadiri, M. R. "Antibacterial cyclic DL-alpha-glycopeptides." Chem. Commun. 2009, 3693-3695. Horne, W. S., Olsen, C. A., Beierle, J. M., Montero, A., and Ghadiri, M. R. "Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides." Angew. Chem., Int. Ed. 2009, 48, 4718-4724. Beierle, J. M., Horne, W. S., van Maarseveen, J. H., Waser, B., Reubi, J. C., and Ghadiri, M. R. "Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues." Angew. Chem., Int. Ed. 2009, 48, 4725-4729. Picuri, J. M., Frezza, B. M., and Ghadiri, M. R. "Universal translators for nucleic acid diagnosis." J. Am. Chem. Soc. 2009, 131, 9368-9377. Montero, A., Beierle, J. M., Olsen, C. A., and Ghadiri, M. R. "Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures." J. Am. Chem. Soc. 2009, 131, 3033-3041. Voelcker, N. H., Alfonso, I., and Ghadiri, M. R. "Catalyzed oxidative corrosion of porous silicon used as an optical transducer for ligand-receptor interactions." ChemBioChem 2008, 9, 1776-1786. Voelcker, N. H., Guckian, K. M., Saghatelian, A., and Ghadiri, M. R. "Sequence-addressable DNA logic." Small 2008, 4, 427-431. Cheng, G., Montero, A., Gastaminza, P., Whitten-Bauer, C., Wieland, S. F., Isogawa, M., Fredericksen, B., Selvarajah, S., Gallay, P. A., Ghadiri, M. R., and Chisari, F. V. "A virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro." Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 3088-3093.